BR9809596A - Compostos de piperidina, isÈmero óptico ou mistura de isÈmeros ópticos, composição farmacêutica, uso de um composto, e, processos para tratamento ou prevenção de doenças do sistema endocrinológico e para tratamento ou prevenção de diabetes não dependente de insulina (niddm ou diabetes tipo 2) e/ou tratamento ou prevenção de complicações a longo prazo - Google Patents
Compostos de piperidina, isÈmero óptico ou mistura de isÈmeros ópticos, composição farmacêutica, uso de um composto, e, processos para tratamento ou prevenção de doenças do sistema endocrinológico e para tratamento ou prevenção de diabetes não dependente de insulina (niddm ou diabetes tipo 2) e/ou tratamento ou prevenção de complicações a longo prazoInfo
- Publication number
- BR9809596A BR9809596A BR9809596-0A BR9809596A BR9809596A BR 9809596 A BR9809596 A BR 9809596A BR 9809596 A BR9809596 A BR 9809596A BR 9809596 A BR9809596 A BR 9809596A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- treating
- prevention
- diabetes
- long
- Prior art date
Links
- 230000002265 prevention Effects 0.000 title abstract 6
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title abstract 5
- 230000003287 optical effect Effects 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000007774 longterm Effects 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 230000002124 endocrine Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010054805 Macroangiopathy Diseases 0.000 abstract 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 1
- 208000017442 Retinal disease Diseases 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 abstract 1
- 201000008980 hyperinsulinism Diseases 0.000 abstract 1
- 235000012054 meals Nutrition 0.000 abstract 1
- 206010062198 microangiopathy Diseases 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"COMPOSTOS DE PIPERIDINA, ISÈMERO óPTICO OU MISTURA DE ISÈMEROS óPTICOS, COMPOSIçãO FARMACêUTICA, USO DE UM COMPOSTO, E, PROCESSOS PARA TRATAMENTO OU PREVENçãO DE DOENçAS DO SISTEMA ENDOCRINOLóGICO E PARA TRATAMENTO OU PREVENçãO DE DIABETES NãO DEPENDENTE DE INSULINA (NIDDM OU DIABETES TIPO 2) E/OU TRATAMENTO OU PREVENçãO DE COMPLICAçõES A LONGO PRAZO" São fornecidos novos compostos de piperidina, e esses compostos são úteis no tratamento e/ou prevenção de diabetes, e especialmente diabetes não dependentes de insulina (NIDDM ou diabetes tipo 2) incluindo tratamento durante a noite ou nas refeições e tratamento ou prevenção de complicações a longo prazo, tais como retinopatia, neuropatia e micro- e macro-angiopatia; tratamento de hiperglicemia, hipercolesterolemia, hipertensão, hiperinsulinemia, hiperlipidemia, aterosclerose ou isquemia miocardial.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK52697 | 1997-05-06 | ||
| PCT/DK1998/000177 WO1998050359A1 (en) | 1997-05-06 | 1998-05-06 | Novel heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9809596A true BR9809596A (pt) | 2000-07-04 |
Family
ID=8094549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9809596-0A BR9809596A (pt) | 1997-05-06 | 1998-05-06 | Compostos de piperidina, isÈmero óptico ou mistura de isÈmeros ópticos, composição farmacêutica, uso de um composto, e, processos para tratamento ou prevenção de doenças do sistema endocrinológico e para tratamento ou prevenção de diabetes não dependente de insulina (niddm ou diabetes tipo 2) e/ou tratamento ou prevenção de complicações a longo prazo |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JP2002515064A (pt) |
| KR (1) | KR20010012299A (pt) |
| CN (1) | CN1306511A (pt) |
| AU (1) | AU741660B2 (pt) |
| BR (1) | BR9809596A (pt) |
| CA (1) | CA2289001A1 (pt) |
| NO (1) | NO995430D0 (pt) |
| PL (1) | PL336639A1 (pt) |
| ZA (1) | ZA983800B (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2096111A1 (en) | 2006-11-20 | 2009-09-02 | Japan Tobacco Inc. | Pyrazoles and use thereof as drugs |
| CN102093260B (zh) * | 2009-12-14 | 2014-03-05 | 太景生物科技股份有限公司 | 哌啶衍生物的立体有择合成 |
-
1998
- 1998-05-06 BR BR9809596-0A patent/BR9809596A/pt not_active IP Right Cessation
- 1998-05-06 CA CA002289001A patent/CA2289001A1/en not_active Abandoned
- 1998-05-06 PL PL98336639A patent/PL336639A1/xx unknown
- 1998-05-06 CN CN98804814A patent/CN1306511A/zh active Pending
- 1998-05-06 KR KR19997010251A patent/KR20010012299A/ko not_active Withdrawn
- 1998-05-06 JP JP54764798A patent/JP2002515064A/ja active Pending
- 1998-05-06 ZA ZA983800A patent/ZA983800B/xx unknown
- 1998-05-06 AU AU72058/98A patent/AU741660B2/en not_active Ceased
-
1999
- 1999-11-05 NO NO995430A patent/NO995430D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO995430L (no) | 1999-11-05 |
| AU741660B2 (en) | 2001-12-06 |
| CA2289001A1 (en) | 1998-11-12 |
| KR20010012299A (ko) | 2001-02-15 |
| CN1306511A (zh) | 2001-08-01 |
| PL336639A1 (en) | 2000-07-03 |
| JP2002515064A (ja) | 2002-05-21 |
| NO995430D0 (no) | 1999-11-05 |
| ZA983800B (en) | 1998-11-06 |
| AU7205898A (en) | 1998-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A, 7A, 8A E 9A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007. |