BR9305907A - Uso de derivados de substituída para tratamento de esclerose múltipla - Google Patents

Uso de derivados de substituída para tratamento de esclerose múltipla

Info

Publication number
BR9305907A
BR9305907A BR9305907A BR9305907A BR9305907A BR 9305907 A BR9305907 A BR 9305907A BR 9305907 A BR9305907 A BR 9305907A BR 9305907 A BR9305907 A BR 9305907A BR 9305907 A BR9305907 A BR 9305907A
Authority
BR
Brazil
Prior art keywords
multiple sclerosis
treatment
substituted derivatives
formula
represented
Prior art date
Application number
BR9305907A
Other languages
English (en)
Inventor
Ernest Beutler
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of BR9305907A publication Critical patent/BR9305907A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BR9305907A 1992-02-19 1993-02-18 Uso de derivados de substituída para tratamento de esclerose múltipla BR9305907A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/838,546 US5310732A (en) 1986-02-03 1992-02-19 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
PCT/US1993/001467 WO1993016706A1 (en) 1992-02-19 1993-02-18 Use of substituted adenine derivatives for treating multiple sclerosis

Publications (1)

Publication Number Publication Date
BR9305907A true BR9305907A (pt) 1997-10-21

Family

ID=25277387

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9305907A BR9305907A (pt) 1992-02-19 1993-02-18 Uso de derivados de substituída para tratamento de esclerose múltipla

Country Status (15)

Country Link
US (4) US5310732A (pt)
EP (1) EP0626853B1 (pt)
JP (1) JP2688113B2 (pt)
AT (1) ATE192045T1 (pt)
AU (1) AU682818B2 (pt)
BR (1) BR9305907A (pt)
CA (1) CA2130275C (pt)
CH (1) CH684310A5 (pt)
DE (1) DE69328474T2 (pt)
DK (1) DK0626853T3 (pt)
FI (1) FI943805L (pt)
HU (1) HU218656B (pt)
NO (2) NO309025B1 (pt)
RU (1) RU2130308C1 (pt)
WO (1) WO1993016706A1 (pt)

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US7094597B1 (en) 1994-05-20 2006-08-22 The Regents Of The University Of California Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis
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AU7470794A (en) * 1994-05-26 1995-12-21 Scripps Research Institute, The 2-halo-2'-deoxyadenosine treatement for inflammatory bowel disease
US6060501A (en) * 1994-06-02 2000-05-09 Schering Aktiengesellschaft Combined treatment of multiple sclerosis
US5817641A (en) * 1994-07-21 1998-10-06 Thomas Jefferson University Treatment of enterotoxigenic diarrhea with 2-substituted adenosine derivatives
US5510336A (en) * 1994-09-06 1996-04-23 Saven; Alan 2-halo-2'-deoxyadenosine treatment for histiocytosis
US5641757A (en) * 1994-12-21 1997-06-24 Ortho Pharmaceutical Corporation Stable 2-chloro-2'-deoxyadenosine formulations
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SK283821B6 (sk) * 1995-02-10 2004-02-03 Schering Aktiengesellschaft Farmaceutické preparáty na inhibíciu tumornekrózafaktora
US5811073A (en) * 1995-06-19 1998-09-22 President And Fellows Of Harvard College Method for radioisotopic detection and localization of inflammation in a host
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US6174873B1 (en) 1998-11-04 2001-01-16 Supergen, Inc. Oral administration of adenosine analogs
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US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
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US7608683B2 (en) * 2000-08-09 2009-10-27 The Regents Of The University Of California Stress proteins and peptides and methods of use thereof
US6989146B2 (en) * 2000-08-09 2006-01-24 The Regents Of The University Of California Stress proteins and peptides and methods of use thereof
EA005821B1 (ru) 2000-11-01 2005-06-30 Дзе Реджентс Оф Дзе Юниверсити Оф Калифорния Иммуномодулирующие пептиды, полученные из белков теплового шока, и их применение
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US7368423B1 (en) * 2001-12-05 2008-05-06 The Scripps Research Institute Composition and method for treating chronic allograft rejection
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UA81305C2 (en) 2003-07-02 2007-12-25 Ares Trading Sa Formulation of cladribine (variants), cladribine-cyclodextrin complex, use of cladribine-cyclodextrin complex, mixture
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DE602004006895T2 (de) * 2003-12-29 2008-01-31 Can-Fite Biopharma Ltd. Verfahren zur behandlung von multipler sklerose
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EP3608022A1 (en) 2013-03-15 2020-02-12 The Trustees of Princeton University Methods and devices for high throughput purification
EP3569313A1 (en) 2013-03-15 2019-11-20 GPB Scientific, LLC On-chip microfluidic processing of particles
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
GB201401465D0 (en) * 2014-01-29 2014-03-12 Roach Arthur H Use of cladribine for treating autoimmune inflammatory disease
JP2017534627A (ja) 2014-11-06 2017-11-24 ノースウエスタン ユニバーシティＮｏｒｔｈｗｅｓｔｅｒｎ Ｕｎｉｖｅｒｓｉｔｙ 癌細胞運動性の阻害
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
HK1250543A1 (zh) * 2015-08-24 2018-12-21 日本瑞翁株式会社 用於多步骤细胞纯化和浓缩的方法和装置
GB2564717A (en) 2017-07-21 2019-01-23 Chord Therapeutics S A R L Use of cladribine for treating autoimmune neuromuscular disease
EP3713582A1 (en) 2017-11-24 2020-09-30 Merck Patent GmbH Cladribine regimen for use intreating progressive forms of multiple sclerosis
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Also Published As

Publication number Publication date
DE69328474T2 (de) 2000-09-28
EP0626853A1 (en) 1994-12-07
ATE192045T1 (de) 2000-05-15
HU218656B (hu) 2000-10-28
NO322328B1 (no) 2006-09-18
US5310732A (en) 1994-05-10
DK0626853T3 (da) 2000-08-07
JPH07507540A (ja) 1995-08-24
JP2688113B2 (ja) 1997-12-08
CH684310A5 (de) 1994-08-31
US5506214A (en) 1996-04-09
US5506213A (en) 1996-04-09
US5541164A (en) 1996-07-30
WO1993016706A1 (en) 1993-09-02
CA2130275C (en) 1999-06-29
EP0626853B1 (en) 2000-04-26
AU3724993A (en) 1993-09-13
RU2130308C1 (ru) 1999-05-20
HUT68030A (en) 1995-05-29
NO20000762D0 (no) 2000-02-16
NO20000762L (no) 1994-09-13
AU682818B2 (en) 1997-10-23
NO942765L (no) 1994-09-13
NO942765D0 (no) 1994-07-25
FI943805A7 (fi) 1994-10-19
FI943805L (fi) 1994-10-19
FI943805A0 (fi) 1994-08-18
HU9402392D0 (en) 1994-10-28
RU94038043A (ru) 1996-11-20
NO309025B1 (no) 2000-12-04
DE69328474D1 (de) 2000-05-31
CA2130275A1 (en) 1993-09-02

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Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal
FC Decision: refusal