BR112015008564A2 - derivados de 6-aminoindol como antagonistas de canal trp - Google Patents

derivados de 6-aminoindol como antagonistas de canal trp

Info

Publication number
BR112015008564A2
BR112015008564A2 BR112015008564A BR112015008564A BR112015008564A2 BR 112015008564 A2 BR112015008564 A2 BR 112015008564A2 BR 112015008564 A BR112015008564 A BR 112015008564A BR 112015008564 A BR112015008564 A BR 112015008564A BR 112015008564 A2 BR112015008564 A2 BR 112015008564A2
Authority
BR
Brazil
Prior art keywords
channel antagonists
trp channel
compounds
aminoindole derivatives
formula
Prior art date
Application number
BR112015008564A
Other languages
English (en)
Inventor
David Erickson Shawn
Chen Zhi
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112015008564A2 publication Critical patent/BR112015008564A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)

Abstract

1/1 resumo derivados de 6-aminoindol como antagonistas de canal trp a invenção se refere aos compostos da fórmula (i) e sais farmaceuticamente aceitáveis dos mesmos. além disso, a presente invenção se refere a métodos de fabricar e utilizar os compostos da fórmula (i) bem como composições farmacêuticas contendo tais compostos. os compostos da fórmula (i) podem ser usados como medicamento.
BR112015008564A 2012-10-17 2013-10-14 derivados de 6-aminoindol como antagonistas de canal trp BR112015008564A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261714957P 2012-10-17 2012-10-17
PCT/EP2013/071377 WO2014060328A1 (en) 2012-10-17 2013-10-14 6-aminoindole derivatives as trp channel antagonists

Publications (1)

Publication Number Publication Date
BR112015008564A2 true BR112015008564A2 (pt) 2017-07-04

Family

ID=49385243

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015008564A BR112015008564A2 (pt) 2012-10-17 2013-10-14 derivados de 6-aminoindol como antagonistas de canal trp

Country Status (11)

Country Link
US (1) US9388166B2 (pt)
EP (1) EP2909172A1 (pt)
JP (1) JP2015534957A (pt)
KR (1) KR20150070290A (pt)
CN (1) CN104755461A (pt)
BR (1) BR112015008564A2 (pt)
CA (1) CA2888369A1 (pt)
HK (1) HK1207379A1 (pt)
MX (1) MX2015004500A (pt)
RU (1) RU2015115677A (pt)
WO (1) WO2014060328A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107001267A (zh) * 2014-08-08 2017-08-01 马合伙人株式会社 稠合杂环化合物
TWI752155B (zh) 2017-02-01 2022-01-11 德商菲尼克斯製藥股份有限公司 芳香烴受體(AhR)調節劑化合物
TWI674260B (zh) 2017-02-01 2019-10-11 德商菲尼克斯製藥股份有限公司 芳基烴受體(AhR)調節劑化合物
TW201835070A (zh) * 2017-02-21 2018-10-01 德商菲尼克斯製藥股份有限公司 芳香烴受體(AhR)調節劑化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003270426A1 (en) * 2002-09-12 2004-04-30 Avanir Pharmaceuticals PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
SI1986633T1 (sl) * 2006-02-10 2015-03-31 Summit Corporation Plc Zdravljenje Duchennove mišične distrofije
DK2170396T3 (en) * 2007-08-03 2017-03-13 Summit Therapeutics Plc PHARMACEUTICAL COMBINATIONS TO TREAT THE MUSCLE DYROPHY OF DUCHENNES
CN102427729B (zh) * 2009-03-27 2014-09-03 默沙东公司 丙型肝炎病毒复制的抑制剂
JP2013505913A (ja) * 2009-09-24 2013-02-21 エフ．ホフマン−ラ ロシュ アーゲー Ｃｒａｃ調節剤としてのインドール誘導体
WO2011091407A1 (en) * 2010-01-25 2011-07-28 Glaxosmithkline Llp Trpv4 antagonists
CN103201262B (zh) * 2010-08-20 2016-06-01 艾米拉医药股份有限公司 自分泌运动因子抑制剂及其用途

Also Published As

Publication number Publication date
WO2014060328A1 (en) 2014-04-24
CN104755461A (zh) 2015-07-01
MX2015004500A (es) 2015-07-06
HK1207379A1 (en) 2016-01-29
US20150218133A1 (en) 2015-08-06
CA2888369A1 (en) 2014-04-24
EP2909172A1 (en) 2015-08-26
KR20150070290A (ko) 2015-06-24
JP2015534957A (ja) 2015-12-07
RU2015115677A (ru) 2016-12-10
US9388166B2 (en) 2016-07-12

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired