BR112018017172A2 - anti-alpha-synuclein monoclonal antibodies for prevention of tau aggregation - Google Patents

anti-alpha-synuclein monoclonal antibodies for prevention of tau aggregation

Info

Publication number
BR112018017172A2
BR112018017172A2 BR112018017172A BR112018017172A BR112018017172A2 BR 112018017172 A2 BR112018017172 A2 BR 112018017172A2 BR 112018017172 A BR112018017172 A BR 112018017172A BR 112018017172 A BR112018017172 A BR 112018017172A BR 112018017172 A2 BR112018017172 A2 BR 112018017172A2
Authority
BR
Brazil
Prior art keywords
alpha
monoclonal antibodies
prevention
tau aggregation
synuclein monoclonal
Prior art date
Application number
BR112018017172A
Other languages
Portuguese (pt)
Inventor
Falsig Pedersen Jeppe
Fog Karina
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of BR112018017172A2 publication Critical patent/BR112018017172A2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

anticorpos monoclonais anti-alfa-sinucleína para prevenção da agregação de tau a invenção se relaciona com um novo uso de anticorpos monoclonais anti-alfa-sinucleína. os anticorpos podem ser usados para prevenir a agregação de tau e, desse modo, tratar tauopatias tais como doença de alzheimer.Anti-Alpha-Synuclein Monoclonal Antibodies to Prevent Aggregation of Tau The invention relates to a novel use of anti-alpha-synuclein monoclonal antibodies. Antibodies can be used to prevent tau aggregation and thereby treat tauopathies such as alzheimer's disease.

BR112018017172A 2016-12-22 2017-12-21 anti-alpha-synuclein monoclonal antibodies for prevention of tau aggregation BR112018017172A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201600782 2016-12-22
DKPA201700016 2017-01-05
PCT/EP2017/083994 WO2018115225A1 (en) 2016-12-22 2017-12-21 Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation

Publications (1)

Publication Number Publication Date
BR112018017172A2 true BR112018017172A2 (en) 2019-01-02

Family

ID=61022287

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018017172A BR112018017172A2 (en) 2016-12-22 2017-12-21 anti-alpha-synuclein monoclonal antibodies for prevention of tau aggregation

Country Status (14)

Country Link
US (1) US10364286B2 (en)
EP (1) EP3558364A1 (en)
JP (1) JP7300990B2 (en)
KR (1) KR102584663B1 (en)
CN (1) CN110114088B (en)
AU (1) AU2017384681B2 (en)
BR (1) BR112018017172A2 (en)
CA (1) CA3046857A1 (en)
CL (1) CL2019001735A1 (en)
CO (1) CO2019006059A2 (en)
IL (1) IL267559A (en)
MX (1) MX2019007480A (en)
RU (1) RU2760334C2 (en)
WO (1) WO2018115225A1 (en)

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GB201512203D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
NZ748983A (en) 2016-07-12 2022-12-23 H Lundbeck As Antibodies specific for hyperphosphorylated tau and methods of use thereof
US10889635B2 (en) 2016-11-15 2021-01-12 H. Lundbeck A/S Agents, uses and methods for the treatment of synucleinopathy
BR112018016717A2 (en) 2016-12-16 2018-12-26 H Lundbeck As agents, uses and methods
JP7217710B2 (en) 2017-01-04 2023-02-03 ハー・ルンドベック・アクチエゼルスカベット Antibodies specific for hyperphosphorylated tau for the treatment of eye diseases
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JP2023528797A (en) 2020-05-26 2023-07-06 トゥルーバインディング，インコーポレイテッド Methods of treating inflammatory diseases by blocking galectin-3
KR102239512B1 (en) * 2020-09-10 2021-04-12 서울대학교산학협력단 Multi-functional microcapsule composition and manufacturing method of the same
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Also Published As

Publication number Publication date
RU2019118922A3 (en) 2021-04-22
AU2017384681B2 (en) 2024-06-13
KR102584663B1 (en) 2023-10-04
WO2018115225A1 (en) 2018-06-28
MX2019007480A (en) 2019-08-29
EP3558364A1 (en) 2019-10-30
AU2017384681A1 (en) 2019-07-04
CN110114088A (en) 2019-08-09
IL267559A (en) 2019-08-29
JP7300990B2 (en) 2023-06-30
CA3046857A1 (en) 2018-06-28
RU2760334C2 (en) 2021-11-24
US20180179273A1 (en) 2018-06-28
US10364286B2 (en) 2019-07-30
CO2019006059A2 (en) 2019-06-19
KR20190098976A (en) 2019-08-23
JP2020504729A (en) 2020-02-13
CN110114088B (en) 2023-08-15
RU2019118922A (en) 2021-01-22
CL2019001735A1 (en) 2019-10-04

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