BR112015020002A2 - sistema e método implementado por computador para proporcionar estimativa em tempo real de hemoglobina glicosilada (hbalc) de paciente e meio não transitório capaz de ser lido por computador - Google Patents

sistema e método implementado por computador para proporcionar estimativa em tempo real de hemoglobina glicosilada (hbalc) de paciente e meio não transitório capaz de ser lido por computador

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Publication number
BR112015020002A2
BR112015020002A2 BR112015020002A BR112015020002A BR112015020002A2 BR 112015020002 A2 BR112015020002 A2 BR 112015020002A2 BR 112015020002 A BR112015020002 A BR 112015020002A BR 112015020002 A BR112015020002 A BR 112015020002A BR 112015020002 A2 BR112015020002 A2 BR 112015020002A2
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BR
Brazil
Prior art keywords
hbalc
computer
time estimation
smbg
glycosylated hemoglobin
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BR112015020002A
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English (en)
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BR112015020002B1 (pt
Inventor
P Kovatchev Boris
D Breton Marc
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Univ Virginia Patent Foundation
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Publication date
Application filed by Univ Virginia Patent Foundation filed Critical Univ Virginia Patent Foundation
Publication of BR112015020002A2 publication Critical patent/BR112015020002A2/pt
Publication of BR112015020002B1 publication Critical patent/BR112015020002B1/pt

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • A61B5/7267—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems involving training the classification device
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Artificial Intelligence (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Physiology (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Optics & Photonics (AREA)

Abstract

“sistema e método implementado por computador para proporcionar estimativa em tempo real de hemoglobina glicosilada (hbalc) de paciente e meio não transitório capaz de ser lido por computador” resumo um método, sistema e meio capaz de ser lido por computador para o rastreio de mudanças em glicemia média em diabetes é baseado em uma abordagem conceitualmente nova para a recuperação de dados de smbg. ao se usar o entendimento de flutuação de hbalc como o efeito mensurável da ação de um sistema dinâmico subjacente, smbg proporciona vislumbres ocasionais no estado do referido sistema e, com o uso das referidas medições, a trajetória do sistema subjacente oculto pode ser reconstruída para pacientes diabéticos individuais. utilizando modelagem de compartimentos, um novo algoritmo de duas etapas é proporcionado, que inclui: (i) estimativa em tempo real de hbalc a partir de leituras em jejum de glicose, atualizadas com qualquer novo(s) ponto(s) de dados de smbg em jejum que entram e (ii) inicialização e calibração dos traços de hbalc estimados com perfis diários de smbg obtidos periodicamente. a estimativa dos referidos perfis inclui um modelo fatorial que captura a variabilidade de bg diária dentro de dois fatores latentes. 1/1
BR112015020002-8A 2013-02-21 2014-02-21 Sistema e método implementado por computador para proporcionar estimativa em tempo real de hemoglobina glicosilada (hbalc) de paciente e meio não transitório capaz de ser lido por computador BR112015020002B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361767451P 2013-02-21 2013-02-21
US61/767,451 2013-02-21
PCT/US2014/017754 WO2014130841A1 (en) 2013-02-21 2014-02-21 Tracking changes in average glycemia in diabetics

Publications (2)

Publication Number Publication Date
BR112015020002A2 true BR112015020002A2 (pt) 2017-07-18
BR112015020002B1 BR112015020002B1 (pt) 2022-07-12

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BR112015020002-8A BR112015020002B1 (pt) 2013-02-21 2014-02-21 Sistema e método implementado por computador para proporcionar estimativa em tempo real de hemoglobina glicosilada (hbalc) de paciente e meio não transitório capaz de ser lido por computador

Country Status (12)

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US (2) US10332615B2 (pt)
EP (1) EP2959009B1 (pt)
JP (1) JP6445466B2 (pt)
CN (1) CN105190316B (pt)
AU (2) AU2014218785A1 (pt)
BR (1) BR112015020002B1 (pt)
CA (1) CA2902042C (pt)
ES (1) ES2748399T3 (pt)
HK (1) HK1218938A1 (pt)
PH (1) PH12015501842A1 (pt)
RU (1) RU2640172C2 (pt)
WO (1) WO2014130841A1 (pt)

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JP7282298B2 (ja) * 2019-07-31 2023-05-29 アークレイ株式会社 推定方法及び平均血糖値推定システム
JP2023502534A (ja) * 2019-11-25 2023-01-24 アボット ダイアベティス ケア インコーポレイテッド 生理学的パラメータ分析のための方法、デバイス及びシステム
US12205686B2 (en) * 2020-02-27 2025-01-21 The Cleveland Clinic Foundation Identifying patients for intensive hyperglycemia management
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Also Published As

Publication number Publication date
US11842817B2 (en) 2023-12-12
CN105190316A (zh) 2015-12-23
JP6445466B2 (ja) 2018-12-26
EP2959009B1 (en) 2019-07-31
PH12015501842A1 (en) 2015-11-09
US20160004813A1 (en) 2016-01-07
EP2959009A4 (en) 2016-11-09
ES2748399T3 (es) 2020-03-16
CA2902042C (en) 2021-09-07
AU2020201546A1 (en) 2020-03-19
US20190318801A1 (en) 2019-10-17
JP2016511038A (ja) 2016-04-14
CN105190316B (zh) 2019-06-11
RU2015136919A (ru) 2017-03-30
EP2959009A1 (en) 2015-12-30
WO2014130841A1 (en) 2014-08-28
BR112015020002B1 (pt) 2022-07-12
AU2020201546B2 (en) 2021-10-28
AU2014218785A1 (en) 2015-09-10
HK1218938A1 (zh) 2017-03-17
US10332615B2 (en) 2019-06-25
CA2902042A1 (en) 2014-08-28
RU2640172C2 (ru) 2017-12-26

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