BR9711363A - Sintese de bis-indolilmaleimidas - Google Patents
Sintese de bis-indolilmaleimidasInfo
- Publication number
- BR9711363A BR9711363A BR9711363A BR9711363A BR9711363A BR 9711363 A BR9711363 A BR 9711363A BR 9711363 A BR9711363 A BR 9711363A BR 9711363 A BR9711363 A BR 9711363A BR 9711363 A BR9711363 A BR 9711363A
- Authority
- BR
- Brazil
- Prior art keywords
- indolylmaleimides
- bis
- synthesis
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000003924 bisindolylmaleimides Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
- C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2412096P | 1996-08-23 | 1996-08-23 | |
| PCT/US1997/014771 WO1998007693A1 (en) | 1996-08-23 | 1997-08-22 | Synthesis of bisindolylmalimides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9711363A true BR9711363A (pt) | 1999-08-17 |
Family
ID=21818966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9711363A BR9711363A (pt) | 1996-08-23 | 1997-08-22 | Sintese de bis-indolilmaleimidas |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5990319A (pt) |
| EP (1) | EP0825190A1 (pt) |
| JP (1) | JP2000516632A (pt) |
| KR (1) | KR20000068323A (pt) |
| CN (1) | CN1228082A (pt) |
| AU (1) | AU716840B2 (pt) |
| BR (1) | BR9711363A (pt) |
| CA (1) | CA2263862A1 (pt) |
| EA (1) | EA001392B1 (pt) |
| HU (1) | HUP0003203A3 (pt) |
| IL (1) | IL128376A0 (pt) |
| NO (1) | NO990832L (pt) |
| NZ (1) | NZ334030A (pt) |
| PL (1) | PL331899A1 (pt) |
| WO (1) | WO1998007693A1 (pt) |
| YU (1) | YU9499A (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR017200A1 (es) | 1997-12-23 | 2001-08-22 | Astrazeneca Ab | Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos |
| SE9800835D0 (sv) | 1998-03-13 | 1998-03-13 | Astra Ab | New Compounds |
| US6492406B1 (en) | 1999-05-21 | 2002-12-10 | Astrazeneca Ab | Pharmaceutically active compounds |
| ATE486872T1 (de) | 2005-02-09 | 2010-11-15 | Arqule Inc | Maleimid-derivate, pharmazeutische zusammensetzungen und verfahren zur behandlung von krebs |
| AU2008268613A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Quinazolinone compounds and methods of use thereof |
| WO2009002806A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer |
| EP2392574B1 (en) | 2007-06-22 | 2013-12-18 | ArQule, Inc. | Indolyl pyrrolidines for the treatment of cancer |
| FR2927075A1 (fr) * | 2008-02-04 | 2009-08-07 | Centre Nat Rech Scient | Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes |
| WO2013162714A1 (en) * | 2012-04-23 | 2013-10-31 | Arqule, Inc. | Highly pure pyrroloquinolinyl-pyrrole-2,5-dione and pyrroloquinolinyl-pyrrolidine-2,5-dione and methods of preparing same |
| CN104496970B (zh) * | 2014-12-17 | 2017-01-11 | 河南师范大学 | 3,4-二(3-吲哚)-2,5-二酮-3-吡咯啉亚胺类化合物及其制备方法和应用 |
| CN104710412B (zh) * | 2015-03-27 | 2017-03-22 | 河南师范大学 | 具有抗癌活性的3,4‑二(3‑吲哚)‑2,5‑二酮‑1‑吡咯胺硫脲类化合物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ280738B6 (cs) * | 1988-02-10 | 1996-04-17 | F. Hoffmann - La Roche And Co., Aktiengesellschaft | Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi |
| GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
| US5339712A (en) * | 1993-10-25 | 1994-08-23 | Daryoush Keyvani | Hand tool having offset work elements |
| US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5541347A (en) * | 1993-12-07 | 1996-07-30 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
| US5559228A (en) * | 1995-03-30 | 1996-09-24 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
-
1997
- 1997-08-22 YU YU9499A patent/YU9499A/sh unknown
- 1997-08-22 HU HU0003203A patent/HUP0003203A3/hu unknown
- 1997-08-22 EP EP97306438A patent/EP0825190A1/en not_active Withdrawn
- 1997-08-22 IL IL12837697A patent/IL128376A0/xx unknown
- 1997-08-22 US US08/917,052 patent/US5990319A/en not_active Expired - Fee Related
- 1997-08-22 PL PL97331899A patent/PL331899A1/xx unknown
- 1997-08-22 CN CN97197361A patent/CN1228082A/zh active Pending
- 1997-08-22 EA EA199900221A patent/EA001392B1/ru not_active IP Right Cessation
- 1997-08-22 CA CA002263862A patent/CA2263862A1/en not_active Abandoned
- 1997-08-22 AU AU41570/97A patent/AU716840B2/en not_active Ceased
- 1997-08-22 KR KR1019997001485A patent/KR20000068323A/ko not_active Withdrawn
- 1997-08-22 NZ NZ334030A patent/NZ334030A/xx unknown
- 1997-08-22 BR BR9711363A patent/BR9711363A/pt unknown
- 1997-08-22 JP JP10510991A patent/JP2000516632A/ja active Pending
- 1997-08-22 WO PCT/US1997/014771 patent/WO1998007693A1/en not_active Ceased
-
1998
- 1998-05-19 US US09/081,252 patent/US5948907A/en not_active Expired - Fee Related
-
1999
- 1999-02-22 NO NO990832A patent/NO990832L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0003203A2 (hu) | 2001-06-28 |
| JP2000516632A (ja) | 2000-12-12 |
| YU9499A (sh) | 2000-03-21 |
| NZ334030A (en) | 2000-08-25 |
| US5948907A (en) | 1999-09-07 |
| WO1998007693A1 (en) | 1998-02-26 |
| CN1228082A (zh) | 1999-09-08 |
| AU4157097A (en) | 1998-03-06 |
| AU716840B2 (en) | 2000-03-09 |
| NO990832D0 (no) | 1999-02-22 |
| CA2263862A1 (en) | 1998-02-26 |
| US5990319A (en) | 1999-11-23 |
| EA199900221A1 (ru) | 1999-08-26 |
| PL331899A1 (en) | 1999-08-16 |
| EP0825190A1 (en) | 1998-02-25 |
| NO990832L (no) | 1999-04-13 |
| IL128376A0 (en) | 2000-01-31 |
| KR20000068323A (ko) | 2000-11-25 |
| EA001392B1 (ru) | 2001-02-26 |
| HUP0003203A3 (en) | 2002-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |