BR9710636A - Análogo de somatostatina ciclizada da espinha dorsal, uso do mesmo, composição farmacêutica,e , processo de tratamento de distúrbios endócrinos, neoplasmas ou distúrbios metabólicos. - Google Patents

Análogo de somatostatina ciclizada da espinha dorsal, uso do mesmo, composição farmacêutica,e , processo de tratamento de distúrbios endócrinos, neoplasmas ou distúrbios metabólicos.

Info

Publication number
BR9710636A
BR9710636A BR9710636-4A BR9710636A BR9710636A BR 9710636 A BR9710636 A BR 9710636A BR 9710636 A BR9710636 A BR 9710636A BR 9710636 A BR9710636 A BR 9710636A
Authority
BR
Brazil
Prior art keywords
disorders
neoplasms
treatment
backbone
analog
Prior art date
Application number
BR9710636-4A
Other languages
English (en)
Inventor
Vered Hornik
Alon Seri-Levy
Gary Gellerman
Chaim Gilon
Original Assignee
Peptor Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peptor Ltd filed Critical Peptor Ltd
Publication of BR9710636A publication Critical patent/BR9710636A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
    • G01R31/28—Testing of electronic circuits, e.g. by signal tracer
    • G01R31/317—Testing of digital circuits
    • G01R31/3181—Functional testing
    • G01R31/3185—Reconfiguring for testing, e.g. LSSD, partitioning
    • G01R31/318533—Reconfiguring for testing, e.g. LSSD, partitioning using scanning techniques, e.g. LSSD, Boundary Scan, JTAG
    • G01R31/318541—Scan latches or cell details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

''ANáLOGO DE SOMATOSTATINA CICLIZADA DA ESPINHA DORSAL, USO DO MESMO ,COMPOSIçãO FARMACêUTICA, E, PROCESSO DE TRATAMENTO DE DISTúRBIOS ENDóCRINOS, NEOPLASMAS OU DISTúRBIOS METABóLICAS''. Novos análogos de peptídos são apresentados. Novos análogos de peptídeo são apresentados. Os novos peptídeos são anólogos de somatostina ciclizada a espinha dorsal conformacionalmente constrangida. Processos para sintetização dos análogos da somatostina e para produção de uma coleção de análogos de somastostina são também apresentados. Além disso, composições farmaceuticas incluindo análogos da somatostina, e processos de uso de tais composições no tratamento distúrbios endócrinos, neoplasmas e distúrbios metabólicos são também apresentados.
BR9710636-4A 1996-07-31 1997-07-30 Análogo de somatostatina ciclizada da espinha dorsal, uso do mesmo, composição farmacêutica,e , processo de tratamento de distúrbios endócrinos, neoplasmas ou distúrbios metabólicos. BR9710636A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/690,090 US5770687A (en) 1995-06-07 1996-07-31 Comformationally constrained backbone cyclized somatostatin analogs
PCT/IL1997/000261 WO1998004583A1 (en) 1996-07-31 1997-07-30 Conformationally constrained backbone cyclized somatostatin analogs

Publications (1)

Publication Number Publication Date
BR9710636A true BR9710636A (pt) 2000-01-11

Family

ID=24771043

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9710636-4A BR9710636A (pt) 1996-07-31 1997-07-30 Análogo de somatostatina ciclizada da espinha dorsal, uso do mesmo, composição farmacêutica,e , processo de tratamento de distúrbios endócrinos, neoplasmas ou distúrbios metabólicos.

Country Status (13)

Country Link
US (1) US5770687A (pt)
EP (1) EP0920446B1 (pt)
JP (1) JP4018752B2 (pt)
KR (1) KR100477710B1 (pt)
CN (1) CN1124282C (pt)
AT (1) ATE363911T1 (pt)
AU (1) AU711100B2 (pt)
BR (1) BR9710636A (pt)
CA (1) CA2262778C (pt)
DE (1) DE69737787T2 (pt)
IL (1) IL128084A0 (pt)
NZ (1) NZ334046A (pt)
WO (1) WO1998004583A1 (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117974A (en) * 1991-10-02 2000-09-12 Peptor Limited Libraries of backbone-cyclized peptidomimetics
IL109943A (en) * 1994-06-08 2006-08-01 Develogen Israel Ltd Conformationally constrained backbone cyclized peptide analogs
US6051554A (en) * 1995-06-07 2000-04-18 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
US6841533B1 (en) 1995-12-07 2005-01-11 Peptor Limited Conformationally constrained backbone cyclized interleukin-6 antagonists
US6015895A (en) * 1995-12-22 2000-01-18 University Technologies International Inc. Linker arm for solid support oligonucleotide synthesis and process for production thereof
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
US6602849B1 (en) 1998-06-16 2003-08-05 Societe De Conseils De Recherche Et D'applications Scientifiques, S.A.S. Cyclic somatostatin analogs
RU2242481C2 (ru) * 1998-06-16 2004-12-20 Сосьете Де Консей Де Решерш Э Д'Аппликасьон Сьентифик Сас Аналоги циклического соматостатина
US7135564B1 (en) * 1998-07-02 2006-11-14 University Technologies International Inc. Reusable solid support for oligonucleotide synthesis
AU6382999A (en) * 1998-08-24 2000-03-14 Jeffrey D. White Somatostatin analogs
US6465613B1 (en) 1998-11-19 2002-10-15 Tulane University Hydrophilic somatostatin analogs
US6358491B1 (en) 1999-08-27 2002-03-19 Berlex Laboratories, Inc. Somatostatin analogs
JP2004501061A (ja) * 1999-12-15 2004-01-15 ペプトル・リミテツド 熱ショックタンパク質６０のフラグメントおよびアンタゴニスト
GB0018891D0 (en) 2000-08-01 2000-09-20 Novartis Ag Organic compounds
PL369336A1 (en) 2001-09-21 2005-04-18 The Administrators Of The Tulane Educational Fund Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof
BR0308090A (pt) * 2002-03-01 2006-04-11 Univ Tulane conjugados de agentes citotóxicos ou terapêuticos e peptìdios biologicamente ativos
IL148921A0 (en) * 2002-03-26 2002-09-12 Peptor Ltd Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy
US7304128B2 (en) 2002-06-04 2007-12-04 E.I. Du Pont De Nemours And Company Carbon nanotube binding peptides
IL150384A0 (en) * 2002-06-24 2002-12-01 Peptor Ltd Radiolabelled somatostatin analogs backbone cyclized through metal complexation
US20040121407A1 (en) * 2002-09-06 2004-06-24 Elixir Pharmaceuticals, Inc. Regulation of the growth hormone/IGF-1 axis
JP2006522100A (ja) * 2003-03-10 2006-09-28 バイオジェン アイデック インク 標的化ペプチドに対するチオール媒介性薬物結合
US20070185031A1 (en) * 2003-07-14 2007-08-09 Northwestern University Reducing polyglutamine-based aggregation
WO2005012332A1 (en) 2003-07-31 2005-02-10 Tranzyme Pharma Spatially-defined macrocycles incorporating peptide bond surrogates
GB0318682D0 (en) 2003-08-08 2003-09-10 Novartis Ag Organic compounds
CN100475271C (zh) * 2003-08-20 2009-04-08 加利福尼亚大学董事会 具有抑制生长激素释放活性的促生长素抑制素类似物
WO2005041901A2 (en) * 2003-11-03 2005-05-12 Elixir Pharmaceuticals, Inc. Therapeutics using somatostatin agonists
DE602005018952D1 (de) * 2004-10-19 2010-03-04 Lonza Ag Peptid-cyclisierung auf harz
CN101203527A (zh) * 2005-05-31 2008-06-18 耶路撒冷希伯来大学伊森姆研究发展公司 主链环化的促黑皮质素激素（αMSH）类似物
WO2011024175A1 (en) 2009-08-28 2011-03-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Macrocyclic compounds, compositions comprising them and methods for preventing or treating hiv infection
FR2956115B1 (fr) 2010-02-05 2012-04-06 Isp Investments Inc Nouveaux peptides activateurs de la caspase-14 et compositions les comprenant
EP2604281B1 (en) 2011-12-14 2014-07-30 Centre National de la Recherche Scientifique (CNRS) Clicked somatostatin conjugated analogs for biological applications
EP2807182A1 (en) 2012-01-23 2014-12-03 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Stabilized peptide helices for inhibiting dimerization of chemokine c motif receptor 2 (ccr2)
WO2015087334A1 (en) 2013-12-15 2015-06-18 Yissum Research Develoment Company Of The Hebrew University Of Jerusalem Ltd. Viperistatin-derived peptides and uses thereof
CN109415413A (zh) 2016-06-07 2019-03-01 耶路撒冷希伯来大学伊森姆研究发展有限公司 髓样分化因子88(myd88)的主链环化抑制肽
WO2019058365A1 (en) 2017-09-19 2019-03-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. SOMATOSTATIN PRODUCTS
EP3927737A1 (en) 2019-02-21 2021-12-29 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Par4 derived peptides, analogs and uses thereof
WO2022003673A1 (en) 2020-06-30 2022-01-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Humanin analogs and uses thereof
WO2025141573A1 (en) 2023-12-27 2025-07-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Calreticulin peptidomimetic inhibitors and prodrugs

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4011182A (en) * 1975-03-21 1977-03-08 American Home Products Corporation Cyclic undecapeptide analogs of somatostatin and intermediates
US3988304A (en) * 1975-08-25 1976-10-26 American Home Products Corporation Cyclic dodecapeptide derivatives of somatostatin and intermediates thereof
US4054558A (en) * 1976-05-24 1977-10-18 American Home Products Corporation Cyclic dodecapeptide and intermediates therefor
SU798098A1 (ru) * 1977-12-14 1981-01-23 Ордена Трудового Красного Знамениинститут Органического Синтезаан Латвийской Ccp Циклический аналог брадикинина,обла-дАющий СпОСОбНОСТью СОздАВАТь пРОлОНги-РОВАННый дЕпРЕССОРНый эффЕКТ B эКСпЕРиМЕН-TE ,A ТАКжЕ ВАСКул РНую пРОНи-цАЕМОСТь B эКСпЕРиМЕНТЕ
US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4310518A (en) * 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4360516A (en) * 1981-04-13 1982-11-23 Merck & Co., Inc. Modified D-retro cyclic hexapeptide somatostatin analogs
JPS5852259A (ja) * 1981-09-22 1983-03-28 Shiraimatsu Shinyaku Kk アミノ酸９個で構成された新規ソマトスタチン類似体
ATE14226T1 (de) * 1981-12-24 1985-07-15 Ciba Geigy Ag Cyclische octapeptide und pharmazeutische praeparate davon, sowie verfahren zur herstellung derselben und ihre anwendung.
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4923963A (en) * 1987-09-02 1990-05-08 Nova Technology Limited Partnership Bradykinin antagonist peptides
EP0334244A3 (en) * 1988-03-25 1991-05-29 The Procter & Gamble Company Bradykinin antagonist peptides
AU3534989A (en) * 1988-04-08 1989-11-03 Scripps Clinic And Research Foundation Polypeptides stabilized by covalent hydrogen bond replacements
IE63490B1 (en) * 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action
JP2882679B2 (ja) * 1989-04-26 1999-04-12 ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド 線状ソマトスタチン類似体
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
DE4119544C1 (pt) * 1991-06-13 1992-10-15 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig, De
US5364851A (en) * 1991-06-14 1994-11-15 International Synthecon, Llc Conformationally restricted biologically active peptides, methods for their production and uses thereof
IL99628A (en) * 1991-10-02 2004-07-25 Yissum Res Dev Co Processes for the preparation of cyclic peptides, and pharmaceutical compositions containing them
US6117974A (en) * 1991-10-02 2000-09-12 Peptor Limited Libraries of backbone-cyclized peptidomimetics
US5371070A (en) * 1992-11-09 1994-12-06 The Salk Institute For Biological Studies Bicyclic GnRH antagonists and a method for regulating the secretion of gonadotropins
EP0788370A4 (en) * 1993-07-09 1998-07-08 Smithkline Beecham Corp CYCLIC, PARTIAL RANDOM PEPTIDE LIBRARIES
IL109943A (en) * 1994-06-08 2006-08-01 Develogen Israel Ltd Conformationally constrained backbone cyclized peptide analogs

Also Published As

Publication number Publication date
AU3633197A (en) 1998-02-20
WO1998004583A1 (en) 1998-02-05
EP0920446B1 (en) 2007-06-06
KR20000029654A (ko) 2000-05-25
DE69737787D1 (de) 2007-07-19
NZ334046A (en) 1999-10-28
AU711100B2 (en) 1999-10-07
CN1124282C (zh) 2003-10-15
CN1231672A (zh) 1999-10-13
JP4018752B2 (ja) 2007-12-05
CA2262778A1 (en) 1998-02-05
EP0920446A1 (en) 1999-06-09
KR100477710B1 (ko) 2005-03-18
ATE363911T1 (de) 2007-06-15
IL128084A0 (en) 1999-11-30
DE69737787T2 (de) 2008-03-06
EP0920446A4 (en) 2004-06-02
CA2262778C (en) 2006-10-10
US5770687A (en) 1998-06-23
JP2000516592A (ja) 2000-12-12

Similar Documents

Publication Publication Date Title
IL128084A0 (en) Conformationally constrained backbone cyclized somatostatin analogs
YU19903A (sh) Novi receptor nukleinskih kiselina i polipeptida
IL139956A0 (en) Conformationally constrained backbone cyclized somatostatin analogs
NZ503651A (en) Cyclic amino acids and derivatives thereof useful as pharmaceutical agents
ES2178000T3 (es) Composiciones y metodos para tratar infecciones usando analogos de indolicidina.
BG101132A (en) Pyridoanilated thienyl and furanyl oxazolidinons
ATE427353T1 (de) Heregulin varianten
YU46097A (sh) Nova klasa estara i njihove farmaceutske smeše
PT910647E (pt) Variantes hiperactivas da dnase i humana
IS5386A (is) Prótínblanda og ferli til að einangra prótínblöndu úr vöðvavef
DE69731373D1 (de) Cc-chemokinzeptor c-c ckr-5, dessen derivate und verwendungen
AU6020099A (en) Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
MX9703643A (es) Metodos para tratamiento de esclerosis multiple usando analogos de peptidos de proteina basica de mielina humana.
IL125590A (en) Peptide immunogens, process for their preparation and use thereof as vaccines against allergies
EP0797999A3 (en) Formulations of obesity protein
EP0968156A4 (en) Gas generant compositions, methods of production of the same and devices made therefrom
BR0312889A (pt) Polipeptìdeo t20 peguilado
IT1294967B1 (it) Composizione immunogenica da tlp
EP1174439A3 (en) Compositions and methods for treating infections using analogues of indolicidin
WO2001092468A3 (en) Novel compositions for the expression of the human peptide histidine transporter 1 and methods of use thereof
PL321890A1 (en) Variants human dnase i
AU4956901A (en) Novel human 7tm proteins and polynucleotides encoding the same

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: O DEPOSITANTE DEIXOU DE APRESENTAR MANIFESTACAO SOBRE O PARECER NEGATIVO, ASSIM, DE ACORDO COM O ART. 36 DA LPI (LEI 9279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR.