BR112022015236A2 - Composições de células t do receptor de antígeno quimérico direcionado a cd19 e métodos e usos das mesmas - Google Patents

Composições de células t do receptor de antígeno quimérico direcionado a cd19 e métodos e usos das mesmas

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Publication number
BR112022015236A2
BR112022015236A2 BR112022015236A BR112022015236A BR112022015236A2 BR 112022015236 A2 BR112022015236 A2 BR 112022015236A2 BR 112022015236 A BR112022015236 A BR 112022015236A BR 112022015236 A BR112022015236 A BR 112022015236A BR 112022015236 A2 BR112022015236 A2 BR 112022015236A2
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BR
Brazil
Prior art keywords
compositions
cells
methods
antigen receptor
lymphoma
Prior art date
Application number
BR112022015236A
Other languages
English (en)
Inventor
Amanda SALMON Ruth
Westoby Matthew
Wrangham Briggs Adrian
G Kugler David
Guy Caspary Robert
Chan Calvin
Varun Divya
Germeroth Lothar
Stemberger Christian
Pawel Poltorak Mateusz
Bashour Keenan
Baturevych Oleksandr
Kilavuz Nurgul
Hege Kristen
Burgess Michael
Wu Kaida
Original Assignee
Juno Therapeutics Inc
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Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of BR112022015236A2 publication Critical patent/BR112022015236A2/pt

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
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    • A61K39/0011—Cancer antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61K40/4211—CD19 or B4
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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Abstract

COMPOSIÇÕES DE CÉLULAS T DO RECEPTOR DE ANTÍGENO QUIMÉRICO DIRECIONADO A CD19 E MÉTODOS E USOS DAS MESMAS. Em alguns aspectos, são fornecidas composições de células para o tratamento de indivíduos com doenças e condições, como linfoma não Hodgkin (NHL), e métodos, composições, usos e artigos de fabricação relacionados. Em algumas modalidades, a doença ou condição é um linfoma não Hodgkin de células B (NHL de células B). As células geralmente expressam receptores recombinantes, como receptores de antígeno quimérico (CARs) para direcionar um antígeno, como CD19, em células do linfoma.
BR112022015236A 2020-02-12 2021-02-11 Composições de células t do receptor de antígeno quimérico direcionado a cd19 e métodos e usos das mesmas BR112022015236A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062975724P 2020-02-12 2020-02-12
PCT/US2021/017739 WO2021163391A1 (en) 2020-02-12 2021-02-11 Cd19-directed chimeric antigen receptor t cell compositions and methods and uses thereof

Publications (1)

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BR112022015236A2 true BR112022015236A2 (pt) 2022-09-20

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Country Status (11)

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US (1) US20230190798A1 (pt)
EP (1) EP4103204A1 (pt)
JP (1) JP2023519098A (pt)
KR (1) KR20220152220A (pt)
CN (1) CN115768443A (pt)
AU (1) AU2021220875A1 (pt)
BR (1) BR112022015236A2 (pt)
CA (1) CA3169672A1 (pt)
IL (1) IL295384B1 (pt)
MX (1) MX2022009832A (pt)
WO (1) WO2021163391A1 (pt)

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SG11202101204TA (en) 2018-08-09 2021-03-30 Juno Therapeutics Inc Processes for generating engineered cells and compositions thereof
WO2020180882A1 (en) 2019-03-05 2020-09-10 Nkarta, Inc. Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy
WO2024097315A2 (en) * 2022-11-02 2024-05-10 Sana Biotechnology, Inc. Cell therapy products and methods for producing same
WO2024206898A1 (en) * 2023-03-30 2024-10-03 Cabaletta Bio, Inc. Methods and compositions for treating autoimmune diseases
US20240368273A1 (en) * 2023-05-03 2024-11-07 PELL Bio-Med Technology Co., Ltd. Murine anti-cd19 chimeric antigen receptor for treating cancer
KR20250074841A (ko) * 2023-11-20 2025-05-28 (재) 스크립스코리아항체연구원 키메라 항원 수용체를 발현하는 면역 세포 및 트렙타비딘 스캐폴드 항체 유사 단백질을 포함하는 항암용 조성물, 및 이의 용도

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