BR112012008332A2 - processo para preparação de cinacalcet - Google Patents

processo para preparação de cinacalcet

Info

Publication number
BR112012008332A2
BR112012008332A2 BR112012008332A BR112012008332A BR112012008332A2 BR 112012008332 A2 BR112012008332 A2 BR 112012008332A2 BR 112012008332 A BR112012008332 A BR 112012008332A BR 112012008332 A BR112012008332 A BR 112012008332A BR 112012008332 A2 BR112012008332 A2 BR 112012008332A2
Authority
BR
Brazil
Prior art keywords
preparation
cinacalcet
formula
hydridate
conacalcet
Prior art date
Application number
BR112012008332A
Other languages
English (en)
Other versions
BR112012008332B1 (pt
BR112012008332A8 (pt
BR112012008332B8 (pt
Inventor
Giorgio Soriato
Johnny Foletto
Livius Cotarca
Massimiliano Forcato
Massimo Verzini
Nicola Catozzi
Roberto Giovanetti
Original Assignee
Zach System Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zach System Spa filed Critical Zach System Spa
Publication of BR112012008332A2 publication Critical patent/BR112012008332A2/pt
Publication of BR112012008332A8 publication Critical patent/BR112012008332A8/pt
Publication of BR112012008332B1 publication Critical patent/BR112012008332B1/pt
Publication of BR112012008332B8 publication Critical patent/BR112012008332B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/74—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

processo para preparação de cinacalcet. um processo para a preparação de n- [ (1r) -1-(1-naftil)etil] -3-(trifluorometil)-fenil]propan-1-amina de fórmula de sal cloridato de fórmula (i), isto é conacalcet.hcl e seu intermediário de fórmula (ix).
BR112012008332A 2009-09-10 2010-09-08 intermediário de cinacalcet, seu processo de preparação e processo para preparação de cinacalcet BR112012008332B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09169934.8 2009-09-10
EP09169934 2009-09-10
PCT/EP2010/063154 WO2011029833A1 (en) 2009-09-10 2010-09-08 Process for preparing cinacalcet

Publications (4)

Publication Number Publication Date
BR112012008332A2 true BR112012008332A2 (pt) 2016-03-22
BR112012008332A8 BR112012008332A8 (pt) 2017-07-11
BR112012008332B1 BR112012008332B1 (pt) 2021-02-23
BR112012008332B8 BR112012008332B8 (pt) 2021-05-25

Family

ID=42790570

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012008332A BR112012008332B8 (pt) 2009-09-10 2010-09-08 intermediário de cinacalcet, seu processo de preparação e processo para preparação de cinacalcet

Country Status (10)

Country Link
US (1) US8637708B2 (pt)
EP (1) EP2475641B1 (pt)
JP (1) JP5685594B2 (pt)
CN (1) CN102548955B (pt)
AU (1) AU2010294283B2 (pt)
BR (1) BR112012008332B8 (pt)
CA (1) CA2769659C (pt)
ES (1) ES2445532T3 (pt)
IL (1) IL217802A0 (pt)
WO (1) WO2011029833A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010215520B2 (en) * 2009-02-19 2016-07-21 F.I.S. - Fabbrica Italiana Sintetici S.P.A. Process for preparing Cinacalcet hydrochloride
CN106831441B (zh) * 2017-01-23 2019-04-02 江苏康思尔医药科技有限公司 一种盐酸西那卡塞的制备方法
CN108047056A (zh) * 2017-12-29 2018-05-18 山东泰和水处理科技股份有限公司 一种双(2-氯乙基)胺盐酸盐的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011068A (en) 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5504253A (en) 1994-07-15 1996-04-02 Nps Pharmaceuticals, Inc. Amine preparation
ES2285707T3 (es) 1994-10-21 2007-11-16 Nps Pharmaceuticals, Inc. Compuestos activos frente al receptor de calcio.
EP1881954B1 (en) 2005-05-16 2009-09-16 Teva Pharmaceutical Industries Ltd. Process for preparing cinacalcet hydrochloride
JP4638491B2 (ja) 2005-05-23 2011-02-23 テバ ファーマシューティカル インダストリーズ リミティド シナカルセト塩酸塩結晶フォームｉの調製方法
KR20080011320A (ko) 2006-04-27 2008-02-01 테바 파마슈티컬 인더스트리즈 리미티드 시나칼셋 염기의 제조 방법
US7449603B2 (en) 2006-04-27 2008-11-11 Teva Pharmaceutical Industries Ltd. Process for the preparation of cinacalcet base
AR061310A1 (es) 2006-06-08 2008-08-20 Medichem Sa Procesos para preparar compuestos intermediarios utiles para la preparacion de cinacalcet
EP1990333A1 (en) 2007-05-11 2008-11-12 Sandoz AG Process for the preparation of cinacalcet hydrochloride
EP2170805B1 (en) 2007-06-21 2016-03-16 Amgen Inc. Methods of synthesizing cinacalcet and salts thereof
ITMI20071261A1 (it) 2007-06-22 2008-12-23 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet
US20090093652A1 (en) 2007-08-16 2009-04-09 Michal Rafilovich Crystalline forms cinacalcet fumarate and cinacalcet succinate and processes for preparation thereof
AR070754A1 (es) 2007-09-18 2010-05-05 Medichem Sa Proceso mejorado para preparar clorhidrato de cinacalcet
SI2358659T1 (sl) 2008-10-28 2013-04-30 Zach System S.P.A. Postopek za pripravo cinakalceta
AU2010215520B2 (en) 2009-02-19 2016-07-21 F.I.S. - Fabbrica Italiana Sintetici S.P.A. Process for preparing Cinacalcet hydrochloride

Also Published As

Publication number Publication date
AU2010294283A1 (en) 2012-02-23
AU2010294283B2 (en) 2016-09-29
BR112012008332B1 (pt) 2021-02-23
JP2013504535A (ja) 2013-02-07
CA2769659A1 (en) 2011-03-17
EP2475641A1 (en) 2012-07-18
US8637708B2 (en) 2014-01-28
WO2011029833A1 (en) 2011-03-17
CN102548955A (zh) 2012-07-04
ES2445532T3 (es) 2014-03-03
IL217802A0 (en) 2012-03-29
BR112012008332A8 (pt) 2017-07-11
CN102548955B (zh) 2014-06-04
JP5685594B2 (ja) 2015-03-18
EP2475641B1 (en) 2013-11-06
US20120238778A1 (en) 2012-09-20
CA2769659C (en) 2017-10-24
BR112012008332B8 (pt) 2021-05-25

Similar Documents

Publication Publication Date Title
BR112013023471A2 (pt) cocristal de n-[2-(7-metóxi-1-naftil) etil]acetamina, e, processo para preparar um cocristal.
BRPI0714558B8 (pt) processo para a preparação de (1r,2r)-3-(3-dimetilamino-1-etil-2-metil-propil)-fenol
UY33317A (es) Nuevos derivados de pirazol
EA201300388A1 (ru) Соединения замещенного бензамида
BRPI1006162A2 (pt) "composto,processo para preparar um composto,formulação farmacêutica,e uso de um composto".
JO3297B1 (ar) تركيبات و طرق لتعديل fxr
BR112013009486A2 (pt) processo para preparação de formas de dosagem gastrirretentivas multiparticuladas
JO3213B1 (ar) بلورات مشتركة جديدة من أجوميلاتين
BR112014000319A2 (pt) uso de compostos da fórmula i, método de combate a fungos fitopatogênicos, semente revestida, processo de preparação de compostos da fórmula i, compostos da fórmula xi e composição agroquímica
MX2012007759A (es) Compuestos intermedios y procesos para la preparacion de tapentadol y compuestos relacionados.
WO2012056458A3 (en) Intermediate compounds and process for the preparation of fingolimod
BR112013008008A2 (pt) composto, composição farmacêutica e processo para preparar um composto
CL2012002082A1 (es) Proceso para la preparacion de lacosamida, por hidroximetilación; compuestos intermediarios.
CL2011001405A1 (es) Procedimiento para la preparacion de n-[2-(7-metoxi-1-naftil)etil]acetamida, agometalina.
WO2013093931A3 (en) Novel prodrugs of phenolic drugs
CY1123700T1 (el) Παιδιατρικη φαρμακοτεχνικη μορφη
BRPI0919635A8 (pt) Processo para preparação de cinacalcet
WO2010094674A3 (en) Process for preparing cinacalcet hydrochloride
BRPI0820289A2 (pt) Processo para preparar ácido cianídrico, e, uso de um microevaporador.
WO2012176218A8 (en) Process for preparing rosuvastatin calcium through novel amine salt
EA201170481A1 (ru) Сокристаллы
BR112012008332A2 (pt) processo para preparação de cinacalcet
BRPI0918990A2 (pt) composto, combinação de composto ativo, semente, processo para combater fungos fitopatogênicos, medicamento, e, processo para prepara um antimicótico.
BR112014009437A2 (pt) processo para preparar um composto, composto e uso de um composto
BR112014004437A2 (pt) composto, uso de um composto, composição farmacêutica, preparação farmacêutica, processo para preparação de um composto, e intermediário.

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT)

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/02/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/09/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF