BR112022016212A2 - Método para detectar tumor ovariano maligno, e, uso de um anticorpo - Google Patents

Método para detectar tumor ovariano maligno, e, uso de um anticorpo

Info

Publication number
BR112022016212A2
BR112022016212A2 BR112022016212A BR112022016212A BR112022016212A2 BR 112022016212 A2 BR112022016212 A2 BR 112022016212A2 BR 112022016212 A BR112022016212 A BR 112022016212A BR 112022016212 A BR112022016212 A BR 112022016212A BR 112022016212 A2 BR112022016212 A2 BR 112022016212A2
Authority
BR
Brazil
Prior art keywords
ovarian tumors
antibody
malignant ovarian
distinct
tfpi2
Prior art date
Application number
BR112022016212A
Other languages
English (en)
Inventor
Miyagi Etsuko
Arakawa Noriaki
Ohtake Norihisa
Myoba Shohei
Original Assignee
Public Univ Corp Yokohama City Univ
Tosoh Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Public Univ Corp Yokohama City Univ, Tosoh Corp filed Critical Public Univ Corp Yokohama City Univ
Publication of BR112022016212A2 publication Critical patent/BR112022016212A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57545—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the ovaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G01N2333/4704—Inhibitors; Supressors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8114—Kunitz type inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

MÉTODO PARA DETECTAR TUMOR OVARIANO MALIGNO, E, USO DE UM ANTICORPO. A presente invenção aborda o problema de prover um método para detectar tumores ovarianos malignos distintamente de tumores ovarianos benignos e um reagente que pode ser usado no método. Este método para detectar tumores ovarianos malignos (excluindo carcinoma seroso de alto grau) distintamente de tumores ovarianos benignos é distinguido pela quantidade de TFPI2 em uma amostra originária de um paciente ser medida. Além disso, um anticorpo que reconhece especificamente o polipeptídeo de processamento de TFPI2 e TFPI2 intacto é incluído em um reagente para detectar tumores ovarianos malignos (excluindo carcinoma seroso de alto grau) distintamente de tumores ovarianos benignos.
BR112022016212A 2020-02-26 2021-02-09 Método para detectar tumor ovariano maligno, e, uso de um anticorpo BR112022016212A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020030210 2020-02-26
PCT/JP2021/004736 WO2021172000A1 (ja) 2020-02-26 2021-02-09 卵巣悪性腫瘍の検出方法及び検出試薬

Publications (1)

Publication Number Publication Date
BR112022016212A2 true BR112022016212A2 (pt) 2022-10-04

Family

ID=77490489

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022016212A BR112022016212A2 (pt) 2020-02-26 2021-02-09 Método para detectar tumor ovariano maligno, e, uso de um anticorpo

Country Status (8)

Country Link
US (1) US20230122642A1 (pt)
EP (1) EP4113119A4 (pt)
JP (1) JP7777304B2 (pt)
CN (1) CN115151821A (pt)
AU (1) AU2021227181A1 (pt)
BR (1) BR112022016212A2 (pt)
CA (1) CA3172404A1 (pt)
WO (1) WO2021172000A1 (pt)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003068054A2 (en) 2002-02-13 2003-08-21 The Government Of The United States Of America As Represented By The Secretary, Department Of Health Services Identification of ovarian cancer tumor markers and therapeutic targets
US7659062B2 (en) 2003-06-03 2010-02-09 The Board of Trustee of the University of Arkansas System Gene expression profiling of uterine serous papillary carcinomas and ovarian serous papillary tumors
JP4603548B2 (ja) * 2003-09-24 2010-12-22 オンコセラピー・サイエンス株式会社 Ｔｆｐｉ−２タンパク質を用いた卵巣子宮内膜症の診断法
JP5224308B2 (ja) 2010-02-22 2013-07-03 公立大学法人横浜市立大学 卵巣明細胞腺癌に特異的に発現しているタンパク質とその応用
JP5906447B2 (ja) * 2011-01-13 2016-04-20 国立研究開発法人産業技術総合研究所 上皮性卵巣癌鑑別マーカー
JP6074676B2 (ja) * 2011-08-19 2017-02-08 公立大学法人横浜市立大学 組織因子経路阻害因子２（ｔｆｐｉ２）測定による卵巣明細胞腺癌の検査方法および検査薬
US20170322218A1 (en) * 2014-11-27 2017-11-09 Public University Corporation Yokohama City University Method and reagent for detecting ovarian clear cell adenocarcinoma
JP6760562B2 (ja) * 2016-09-30 2020-09-23 公立大学法人横浜市立大学 卵巣明細胞癌患者の予後を予測するための情報提供方法
EP3657170A1 (en) * 2018-11-20 2020-05-27 Philipps-Universität Marburg Method for the early detection and diagnosis of primary and relapsed ovarian carcinoma (oc)

Also Published As

Publication number Publication date
CA3172404A1 (en) 2021-09-02
JP7777304B2 (ja) 2025-11-28
US20230122642A1 (en) 2023-04-20
CN115151821A (zh) 2022-10-04
JPWO2021172000A1 (pt) 2021-09-02
EP4113119A4 (en) 2024-03-06
AU2021227181A1 (en) 2022-09-22
WO2021172000A1 (ja) 2021-09-02
EP4113119A1 (en) 2023-01-04

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