BR9810186A - Tratamento de diabete com tiazolidinadiona e inibidor de alfa-glicosidade - Google Patents
Tratamento de diabete com tiazolidinadiona e inibidor de alfa-glicosidadeInfo
- Publication number
- BR9810186A BR9810186A BR9810186-2A BR9810186A BR9810186A BR 9810186 A BR9810186 A BR 9810186A BR 9810186 A BR9810186 A BR 9810186A BR 9810186 A BR9810186 A BR 9810186A
- Authority
- BR
- Brazil
- Prior art keywords
- alpha
- inhibitor
- glycosity
- thiazolidinedione
- diabetes treatment
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 4
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 title 1
- 229940123464 Thiazolidinedione Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 239000003888 alpha glucosidase inhibitor Substances 0.000 abstract 1
- 230000002058 anti-hyperglycaemic effect Effects 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Fodder In General (AREA)
Abstract
"TRATAMENTO DE DIABETE COM TIAZOLIDINADIONA E INIBIDOR DE ALFA-GLICOSIDASE" Descreve-se um método para o tratamento de diabete melito e condições associadas a diabete melito em um mamífero, método esse que compreende administrar uma quantidade eficaz, atóxica e farmaceuticamente aceitável de um sensibilizador de insulina, e um agente anti-hiperglicêmico inibidor de alfa-glicosidase, a um mamífero que dela necessite.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9712865.6A GB9712865D0 (en) | 1997-06-18 | 1997-06-18 | Novel method of treatment |
| GBGB9806708.5A GB9806708D0 (en) | 1998-03-27 | 1998-03-27 | Novel method |
| PCT/EP1998/003691 WO1998057635A1 (en) | 1997-06-18 | 1998-06-15 | Treatment of diabetes with thiazolidinedione and alpha-glucosidase inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9810186A true BR9810186A (pt) | 2000-08-08 |
Family
ID=26311746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9810186-2A BR9810186A (pt) | 1997-06-18 | 1998-06-15 | Tratamento de diabete com tiazolidinadiona e inibidor de alfa-glicosidade |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0975343A1 (pt) |
| JP (1) | JP2001523271A (pt) |
| KR (1) | KR20010013845A (pt) |
| CN (1) | CN1274282A (pt) |
| AP (1) | AP9901720A0 (pt) |
| AR (2) | AR014881A1 (pt) |
| AU (1) | AU8799998A (pt) |
| BG (1) | BG103966A (pt) |
| BR (1) | BR9810186A (pt) |
| CA (1) | CA2294134A1 (pt) |
| CO (1) | CO4940453A1 (pt) |
| DZ (1) | DZ2519A1 (pt) |
| EA (1) | EA200000040A1 (pt) |
| IL (1) | IL133138A0 (pt) |
| MA (1) | MA26510A1 (pt) |
| NO (1) | NO996270D0 (pt) |
| NZ (1) | NZ501345A (pt) |
| OA (1) | OA11631A (pt) |
| PE (1) | PE89199A1 (pt) |
| PL (1) | PL337577A1 (pt) |
| SK (1) | SK179499A3 (pt) |
| TR (1) | TR199903072T2 (pt) |
| UY (1) | UY25051A1 (pt) |
| WO (1) | WO1998057635A1 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| DE60004658T2 (de) | 1999-04-23 | 2004-06-24 | Smithkline Beecham Plc, Brentford | Thiazolidindionderivat und seine verwendung als antidiabetikum |
| WO2002080936A1 (en) | 2001-04-04 | 2002-10-17 | Ortho Mcneil Pharmaceutical, Inc. | Combination therapy comprising glucose reabsorption inhibitors and ppar modulators |
| JP4590158B2 (ja) | 2001-04-04 | 2010-12-01 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | グルコース再吸収阻害剤およびレチノイド−ｘ受容体モジュレーターを含んで成る併用療法 |
| FR2832930A1 (fr) * | 2001-12-03 | 2003-06-06 | Lipha | Composition pharmaceutique comprenant un inhibiteur d'alpha-glucosidase et un derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete |
| JP2004067575A (ja) * | 2002-08-06 | 2004-03-04 | Yaizu Suisankagaku Industry Co Ltd | 糖尿病治療薬効果促進剤 |
| CN101121004B (zh) * | 2006-08-08 | 2010-07-21 | 鲁南制药集团股份有限公司 | 含有胰岛素增敏剂和米格列醇的药物组合物 |
| CN101584688B (zh) * | 2008-05-24 | 2010-11-10 | 鲁南制药集团股份有限公司 | 一种治疗糖尿病及其并发症的药物组合物 |
| CN101584705B (zh) * | 2008-05-24 | 2010-10-27 | 鲁南制药集团股份有限公司 | 一种治疗糖尿病及其并发症的药物组合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5900435A (en) * | 1991-08-26 | 1999-05-04 | Pharmacia & Upjohn Company | Composition, food product and uses of 3-guanidinopropionic acid |
| US5917052A (en) * | 1994-09-28 | 1999-06-29 | Shaman Pharmaceuticals, Inc. | Hypoglycemic agent from cryptolepis |
| TWI238064B (en) * | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
-
1998
- 1998-06-15 AU AU87999/98A patent/AU8799998A/en not_active Abandoned
- 1998-06-15 IL IL13313898A patent/IL133138A0/xx unknown
- 1998-06-15 CN CN98806319A patent/CN1274282A/zh active Pending
- 1998-06-15 EP EP98939513A patent/EP0975343A1/en not_active Withdrawn
- 1998-06-15 KR KR1019997011866A patent/KR20010013845A/ko not_active Withdrawn
- 1998-06-15 EA EA200000040A patent/EA200000040A1/ru unknown
- 1998-06-15 BR BR9810186-2A patent/BR9810186A/pt not_active IP Right Cessation
- 1998-06-15 CA CA002294134A patent/CA2294134A1/en not_active Abandoned
- 1998-06-15 WO PCT/EP1998/003691 patent/WO1998057635A1/en not_active Ceased
- 1998-06-15 SK SK1794-99A patent/SK179499A3/sk unknown
- 1998-06-15 AP APAP/P/1999/001720A patent/AP9901720A0/en unknown
- 1998-06-15 PL PL98337577A patent/PL337577A1/xx unknown
- 1998-06-15 TR TR1999/03072T patent/TR199903072T2/xx unknown
- 1998-06-15 JP JP50375699A patent/JP2001523271A/ja not_active Ceased
- 1998-06-17 AR ARP980102885A patent/AR014881A1/es unknown
- 1998-06-17 AR ARP980102882A patent/AR013352A1/es unknown
- 1998-06-17 DZ DZ980129A patent/DZ2519A1/xx active
- 1998-06-17 MA MA25121A patent/MA26510A1/fr unknown
- 1998-06-18 UY UY25051A patent/UY25051A1/es not_active Application Discontinuation
- 1998-06-18 PE PE1998000536A patent/PE89199A1/es not_active Application Discontinuation
- 1998-06-18 CO CO98034648A patent/CO4940453A1/es unknown
- 1998-07-15 NZ NZ501345A patent/NZ501345A/en unknown
-
1999
- 1999-12-08 BG BG103966A patent/BG103966A/bg unknown
- 1999-12-17 NO NO996270A patent/NO996270D0/no not_active Application Discontinuation
- 1999-12-17 OA OA9900295A patent/OA11631A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR014881A1 (es) | 2001-04-11 |
| AU8799998A (en) | 1999-01-04 |
| EP0975343A1 (en) | 2000-02-02 |
| NO996270L (no) | 1999-12-17 |
| OA11631A (en) | 2004-11-22 |
| SK179499A3 (en) | 2000-11-07 |
| PL337577A1 (en) | 2000-08-28 |
| NO996270D0 (no) | 1999-12-17 |
| AP9901720A0 (en) | 1999-12-31 |
| DZ2519A1 (fr) | 2003-02-01 |
| CN1274282A (zh) | 2000-11-22 |
| UY25051A1 (es) | 2000-09-29 |
| AR013352A1 (es) | 2000-12-27 |
| JP2001523271A (ja) | 2001-11-20 |
| EA200000040A1 (ru) | 2000-08-28 |
| CO4940453A1 (es) | 2000-07-24 |
| MA26510A1 (fr) | 2004-12-20 |
| IL133138A0 (en) | 2001-03-19 |
| CA2294134A1 (en) | 1998-12-23 |
| TR199903072T2 (xx) | 2000-07-21 |
| NZ501345A (en) | 2001-10-26 |
| PE89199A1 (es) | 1999-10-23 |
| KR20010013845A (ko) | 2001-02-26 |
| BG103966A (bg) | 2000-07-31 |
| WO1998057635A1 (en) | 1998-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A,7A,8A E 9AANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007. |