BR9713537A - omo agonistas a alfa-2-adrenorreceptor - Google Patents
omo agonistas a alfa-2-adrenorreceptorInfo
- Publication number
- BR9713537A BR9713537A BR9713537A BR9713537A BR9713537A BR 9713537 A BR9713537 A BR 9713537A BR 9713537 A BR9713537 A BR 9713537A BR 9713537 A BR9713537 A BR 9713537A BR 9713537 A BR9713537 A BR 9713537A
- Authority
- BR
- Brazil
- Prior art keywords
- hydrogen
- unsubstituted
- alpha
- dialkylamino
- alkylamino
- Prior art date
Links
- 102000030484 alpha-2 Adrenergic Receptor Human genes 0.000 title abstract 2
- 108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- -1 amino, hydroxy, mercapto Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Patente de Invenção: <B>"COMPOSTOS DE 2-IMIDAZOLINRENORRECEPTOR"<D>. Esta invenção envolve compostosentre hidrogênio; C~ 1~-C~ 3~ alcanila, alquenila ou alquinila não substituído; cicloalcanila, cicloalquenila; C~ 1~-C~ 3~ alquiltio ou alcóxi não substituído; hidróxi; tio; nitro; ciano; amino; C~ 1~-C~ 3~ alquilamino ou C~ 1~-C~ 3~ dialquilamino e halo; b) R~ 4~ é selecionado entre hidrogênio; C~ 1~-C~ 3~ alcanila não substituído; amino, hidróxi, mercapto; C~ 1~-C~ 3~ alquiltio ou alcóxi; C~ 1~-C~ 3~ alquilamino ou C~ 1~-C~ 3~ dialquilamino e halo; c) R~ 5~ é hidrogênio; ou alquila ou nada; d) quando R~ 5~ for nada, a ligação (a) é uma dupla ligação; e) o grupamento imidazolinilamino está liómeros, isómeros ópticos, estereoisómeros, diaestereoisómeros, tautómeros, sais de adição, amidas e ésteres biohidrolisáveis dos mesmos, assim como composições farmacêuticas que compreendem tais novosto de perturbações moduladas por alfa-2 adrenorreceptores.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3178796P | 1996-11-25 | 1996-11-25 | |
| PCT/US1997/020803 WO1998023611A1 (en) | 1996-11-25 | 1997-11-21 | 2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9713537A true BR9713537A (pt) | 2000-03-21 |
Family
ID=21861392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9713537A BR9713537A (pt) | 1996-11-25 | 1997-11-21 | omo agonistas a alfa-2-adrenorreceptor |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6110952A (pt) |
| EP (1) | EP0944622A1 (pt) |
| JP (1) | JP2001506601A (pt) |
| KR (1) | KR20000069128A (pt) |
| AU (1) | AU736992B2 (pt) |
| BR (1) | BR9713537A (pt) |
| CA (1) | CA2272683A1 (pt) |
| CO (1) | CO4910150A1 (pt) |
| CZ (1) | CZ183699A3 (pt) |
| HU (1) | HUP0002966A3 (pt) |
| ID (1) | ID22060A (pt) |
| IL (1) | IL130094A (pt) |
| NO (1) | NO313755B1 (pt) |
| PE (1) | PE16599A1 (pt) |
| SK (1) | SK74999A3 (pt) |
| TR (1) | TR199901486T2 (pt) |
| WO (1) | WO1998023611A1 (pt) |
| ZA (1) | ZA9710579B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU736992B2 (en) * | 1996-11-25 | 2001-08-09 | Procter & Gamble Company, The | 2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists |
| AU3864000A (en) * | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses |
| EP1815206B1 (en) * | 2004-10-13 | 2016-04-06 | PTC Therapeutics, Inc. | Compounds for nonsense suppression, and methods for their use |
| ZA200804550B (en) | 2005-11-09 | 2009-08-26 | Combinatorx Inc | Methods, compositions, and kits for the treatment of medical conditions |
| US20100202979A1 (en) * | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of pulmonary diseases and conditions |
| US20100197694A1 (en) * | 2008-08-01 | 2010-08-05 | Gerald Horn | Compositions and methods for treatment of diseases and conditions with increased vascular permeability |
| US20110003823A1 (en) * | 2008-08-01 | 2011-01-06 | Alpha Synergy Development, Inc. | Compositions and methods for treatment of diseases and conditions associated with vasodilation and/or vascular leakage |
| US20100203165A1 (en) | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of disorders or conditions of the eye |
| US12246013B2 (en) | 2008-08-01 | 2025-03-11 | Eye Therapies Llc | Vasoconstriction compositions and methods of use |
| US8952011B2 (en) | 2008-08-01 | 2015-02-10 | Eye Therapies Llc | Compositions and methods for the treatment of nasal conditions |
| ES2518418T3 (es) * | 2008-08-01 | 2014-11-05 | Eye Therapies Llc | Composiciones de vasoconstricción y métodos de uso |
| WO2010074753A1 (en) | 2008-12-23 | 2010-07-01 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
| US8987270B2 (en) | 2009-07-27 | 2015-03-24 | Eye Therapies Llc | Formulations of selective alpha-2 agonists and methods of use thereof |
| AU2012287338A1 (en) * | 2011-07-25 | 2014-02-27 | Allergan, Inc. | N-(imidazolidin-2-ylidene)-heterocyclopenta[b]pyridine derivatives as modulators of alpha 2 adrenergic receptors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE795970A (fr) * | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
| US3830804A (en) * | 1972-11-20 | 1974-08-20 | Eastman Kodak Co | Fluorescent(pyrimidinotriazolyl)-2-styrylbenzoxazoles |
| US4398028A (en) * | 1977-01-14 | 1983-08-09 | Sandoz Ltd. | Bicyclic heterocyclic amino derivatives |
| FR2521140A1 (fr) * | 1982-02-05 | 1983-08-12 | Synthelabo | Derives d'imidazolidine, leur preparation et leur application en therapeutique |
| US5091528A (en) * | 1990-09-12 | 1992-02-25 | Allergan, Inc. | 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents |
| GB9110017D0 (en) * | 1991-05-09 | 1991-07-03 | Nat Res Dev | Spectroscopic investigation using organometallic compounds |
| ES2160700T3 (es) * | 1994-01-24 | 2001-11-16 | Allergan Sales Inc | Derivados aromaticos de 2-amino-imidazol como agonistas del adrenorreceptor alfa-2a. |
| AU704972B2 (en) * | 1994-08-04 | 1999-05-13 | H. Lundbeck A/S | Novel benzimidazole derivatives |
| KR100215541B1 (ko) * | 1996-04-19 | 1999-08-16 | 박원훈 | 벤족사졸계 비선형 광학 유도체 및 이들로부터 얻어진고분자 |
| AU736992B2 (en) * | 1996-11-25 | 2001-08-09 | Procter & Gamble Company, The | 2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists |
-
1997
- 1997-11-21 AU AU54382/98A patent/AU736992B2/en not_active Ceased
- 1997-11-21 CZ CZ991836A patent/CZ183699A3/cs unknown
- 1997-11-21 HU HU0002966A patent/HUP0002966A3/hu unknown
- 1997-11-21 US US09/308,792 patent/US6110952A/en not_active Expired - Fee Related
- 1997-11-21 CA CA002272683A patent/CA2272683A1/en not_active Abandoned
- 1997-11-21 TR TR1999/01486T patent/TR199901486T2/xx unknown
- 1997-11-21 JP JP52469598A patent/JP2001506601A/ja active Pending
- 1997-11-21 WO PCT/US1997/020803 patent/WO1998023611A1/en not_active Ceased
- 1997-11-21 KR KR1019997004616A patent/KR20000069128A/ko not_active Ceased
- 1997-11-21 SK SK749-99A patent/SK74999A3/sk unknown
- 1997-11-21 EP EP97948291A patent/EP0944622A1/en not_active Withdrawn
- 1997-11-21 IL IL13009497A patent/IL130094A/en not_active IP Right Cessation
- 1997-11-21 ID IDW990411A patent/ID22060A/id unknown
- 1997-11-21 BR BR9713537A patent/BR9713537A/pt not_active Application Discontinuation
- 1997-11-24 CO CO97068611A patent/CO4910150A1/es unknown
- 1997-11-25 PE PE1997001065A patent/PE16599A1/es not_active Application Discontinuation
- 1997-11-25 ZA ZA9710579A patent/ZA9710579B/xx unknown
-
1999
- 1999-05-25 NO NO19992500A patent/NO313755B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0002966A2 (hu) | 2001-09-28 |
| EP0944622A1 (en) | 1999-09-29 |
| HUP0002966A3 (en) | 2001-10-29 |
| TR199901486T2 (xx) | 1999-10-21 |
| ZA9710579B (en) | 1998-06-25 |
| AU736992B2 (en) | 2001-08-09 |
| KR20000069128A (ko) | 2000-11-25 |
| NO992500D0 (no) | 1999-05-25 |
| CZ183699A3 (cs) | 1999-09-15 |
| IL130094A0 (en) | 2000-02-29 |
| SK74999A3 (en) | 2000-02-14 |
| WO1998023611A1 (en) | 1998-06-04 |
| US6110952A (en) | 2000-08-29 |
| CO4910150A1 (es) | 2000-04-24 |
| ID22060A (id) | 1999-08-26 |
| CA2272683A1 (en) | 1998-06-04 |
| AU5438298A (en) | 1998-06-22 |
| NO992500L (no) | 1999-07-26 |
| IL130094A (en) | 2001-09-13 |
| JP2001506601A (ja) | 2001-05-22 |
| NO313755B1 (no) | 2002-11-25 |
| PE16599A1 (es) | 1999-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A E 6A ANUIDADES. |
|
| B08H | Application fees: decision cancelled [chapter 8.8 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1817 DE 01/11/2005 POR TER SIDO APRESENTADA PAPELETA DE ESCLARECIMENTO. |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE, DE ACORDO COM ART. 36 DA LPI (LEI 9279/96). |