BR112012006172A2 - derivados de alqueno oxindol e seus usos para o tratamento de obesidade, diabetes e hiperlipidemia - Google Patents
derivados de alqueno oxindol e seus usos para o tratamento de obesidade, diabetes e hiperlipidemiaInfo
- Publication number
- BR112012006172A2 BR112012006172A2 BR112012006172A BR112012006172A BR112012006172A2 BR 112012006172 A2 BR112012006172 A2 BR 112012006172A2 BR 112012006172 A BR112012006172 A BR 112012006172A BR 112012006172 A BR112012006172 A BR 112012006172A BR 112012006172 A2 BR112012006172 A2 BR 112012006172A2
- Authority
- BR
- Brazil
- Prior art keywords
- hyperlipidemia
- obesity
- diabetes
- treatment
- oxindole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2009/074060 WO2011032320A1 (en) | 2009-09-21 | 2009-09-21 | Novel alkene oxindole derivatives |
| PCT/EP2010/063770 WO2011033099A1 (en) | 2009-09-21 | 2010-09-20 | Alkene oxindole derivatives and their uses to treat obesity, diabetes and hyperlipidemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012006172A2 true BR112012006172A2 (pt) | 2016-05-31 |
Family
ID=43414813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012006172A BR112012006172A2 (pt) | 2009-09-21 | 2010-09-20 | derivados de alqueno oxindol e seus usos para o tratamento de obesidade, diabetes e hiperlipidemia |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20110071195A1 (2) |
| EP (1) | EP2480530A1 (2) |
| JP (1) | JP2013505281A (2) |
| KR (1) | KR20120068876A (2) |
| AU (1) | AU2010297252A1 (2) |
| BR (1) | BR112012006172A2 (2) |
| CA (1) | CA2772674A1 (2) |
| IN (1) | IN2012DN00765A (2) |
| MX (1) | MX2012002477A (2) |
| WO (2) | WO2011032320A1 (2) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011032320A1 (en) * | 2009-09-21 | 2011-03-24 | F. Hoffmann-La Roche Ag | Novel alkene oxindole derivatives |
| WO2013119774A1 (en) * | 2012-02-10 | 2013-08-15 | Virginia Commonwealth University | 3-(2-amino-ethyl)-alkylidene)-thiazolidine-2,4-dione and 1-(2-amino-ethyl)-alkylidene-1,3-dihydro-indol-2-one derivatives as selective sphingosine kinase 2 inhibitors |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| EP2769974A1 (en) * | 2013-02-21 | 2014-08-27 | Debiopharm S.A. | Novel AMPK activator |
| EP2970177A1 (en) | 2013-03-15 | 2016-01-20 | Pfizer Inc. | Indole compounds that activate ampk |
| US20160368870A1 (en) * | 2013-06-20 | 2016-12-22 | Boehringer Ingelheim International Gmbh | Olefin substituted oxindoles having ampk activity |
| EP2886541A1 (en) * | 2013-12-19 | 2015-06-24 | Sanofi | Oxindole derivatives, preparation thereof and therapeutic use in the treatment of AMPK-related diseases |
| ES2567105B1 (es) * | 2014-09-19 | 2017-02-10 | Consejo Superior De Investigaciones Científicas (Csic) | Derivados de indol para la prevención y/o tratamiento de diabetes ytrastornos metabólicos relacionados |
| CN106619616A (zh) * | 2015-11-04 | 2017-05-10 | 中国科学院上海药物研究所 | 3-烯基吲哚酮类衍生物在制备治疗miri药物中的用途及其药物组合物 |
| CN116323608A (zh) | 2020-05-19 | 2023-06-23 | 卡尔优普公司 | Ampk活化剂 |
| EP4172162A4 (en) | 2020-06-26 | 2024-08-07 | Kallyope, Inc. | AMPK ACTIVATORS |
| US12404348B2 (en) | 2021-11-19 | 2025-09-02 | The Brigham And Women's Hospital, Inc. | Bifunctional chimeric molecules for labeling of kinases with target binding moieties and methods of use thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP9800757A3 (en) * | 1996-01-17 | 1998-08-28 | Taiho Pharmaceutical Co Ltd | Intimal thickening inhibitors containing oxyindole derivatives and pharmaceutical compositions containing them |
| CA2289102A1 (en) * | 1997-05-07 | 1998-11-12 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| DE19816624A1 (de) * | 1998-04-15 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| US7825155B2 (en) * | 2005-09-14 | 2010-11-02 | Dainippon Sumitomo Pharma Co., Ltd. | Oxindole derivative as feeding control agent |
| WO2008033562A2 (en) * | 2006-09-15 | 2008-03-20 | Xcovery, Inc. | Kinase inhibitor compounds |
| ES2553340T3 (es) * | 2007-12-12 | 2015-12-07 | Rigel Pharmaceuticals, Inc. | Compuestos de carboxamida, sulfonamida y amina para trastornos metabólicos |
| KR20100115789A (ko) * | 2008-02-04 | 2010-10-28 | 머큐리 테라퓨틱스, 인코포레이티드 | Ａｍｐｋ 조절자 |
| JP5557845B2 (ja) * | 2008-10-31 | 2014-07-23 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体 |
| WO2011032320A1 (en) * | 2009-09-21 | 2011-03-24 | F. Hoffmann-La Roche Ag | Novel alkene oxindole derivatives |
-
2009
- 2009-09-21 WO PCT/CN2009/074060 patent/WO2011032320A1/en not_active Ceased
-
2010
- 2010-09-14 US US12/881,211 patent/US20110071195A1/en not_active Abandoned
- 2010-09-20 IN IN765DEN2012 patent/IN2012DN00765A/en unknown
- 2010-09-20 KR KR1020127007221A patent/KR20120068876A/ko not_active Withdrawn
- 2010-09-20 MX MX2012002477A patent/MX2012002477A/es not_active Application Discontinuation
- 2010-09-20 EP EP10757407A patent/EP2480530A1/en not_active Withdrawn
- 2010-09-20 WO PCT/EP2010/063770 patent/WO2011033099A1/en not_active Ceased
- 2010-09-20 JP JP2012530228A patent/JP2013505281A/ja not_active Ceased
- 2010-09-20 AU AU2010297252A patent/AU2010297252A1/en not_active Abandoned
- 2010-09-20 CA CA2772674A patent/CA2772674A1/en not_active Abandoned
- 2010-09-20 BR BR112012006172A patent/BR112012006172A2/pt not_active IP Right Cessation
-
2013
- 2013-01-18 US US13/744,480 patent/US8778973B2/en not_active Expired - Fee Related
-
2014
- 2014-06-03 US US14/294,213 patent/US20140288127A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2480530A1 (en) | 2012-08-01 |
| JP2013505281A (ja) | 2013-02-14 |
| MX2012002477A (es) | 2012-03-26 |
| US20130131114A1 (en) | 2013-05-23 |
| WO2011033099A1 (en) | 2011-03-24 |
| IN2012DN00765A (2) | 2015-06-26 |
| US20140288127A1 (en) | 2014-09-25 |
| WO2011032320A1 (en) | 2011-03-24 |
| CA2772674A1 (en) | 2011-03-24 |
| US20110071195A1 (en) | 2011-03-24 |
| KR20120068876A (ko) | 2012-06-27 |
| AU2010297252A1 (en) | 2012-02-02 |
| US8778973B2 (en) | 2014-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2383 DE 06-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |