BR112022017484A2 - Processo quimioenzimático para a preparação de um produto de glicose oxidada, processos quimioenzimáticos para a produção de ácido glucárico e para a produção de d-glucono-¿-1,5-lactona, e, processo de fabricação - Google Patents

Processo quimioenzimático para a preparação de um produto de glicose oxidada, processos quimioenzimáticos para a produção de ácido glucárico e para a produção de d-glucono-¿-1,5-lactona, e, processo de fabricação

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Publication number
BR112022017484A2
BR112022017484A2 BR112022017484A BR112022017484A BR112022017484A2 BR 112022017484 A2 BR112022017484 A2 BR 112022017484A2 BR 112022017484 A BR112022017484 A BR 112022017484A BR 112022017484 A BR112022017484 A BR 112022017484A BR 112022017484 A2 BR112022017484 A2 BR 112022017484A2
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BR
Brazil
Prior art keywords
chemioenzymatic
production
peroxidase
oxidized
oxidase
Prior art date
Application number
BR112022017484A
Other languages
English (en)
Inventor
M Lee Toni
Qian Shuai
F Fisher Brian
Downing Sarah
Chakrabarti Gaurab
Hunt Sean
Original Assignee
Solugen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solugen Inc filed Critical Solugen Inc
Publication of BR112022017484A2 publication Critical patent/BR112022017484A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
    • C12Y101/03004—Glucose oxidase (1.1.3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
    • C12Y101/03009—Galactose oxidase (1.1.3.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01—Peroxidases (1.11.1)
    • C12Y111/01007—Peroxidase (1.11.1.7), i.e. horseradish-peroxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/99—Miscellaneous (1.14.99)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCESSO QUIMIOENZIMÁTICO PARA A PREPARAÇÃO DE UM PRODUTO DE GLICOSE OXIDADA, PROCESSOS QUIMIOENZIMÁTICOS PARA A PRODUÇÃO DE ÁCIDO GLUCÁRICO E PARA A PRODUÇÃO DE D-GLUCONO-d-1,5-LACTONA, E, PROCESSO DE FABRICAÇÃO. Um processo quimioenzimático para a preparação de um produto de glicose oxidada que compreende colocar a D-glicose em contato com uma enzima selecionada a partir do grupo que consiste essencialmente em galactose oxidase (GAO), glicose oxidase (GOX), polissacarídeo monooxigenase, catalase, peroxidase animal, aldeído oxidase periplasmática (Pao), peroxigenase inespecífica (UPO), lactoperoxidase (LPO), mieloperoxidase (MPO), peroxidase eosinofílica (EPO), peroxidase tireoidiana (TPO), ovoperoxidase, peroxidase salivar, haloperoxidase de vanádio, peroxidase de vertebrados não mamíferos (POX), peroxidasina (Pxd), peroxicina bacteriana (Pxc), peroxinectina de invertebrados (Pxt), peroxidoquerina curta (PxDo), alfa-dioxigenase (aDox), dupla oxidase (DuOx), prostaglandina H sintase (PGHS), ciclooxigenase (CyOx), linoleato diol sintase (LDS), variantes dos mesmos e combinações dos mesmos em condições adequadas para a formação de um intermediário oxidado; e colocar o intermediário oxidado em contato com um catalisador de metal para formar um produto de glicose oxidada.
BR112022017484A 2020-03-06 2021-03-06 Processo quimioenzimático para a preparação de um produto de glicose oxidada, processos quimioenzimáticos para a produção de ácido glucárico e para a produção de d-glucono-¿-1,5-lactona, e, processo de fabricação BR112022017484A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062986447P 2020-03-06 2020-03-06
PCT/US2021/021261 WO2021178935A1 (en) 2020-03-06 2021-03-06 Compositions and methods for production of glucose oxidation products

Publications (1)

Publication Number Publication Date
BR112022017484A2 true BR112022017484A2 (pt) 2022-11-16

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BR112022017484A BR112022017484A2 (pt) 2020-03-06 2021-03-06 Processo quimioenzimático para a preparação de um produto de glicose oxidada, processos quimioenzimáticos para a produção de ácido glucárico e para a produção de d-glucono-¿-1,5-lactona, e, processo de fabricação

Country Status (10)

Country Link
US (1) US20230121990A1 (pt)
EP (1) EP4114930A4 (pt)
JP (1) JP2023516761A (pt)
KR (1) KR20220151666A (pt)
CN (1) CN115397977A (pt)
AU (1) AU2021231903A1 (pt)
BR (1) BR112022017484A2 (pt)
CA (1) CA3170300A1 (pt)
MX (1) MX2022011053A (pt)
WO (1) WO2021178935A1 (pt)

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* Cited by examiner, † Cited by third party
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JPWO2022114031A1 (pt) * 2020-11-25 2022-06-02
CA3226379A1 (en) * 2021-07-22 2023-01-26 Toni M. Lee Compositions and methods for production of value-added chemicals
WO2024129887A1 (en) * 2022-12-13 2024-06-20 Solugen, Inc. Biobased synthesis of glucodiamine
WO2024160906A1 (en) * 2023-02-01 2024-08-08 Coöperatie Koninklijke Cosun U.A. Enzymatic process for the production of aldaric acids
WO2024249896A1 (en) * 2023-06-01 2024-12-05 Solugen, Inc. Methods and compositions for the production of glyoxal
WO2025034669A1 (en) * 2023-08-04 2025-02-13 Solugen, Inc. Methods for the production of high purity glucaric acid
WO2025076549A1 (en) * 2023-10-06 2025-04-10 Solugen, Inc. Small molecule activators
WO2025098128A1 (en) * 2023-11-06 2025-05-15 Enzymaster (Ningbo) Bio-Engineering Co., Ltd. A method of synthesizing glucaric acid and the enzymes used thereof
WO2026019839A1 (en) * 2024-07-15 2026-01-22 Solugen, Inc. Systems and methods for producing 2,5-furandicarboxylic acid

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US7220563B2 (en) * 2002-02-27 2007-05-22 California Institute Of Technology Glucose 6-oxidases
DE10362249B4 (de) * 2003-05-05 2014-05-15 Südzucker AG Mannheim/Ochsenfurt C1-selektive Oxidation von Oligosacchariden und die Verwendung eines Kohlenstoff geträgerten Gold-Katalysators für diese Oxidation
WO2005059152A1 (en) * 2003-12-18 2005-06-30 Cerestar Holding B.V. Oxidation of carbohydrates by means of peroxidases and nitroxy radicals
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CN105026548B (zh) * 2012-06-04 2019-06-18 盐水港精糖株式会社 D-葡萄糖二酸生产菌及d-葡萄糖二酸的制造方法
CN104781412A (zh) * 2012-07-20 2015-07-15 诺维信公司 5-羟甲基糠醛及其衍生物的酶氧化
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CN104837556B (zh) * 2012-10-05 2018-04-03 康奈尔大学 包埋在大孔支架中的酶形成的介孔集合
JP6290756B2 (ja) * 2014-09-17 2018-03-07 旭化成株式会社 一級アルコールからカルボキシル基を二つ以上持つ化合物を製造する方法、およびそれに用いる触媒
DK3200891T3 (da) * 2014-09-29 2020-11-16 Archer Daniels Midland Co Fremstilling og separering af en dicarboxylsyre-indeholdende blanding under anvendelse af en dicarboxylatform af et anionbytterkromatografiresin
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MX2022011053A (es) 2023-03-14
US20230121990A1 (en) 2023-04-20
CN115397977A (zh) 2022-11-25
EP4114930A1 (en) 2023-01-11
WO2021178935A1 (en) 2021-09-10
CA3170300A1 (en) 2021-09-10
JP2023516761A (ja) 2023-04-20
KR20220151666A (ko) 2022-11-15
AU2021231903A1 (en) 2022-09-29
EP4114930A4 (en) 2024-04-10

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