BR112015014687A2 - compostos de piridazina bicíclicos fundidos substituídos por arila - Google Patents
compostos de piridazina bicíclicos fundidos substituídos por arilaInfo
- Publication number
- BR112015014687A2 BR112015014687A2 BR112015014687A BR112015014687A BR112015014687A2 BR 112015014687 A2 BR112015014687 A2 BR 112015014687A2 BR 112015014687 A BR112015014687 A BR 112015014687A BR 112015014687 A BR112015014687 A BR 112015014687A BR 112015014687 A2 BR112015014687 A2 BR 112015014687A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- aryl substituted
- fused bicyclic
- substituted fused
- formula
- Prior art date
Links
- 125000003118 aryl group Chemical group 0.000 title abstract 2
- -1 bicyclic pyridazine compounds Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 102000020233 phosphotransferase Human genes 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
abstract the present invention provides a compound of formula (i): (i) as described herein, and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, or racemates thereof. also provided are methods of treating a disease or condition mediated by pim kinase using the compounds of formula i, and pharmaceutical compositions comprising such compounds. tradução do resumo resumo patente de invenção para "compostos de piridazina bicíclicos fundidos substituídos por arila". a presente invenção fornece um composto de fórmula (i): (i) como descrito aqui, e sais farmaceuticamente aceitáveis, enantiômeros, rotâmeros, tautômeros, ou racematos dos mesmos. da mesma fornecidos são os métodos de tratar uma doença ou condição mediada por pim cinase usando os compostos de fórmula (i), e composição farmacêuticas compreendendo tais compostos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261739522P | 2012-12-19 | 2012-12-19 | |
| PCT/US2013/075613 WO2014099880A1 (en) | 2012-12-19 | 2013-12-17 | Aryl-substituted fused bicyclic pyridazine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015014687A2 true BR112015014687A2 (pt) | 2017-07-11 |
Family
ID=49918880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015014687A BR112015014687A2 (pt) | 2012-12-19 | 2013-12-17 | compostos de piridazina bicíclicos fundidos substituídos por arila |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20150336960A1 (pt) |
| EP (1) | EP2935270A1 (pt) |
| KR (1) | KR20150095928A (pt) |
| AU (1) | AU2013363047A1 (pt) |
| BR (1) | BR112015014687A2 (pt) |
| CA (1) | CA2895338A1 (pt) |
| WO (1) | WO2014099880A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2943485B1 (en) | 2013-01-14 | 2017-09-20 | Incyte Holdings Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
| ME03780B (me) | 2013-01-15 | 2021-04-20 | Incyte Holdings Corp | Jedinjenja tiazolkarboksamida i piridinkarboksamida korisna kao inhibitori pim kinaze |
| TW201605866A (zh) | 2013-08-23 | 2016-02-16 | 英塞特公司 | 可用作ｐｉｍ激酶抑制劑之呋喃并－及噻吩并－吡啶甲醯胺化合物 |
| WO2016010897A1 (en) * | 2014-07-14 | 2016-01-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| JO3589B1 (ar) | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
| WO2016196244A1 (en) * | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| US11319320B2 (en) | 2017-11-06 | 2022-05-03 | Snap Bio, Inc. | PIM kinase inhibitor compositions, methods, and uses thereof |
| US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| JP5252404B2 (ja) | 2006-08-16 | 2013-07-31 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ピラジン化合物、その使用及び調製方法 |
| ES2431163T3 (es) | 2007-03-01 | 2013-11-25 | Novartis Ag | Inhibidores de PIM quinasa y métodos para su uso |
| WO2010026124A1 (en) | 2008-09-02 | 2010-03-11 | Novartis Ag | Picolinamide derivatives as kinase inhibitors |
| EA201290957A1 (ru) | 2010-04-07 | 2013-04-30 | Ф.Хоффманн-Ля Рош Аг | Пиразол-4-илгетероциклилкарбоксамидные соединения и способы их применения |
| JP2013530199A (ja) | 2010-07-06 | 2013-07-25 | ノバルティス アーゲー | キナーゼ阻害剤として有用な環状エーテル化合物 |
| UY33930A (es) | 2011-03-04 | 2012-10-31 | Novartis Ag | Inhibidores novedosos de quinasas |
| JP2014506915A (ja) | 2011-03-04 | 2014-03-20 | ノバルティス アーゲー | キナーゼ阻害剤としての四置換シクロヘキシル化合物 |
| US9187486B2 (en) | 2011-04-29 | 2015-11-17 | Amgen Inc. | Bicyclic pyridazine compounds as Pim inhibitors |
-
2013
- 2013-12-07 US US14/651,996 patent/US20150336960A1/en not_active Abandoned
- 2013-12-17 EP EP13818112.8A patent/EP2935270A1/en not_active Ceased
- 2013-12-17 CA CA2895338A patent/CA2895338A1/en not_active Abandoned
- 2013-12-17 WO PCT/US2013/075613 patent/WO2014099880A1/en not_active Ceased
- 2013-12-17 BR BR112015014687A patent/BR112015014687A2/pt not_active IP Right Cessation
- 2013-12-17 AU AU2013363047A patent/AU2013363047A1/en not_active Abandoned
- 2013-12-17 KR KR1020157019414A patent/KR20150095928A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013363047A1 (en) | 2015-07-09 |
| CA2895338A1 (en) | 2014-06-26 |
| EP2935270A1 (en) | 2015-10-28 |
| US20150336960A1 (en) | 2015-11-26 |
| KR20150095928A (ko) | 2015-08-21 |
| WO2014099880A1 (en) | 2014-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: dismissal - article 86 of industrial property law | ||
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |