BR9707767A - Composto analgésico composição farmaceuticamente aceitável compreendendo o mesmo e utilização de um composto analgésico - Google Patents

Composto analgésico composição farmaceuticamente aceitável compreendendo o mesmo e utilização de um composto analgésico

Info

Publication number
BR9707767A
BR9707767A BR9707767A BR9707767A BR9707767A BR 9707767 A BR9707767 A BR 9707767A BR 9707767 A BR9707767 A BR 9707767A BR 9707767 A BR9707767 A BR 9707767A BR 9707767 A BR9707767 A BR 9707767A
Authority
BR
Brazil
Prior art keywords
alkyl
hydrogen
aralkyl
aryl
analgesic compound
Prior art date
Application number
BR9707767A
Other languages
English (en)
Inventor
John Dimaio
Wuyi Wang
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of BR9707767A publication Critical patent/BR9707767A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR9707767A 1996-02-28 1997-02-25 Composto analgésico composição farmaceuticamente aceitável compreendendo o mesmo e utilização de um composto analgésico BR9707767A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9600769A SE9600769D0 (sv) 1996-02-28 1996-02-28 Compounds useful as analgesic
PCT/SE1997/000315 WO1997031940A1 (en) 1996-02-28 1997-02-25 Isoquinolines useful as analgesics

Publications (1)

Publication Number Publication Date
BR9707767A true BR9707767A (pt) 1999-07-27

Family

ID=20401594

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9707767A BR9707767A (pt) 1996-02-28 1997-02-25 Composto analgésico composição farmaceuticamente aceitável compreendendo o mesmo e utilização de um composto analgésico

Country Status (20)

Country Link
US (1) US6034097A (pt)
EP (1) EP0914332B1 (pt)
JP (1) JP2000506138A (pt)
KR (1) KR19990087322A (pt)
CN (1) CN1211990A (pt)
AT (1) ATE217322T1 (pt)
AU (1) AU722032B2 (pt)
BR (1) BR9707767A (pt)
CA (1) CA2244219A1 (pt)
CZ (1) CZ272098A3 (pt)
DE (1) DE69712490D1 (pt)
EE (1) EE9800266A (pt)
IL (1) IL125925A0 (pt)
IS (1) IS4834A (pt)
NO (1) NO983945L (pt)
NZ (1) NZ331119A (pt)
PL (1) PL328734A1 (pt)
SE (1) SE9600769D0 (pt)
SK (1) SK113498A3 (pt)
WO (1) WO1997031940A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9604789D0 (sv) * 1996-12-20 1996-12-20 Astra Ab New Compounds
RU2221786C2 (ru) * 1999-02-04 2004-01-20 СК Корпорейшн Производные тетрагидроизохинолиналканола, способы лечения и фармацевтические композиции на их основе
CN1142913C (zh) * 1999-02-04 2004-03-24 Sk株式会社 四氢异喹啉烷醇衍生物及其药物组合物
IL144583A0 (en) * 2001-07-26 2002-05-23 Peptor Ltd Chimeric protein kinase inhibitors
JP4459629B2 (ja) 2002-04-12 2010-04-28 メルク エンド カムパニー インコーポレーテッド 二環式アミド
DE10312963A1 (de) * 2003-03-24 2004-10-07 Aventis Pharma Deutschland Gmbh Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament
IL156429A0 (en) * 2003-06-12 2004-01-04 Peptor Ltd Cell permeable conjugates of peptides for inhibition of protein kinases
CN100503571C (zh) 2006-07-12 2009-06-24 中国药科大学 四氢异喹啉类衍生物、其制备方法及其医药用途
WO2008016913A1 (en) * 2006-07-31 2008-02-07 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Biologically potent analogues of the dmt-tic pharmacophore and methods of use
US9623021B2 (en) * 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
WO2008091555A2 (en) 2007-01-22 2008-07-31 Gtx, Inc. Nuclear receptor binding agents
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
WO2011104649A1 (en) * 2010-02-25 2011-09-01 Pfizer Limited Peptide analogues
US9908887B2 (en) 2012-12-21 2018-03-06 Epizyme, Inc. PRMT5 inhibitors and uses thereof
JP2016505597A (ja) 2012-12-21 2016-02-25 エピザイム,インコーポレイティド Prmt5阻害剤およびその使用
US9745291B2 (en) 2012-12-21 2017-08-29 Epizyme, Inc. PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
US8993555B2 (en) 2012-12-21 2015-03-31 Epizyme, Inc. PRMT5 inhibitors and uses thereof
WO2014100716A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
CN103450079B (zh) * 2013-08-14 2015-07-29 中国药科大学 四氢异喹啉羟基衍生物、其制备方法及其医药用途
US10653693B2 (en) 2014-08-04 2020-05-19 Epizyme, Inc. PRMT5 inhibitors and uses thereof
WO2018129393A1 (en) * 2017-01-06 2018-07-12 The Regents Of The University Of California Mu opioid receptor modulators
JP7402857B2 (ja) 2018-04-04 2023-12-21 エピオダイン,インク. オピオイド受容体モジュレーター、およびそれに関連する生成物ならびに方法
TW202304869A (zh) 2021-04-05 2023-02-01 美商艾碧奧戴股份有限公司 類鴉片受體調節劑
CN115260096B (zh) * 2022-08-19 2024-04-09 武汉大学 一种基于一氧化碳气体或一氧化碳替代源合成二氢异喹啉酮类化合物的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599325A (en) * 1984-02-16 1986-07-08 G. D. Searle & Co. Substituted tyrosyl alanine dipeptide amides
US5648333A (en) * 1988-11-24 1997-07-15 Hoechst Aktiengesellschaft Peptides having bradykinin antagonist action
SE9300012D0 (sv) * 1993-01-05 1993-01-05 Astra Ab New peptides
CA2090171A1 (en) * 1993-02-23 1994-08-24 Peter W. Schiller Opioid receptor antagonists, their synthesis and use as analgesic and immunosuppressive compounds
CA2118985A1 (en) * 1993-04-02 1994-10-03 Dinesh V. Patel Heterocyclic inhibitors of farnesyl protein transferase
SE9402880D0 (sv) * 1994-08-30 1994-08-30 Astra Ab New peptide derivatives

Also Published As

Publication number Publication date
NO983945D0 (no) 1998-08-27
CZ272098A3 (cs) 1999-03-17
WO1997031940A1 (en) 1997-09-04
NO983945L (no) 1998-10-06
CN1211990A (zh) 1999-03-24
ATE217322T1 (de) 2002-05-15
CA2244219A1 (en) 1997-09-04
NZ331119A (en) 2000-05-26
IS4834A (is) 1998-08-26
SK113498A3 (en) 1999-02-11
PL328734A1 (en) 1999-02-15
SE9600769D0 (sv) 1996-02-28
AU2109097A (en) 1997-09-16
IL125925A0 (en) 1999-04-11
AU722032B2 (en) 2000-07-20
JP2000506138A (ja) 2000-05-23
KR19990087322A (ko) 1999-12-27
EP0914332A1 (en) 1999-05-12
EE9800266A (et) 1999-02-15
US6034097A (en) 2000-03-07
DE69712490D1 (de) 2002-06-13
EP0914332B1 (en) 2002-05-08

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]