BR112014001908A2 - derivados aza heterocíclicos substituídos - Google Patents

derivados aza heterocíclicos substituídos

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Publication number
BR112014001908A2
BR112014001908A2 BR112014001908A BR112014001908A BR112014001908A2 BR 112014001908 A2 BR112014001908 A2 BR 112014001908A2 BR 112014001908 A BR112014001908 A BR 112014001908A BR 112014001908 A BR112014001908 A BR 112014001908A BR 112014001908 A2 BR112014001908 A2 BR 112014001908A2
Authority
BR
Brazil
Prior art keywords
substituted heterocyclic
aza derivatives
derivatives
compounds
aza
Prior art date
Application number
BR112014001908A
Other languages
English (en)
Inventor
Lesch Bernhard
Lee Jeewoo
Frank-Foltyn Robert
Christoph Thomas
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of BR112014001908A2 publication Critical patent/BR112014001908A2/pt

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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Abstract

resumo patente de invenção: "derivados aza heterocíclicos substituídos". a presente invenção refere-se a derivados aza heterocíclicos como ligantes de receptor vaniloide, a composições farmacêuticas contendo esses compostos e também a esses compostos para uso no tratamento e/ou profilaxia de dor e doenças e/ou distúrbios relacionados.
BR112014001908A 2011-07-26 2012-07-25 derivados aza heterocíclicos substituídos BR112014001908A2 (pt)

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EP11006115 2011-07-26
PCT/EP2012/003138 WO2013013817A1 (en) 2011-07-26 2012-07-25 Substituted heterocyclic aza derivatives

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AR (1) AR087302A1 (pt)
AU (1) AU2012289255A1 (pt)
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ES2713700T3 (es) 2014-11-24 2019-05-23 Medifron Dbt Inc Derivados de carboxamida y urea a base de oxazol y tiazol sustituidos como ligandos del receptor de vainilloide II
HUE057041T2 (hu) 2015-07-06 2022-04-28 Alkermes Inc Hiszton deacetiláz hetero-halogén gátlói
WO2017007755A1 (en) 2015-07-06 2017-01-12 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
EP3130590A1 (en) 2015-08-13 2017-02-15 Grünenthal GmbH Aromatic aza compounds as vr1/trpv1 ligands
EP3130589A1 (en) 2015-08-13 2017-02-15 Grünenthal GmbH Heterocyclic aza compounds
US10604487B2 (en) 2016-01-14 2020-03-31 Research Cooperation Foundation Of Yeungnam University Pyridinol derivative or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing same as active ingredient
HRP20220223T1 (hr) 2017-01-11 2022-04-29 Alkermes, Inc. Biciklički inhibitori histon deacetilaze
US11225475B2 (en) 2017-08-07 2022-01-18 Alkermes, Inc. Substituted pyridines as inhibitors of histone deacetylase
CN108997202A (zh) * 2018-07-10 2018-12-14 湖南华腾制药有限公司 一种（5-三氟甲基-吡啶-2-基）-乙酸盐的制备方法
JP7319395B2 (ja) * 2019-06-14 2023-08-01 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１の阻害剤
JP2023501969A (ja) * 2019-10-31 2023-01-20 チェックメイト セラピューティクス インコーポレイテッド 軸索変性の予防または抑制用組成物
WO2022030589A1 (ja) * 2020-08-05 2022-02-10 国立大学法人北海道大学 単座配位尿素化合物を含む配位子とそれを含むホウ素化触媒

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WO2007045462A2 (de) 2005-10-19 2007-04-26 Grünenthal GmbH Neue vanilloid-rezeptor liganden und ihre verwendung zur herstellung von arzneimitteln
DE102007018151A1 (de) 2007-04-16 2008-10-23 Günenthal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
AU2008238250B2 (en) 2007-04-16 2013-01-24 Grunenthal Gmbh Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals
HK1198697A1 (en) * 2011-07-26 2015-05-29 Grünenthal GmbH Substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands

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MX2014000964A (es) 2014-03-27
JP2014521618A (ja) 2014-08-28
CA2842983A1 (en) 2013-01-31
AU2012289255A1 (en) 2014-01-30
US20130029961A1 (en) 2013-01-31
AR087302A1 (es) 2014-03-12
KR20140049027A (ko) 2014-04-24
EP2736882A1 (en) 2014-06-04

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