BR9810568A - Composição, uso da mesma, e, processo para extrair uma imuno resposta para um antìgeno em um mamìfero, para fornecer um antìgeno para uma superfìcie mucósica de um mamìfero e para fornecer um agente bioativo para um vegetal - Google Patents

Composição, uso da mesma, e, processo para extrair uma imuno resposta para um antìgeno em um mamìfero, para fornecer um antìgeno para uma superfìcie mucósica de um mamìfero e para fornecer um agente bioativo para um vegetal

Info

Publication number
BR9810568A
BR9810568A BR9810568-0A BR9810568A BR9810568A BR 9810568 A BR9810568 A BR 9810568A BR 9810568 A BR9810568 A BR 9810568A BR 9810568 A BR9810568 A BR 9810568A
Authority
BR
Brazil
Prior art keywords
antigen
mammal
adjuvant
immune response
extract
Prior art date
Application number
BR9810568-0A
Other languages
English (en)
Inventor
Sveinbjoern Gizurarson
Vera Gudmundsdottir
Original Assignee
Lyfjathroun Hf The Icelandic B
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lyfjathroun Hf The Icelandic B filed Critical Lyfjathroun Hf The Icelandic B
Publication of BR9810568A publication Critical patent/BR9810568A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cultivation Of Plants (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"COMPOSIçãO, USO DA MESMA, E, PROCESSOS PARA EXTRAIR UMA IMUNO RESPOSTA PARA UM ANTìGENO EM UM MAMìFERO, PARA FORNECER UM ANTìGENO PARA UMA SUPERFìCIE MUCóSICA DE UM MAMìFERO E PARA FORNECER UM AGENTE BIOATIVO PARA UM VEGETAL". Os adjuvantes para a administração, particularmente para a administração mucósica de um antígeno estão descritas, bem como composições que compreendam o adjuvante descrito em combinações com um antígeno e um veículo fisiologicamente aceitável. Os processos de extrair e intensificar uma resposta imuno utilizando-se das composições adjuvantes da invenção também estão descritas. O adjuvante compreende mono ou diglicerídeos que contenham pelo menos um polímero solúvel em água, por exemplo o poli oxietileno (PEG~ 2-30~). O antígeno pode estar ligado ao adjuvante. O adjuvante pode ser usado também no tratamento de vegetais.
BR9810568-0A 1997-07-09 1998-07-09 Composição, uso da mesma, e, processo para extrair uma imuno resposta para um antìgeno em um mamìfero, para fornecer um antìgeno para uma superfìcie mucósica de um mamìfero e para fornecer um agente bioativo para um vegetal BR9810568A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IS4518A IS4518A (is) 1997-07-09 1997-07-09 Nýtt lyfjaform fyrir bóluefni
PCT/IS1998/000006 WO1999002186A2 (en) 1997-07-09 1998-07-09 Antigen delivery system comprising monoglyceride or diglyceride derivatives as adjuvant

Publications (1)

Publication Number Publication Date
BR9810568A true BR9810568A (pt) 2000-09-19

Family

ID=36699745

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9810568-0A BR9810568A (pt) 1997-07-09 1998-07-09 Composição, uso da mesma, e, processo para extrair uma imuno resposta para um antìgeno em um mamìfero, para fornecer um antìgeno para uma superfìcie mucósica de um mamìfero e para fornecer um agente bioativo para um vegetal

Country Status (13)

Country Link
US (2) US6514503B1 (pt)
EP (1) EP1003551B1 (pt)
JP (1) JP2001509491A (pt)
KR (1) KR20010021622A (pt)
CN (1) CN1202863C (pt)
AT (1) ATE329617T1 (pt)
AU (1) AU745849B2 (pt)
BR (1) BR9810568A (pt)
CA (1) CA2295237A1 (pt)
DE (1) DE69834921T2 (pt)
ES (1) ES2267189T3 (pt)
IS (2) IS4518A (pt)
WO (1) WO1999002186A2 (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IS4518A (is) * 1997-07-09 1999-01-10 Lyfjathroun Hf, The Icelandic Bio Pharmaceutical Group Nýtt lyfjaform fyrir bóluefni
NZ508013A (en) * 1998-05-07 2003-08-29 Corixa Corp Adjuvant composition for use with an antigen in a vaccine composition
NZ515322A (en) * 1999-05-13 2004-03-26 Wyeth Corp Adjuvant combination formulations
EP1212086B8 (en) * 1999-08-18 2008-01-02 Industry-Academic Cooperation Foundation, The Catholic University of Korea Immunological tolerance-induction agent
US7384640B1 (en) * 1999-09-30 2008-06-10 Wyeth Holdings Corporation Mutant cholera holotoxin as an adjuvant
GB0007465D0 (en) 2000-03-29 2000-05-17 Amersham Pharm Biotech Uk Ltd Substrate for a lipase enzyme assay
AU2001270031B2 (en) * 2000-06-22 2005-11-03 Wyeth Holdings Corporation QS-21 and IL-12 as an adjuvant combination
IL155690A0 (en) * 2000-11-10 2003-11-23 Wyeth Corp Adjuvant combination formulations
US7332174B2 (en) 2001-06-07 2008-02-19 Wyeth Holdings Corporation Mutant forms of cholera holotoxin as an adjuvant
AU2002346249B2 (en) 2001-06-07 2007-03-15 The Regents Of The University Of Colorado Mutant Forms of Cholera Holotoxin as an Adjuvant
EP1423430A1 (en) * 2001-08-16 2004-06-02 Lyfjathroun H.F., Biopharmaceuticals A method of producing antibodies ex-vivo
AU2002362039B2 (en) * 2001-12-03 2007-07-26 Soligenix, Inc Stabilized reverse micelle compositions and uses thereof
US20050063940A1 (en) * 2002-02-25 2005-03-24 Sveinbjorn Gizurarson Bioadhesive agent
WO2003070272A1 (en) * 2002-02-25 2003-08-28 Lyfjathroun Hf, Biopharmaceutical Research An immunological adjuvant
US6855332B2 (en) * 2002-07-03 2005-02-15 Lyfjathroun Hf. Absorption promoting agent
EP1566621A4 (en) * 2002-11-21 2010-04-07 Sapporo Immuno Diagnostic Lab INSTRUMENT FOR COLLECTING AND RECOVERING STORAGE
BR0316685A (pt) * 2002-12-17 2005-11-01 Nastech Pharm Co Composições e métodos para a administração aperfeiçoada por via mucosal de peptìdeos fixadores ao receptor de y2 e métodos para tratar e prevenir a obesidade
US8685718B2 (en) * 2003-05-20 2014-04-01 New York University Mucosal immunization to prevent prion infection
WO2005019412A2 (en) 2003-05-20 2005-03-03 New York University Mucosal immunization to prevent prion infection
US20060264505A1 (en) * 2003-11-07 2006-11-23 Stiefel Laboratories, Inc. Dermatological compositions
US20050100621A1 (en) * 2003-11-07 2005-05-12 Popp Karl F. Dermatological compositions
JP2007512006A (ja) * 2003-11-10 2007-05-17 ザ ユーエービー リサーチ ファウンデーション 細菌輸送およびｃｎｓ侵襲を低減させるための組成物およびこの組成物を使用する方法
DE602006020738D1 (de) 2005-08-01 2011-04-28 Hisamitsu Pharmaceutical Co Adjuvans oder pharmazeutische zubereitung zur transdermalen oder transmukosalen verabreichung
WO2008022299A1 (en) * 2006-08-17 2008-02-21 The Uab Research Foundation Diagnosing pneumococcal pneumonia
WO2008093772A1 (ja) * 2007-01-31 2008-08-07 Hisamitsu Pharmaceutical Co., Inc. 経皮または経粘膜投与のためのアジュバントおよびこれを含む医薬製剤
CN101688194B (zh) 2007-05-23 2013-09-11 Uab研究基金会 去毒的肺炎球菌神经氨酸酶及其用途
CA2737684A1 (en) * 2008-10-08 2010-04-15 Immune Solutions Limited Oral vaccines for producing mucosal immunity
EP2405759B1 (en) * 2009-03-11 2018-12-26 Monsanto Technology LLC Herbicidal formulations comprising glyphosate and alkoxylated glycerides
WO2010114169A1 (en) * 2009-03-31 2010-10-07 Japan As Represented By The Director-General Of National Institute Of Infectious Diseases Method for prophylaxis of influenza using vaccine for intranasal administration
AU2011230619C1 (en) 2010-03-25 2016-06-23 Oregon Health & Science University CMV glycoproteins and recombinant vectors
HUE037408T2 (hu) 2011-06-10 2018-08-28 Univ Oregon Health & Science CMV glikoproteinek és rekombináns vektorok
CA2789539A1 (en) 2011-09-12 2013-03-12 International Aids Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
ES2631608T3 (es) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Variante de la glicoproteína Env del VIH-1
EP2848937A1 (en) 2013-09-05 2015-03-18 International Aids Vaccine Initiative Methods of identifying novel HIV-1 immunogens
US10058604B2 (en) 2013-10-07 2018-08-28 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
ES2744454T3 (es) 2013-10-31 2020-02-25 Hisamitsu Pharmaceutical Co Composición de adyuvante
EP3069730A3 (en) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
US9931394B2 (en) 2015-03-23 2018-04-03 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
CU24534B1 (es) * 2017-11-06 2021-07-02 Ct Inmunologia Molecular Adyuvantes nano-particulados que contienen variantes sintéticas del gangliósido gm3

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL195510A (pt) 1955-03-11
FR2253499B1 (pt) 1973-12-10 1977-11-04 Fabre Sa Pierre
US4420484A (en) * 1979-08-13 1983-12-13 Sterling Drug Inc. Basic amino or ammonium antimicrobial agent-polyethylene glycol ester surfactant-betaine and/or amine oxide surfactant compositions and method of use therof
DE3225706C2 (de) 1982-07-09 1984-04-26 A. Nattermann & Cie GmbH, 5000 Köln Flüssige Wirkstofformulierungen in Form von Konzentraten für Mikroemulsionen
JPS60149510A (ja) * 1984-01-13 1985-08-07 Kao Corp 農薬組成物
US4610868A (en) 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
US4771571A (en) 1986-12-31 1988-09-20 Nabisco Brands, Inc. Method for treating pineapple to prevent pineapple fruit diseases
US4911928A (en) 1987-03-13 1990-03-27 Micro-Pak, Inc. Paucilamellar lipid vesicles
EP0324455A3 (en) * 1988-01-15 1991-03-27 Hans O. Ribi Novel polymeric immunological adjuvants
US5190748A (en) * 1988-11-22 1993-03-02 Hoffmann-La Roche Inc. Absorption enhancement of antibiotics
US5177091A (en) * 1990-12-06 1993-01-05 Ciba-Geigy Corporation Use of carbazones as novel active ingredients in medicaments
ATE240740T1 (de) * 1991-03-15 2003-06-15 Amgen Inc Pegylation von polypeptiden
AU668509B2 (en) 1991-04-19 1996-05-09 Affinity Biotech, Inc. Convertible microemulsion formulations
CA2083553A1 (en) 1991-11-25 1993-05-26 Kuniharu Seki Immunogen composition
GB9207799D0 (en) 1992-04-09 1992-05-27 Procter & Gamble Aqueous compositions
US5314685A (en) * 1992-05-11 1994-05-24 Agouron Pharmaceuticals, Inc. Anhydrous formulations for administering lipophilic agents
ATE196254T1 (de) 1992-10-16 2000-09-15 Ibah Inc Konvertierbare mikroemulsionsformulierungen
IT1255895B (it) * 1992-10-20 1995-11-17 Laura Chiodini Composizioni farmaceutiche contenenti una calcitonina
WO1994016061A1 (en) * 1993-01-15 1994-07-21 Micro Vesicular Systems, Inc. Method of inhibiting viral reproduction
DK17093D0 (da) * 1993-02-15 1993-02-15 Lyfjathroun H F Farmaceutisk praeparat til topisk administrering af antigener og/eller vacciner til pattedyr via slimhinder
US5359030A (en) * 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
JP3901213B2 (ja) * 1994-08-05 2007-04-04 インファルマ・ソシエテ・アノニム ホスファチジルコリンとプロスタグランジンｅ１及び／又はトロキサールチンとの複合体を含有する、勃起不能の局所治療のための製剤
FR2729307B1 (fr) 1995-01-18 1997-04-18 Seppic Sa Utilisation d'esters d'acides gras ethoxyles comme composants auto-emulsionnables notamment utiles pour la preparation de produits de traitement phytosanitaires ou de medicaments a usage veterinaire ou humain
US5744137A (en) 1995-02-06 1998-04-28 The United States Of America As Represented By The Secretary Of The Agriculture Oil emulsion vaccines prepared with animal, vegetable, and synthetic oils using a mixture of nonionic surfactants
US6008228A (en) * 1995-06-06 1999-12-28 Hoffman-La Roche Inc. Pharmaceutical compositions containing proteinase inhibitors
CA2223768A1 (en) * 1995-06-09 1996-12-27 R.P. Scherer Corporation Suspension and soft gelatin capsules containing particulate matter
ATE353225T1 (de) * 1995-11-30 2007-02-15 Chemo Sero Therapeut Res Inst Öladjuvierter impfstoff und verfahren zu seiner herstellung
SE9602280D0 (sv) * 1996-06-10 1996-06-10 Pharmatrix Ab Immunstimulerande lipidformulering
AU3868997A (en) * 1996-08-26 1998-03-19 Takeda Chemical Industries Ltd. Pharmaceutical composition containing osteogenesis-promoting substance and a polyethylene glycol
IS4518A (is) * 1997-07-09 1999-01-10 Lyfjathroun Hf, The Icelandic Bio Pharmaceutical Group Nýtt lyfjaform fyrir bóluefni
FR2773489B1 (fr) * 1998-01-15 2001-03-23 Immunotech Sa Nouvelle composition destinee a la voie oromuqueuse notamment pernasale
US6294192B1 (en) * 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
EP1034792A1 (en) * 1999-03-11 2000-09-13 Pasteur Merieux Serums Et Vaccins Intranasal delivery of pneumococcal polysaccharide vaccines
US6458383B2 (en) * 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US6468559B1 (en) * 2000-04-28 2002-10-22 Lipocine, Inc. Enteric coated formulation of bishosphonic acid compounds and associated therapeutic methods
US6495596B1 (en) * 2001-03-23 2002-12-17 Biozibe Laboratories, Inc. Compounds and methods for inhibition of phospholipase A2 and cyclooxygenase-2
US6855332B2 (en) * 2002-07-03 2005-02-15 Lyfjathroun Hf. Absorption promoting agent

Also Published As

Publication number Publication date
US6514503B1 (en) 2003-02-04
EP1003551B1 (en) 2006-06-14
US20030099659A1 (en) 2003-05-29
AU745849B2 (en) 2002-04-11
IS5329A (is) 1999-12-29
JP2001509491A (ja) 2001-07-24
CN1202863C (zh) 2005-05-25
AU8459898A (en) 1999-02-08
ATE329617T1 (de) 2006-07-15
KR20010021622A (ko) 2001-03-15
DE69834921T2 (de) 2007-01-18
EP1003551A2 (en) 2000-05-31
CN1262626A (zh) 2000-08-09
DE69834921D1 (de) 2006-07-27
CA2295237A1 (en) 1999-01-21
ES2267189T3 (es) 2007-03-01
WO1999002186A3 (en) 1999-04-01
IS4518A (is) 1999-01-10
WO1999002186A2 (en) 1999-01-21

Similar Documents

Publication Publication Date Title
BR9810568A (pt) Composição, uso da mesma, e, processo para extrair uma imuno resposta para um antìgeno em um mamìfero, para fornecer um antìgeno para uma superfìcie mucósica de um mamìfero e para fornecer um agente bioativo para um vegetal
PT1187629E (pt) Composicao adjuvante que compreende saponina e um oligonucleotido imunoestimulador
CO5160320A1 (es) Metodos y composiciones para la prevencion de tolerancia a medicamentos das.
DK0957935T3 (da) Chlamydia-vacciner og immunogene præparater indeholdende et ydre membran-antigen samt fremgangsmåde til fremstilling deraf
ES2029758A6 (es) Proacedimiento para la fabricacion de una matriz con actividad inmunomodulora a partir de saponinas.
AR001618A1 (es) Adyuvante de saponina del arbol quillajay y formulacion de vacuna que contiene el mismo
ES2176232T3 (es) Vacuna adecuada para ser utilizada en la prevencion y tratamiento de la infeccion por helicobacter.
ECSP045496A (es) "preparaciones acidas de insulina con estabilidad mejorada"
BRPI9809791B8 (pt) compostos imuno efetores de fosfato de aminoalquil glucosamina e composições compreendendo os mesmos
BR9913751A (pt) Uso de uma composição para proteção do tecido, e, método de tratar tecido para aperfeiçoar a sua estabilidade dimensional
BRPI0407101A (pt) Vacinas meningocócicas mucosais
DE3852761D1 (de) Saponin-hilfsmittel.
CO4410203A1 (es) Formulaciones de analogos de insulina
FI953442A0 (fi) Gonadotropiinia sisältäviä pakastekuivattuja pallosia
BR9813811A (pt) "composições farmacêuticas compreendendo micelas que compreendem glicocorticosteróide lipofìlico e apenas um único tensoativo"
ES2055270T3 (es) Uso de l-azucares para la fabricacion de composiciones laxantes.
ES2156107T3 (es) Un fgf-4 no glicosilado y composiciones que lo contienen.
ES2157886T3 (es) Composiciones tensioactivas y procedimientos.
BR9610679A (pt) Antígenos de leishmania para uso na terapia e disgnose da leishmaniose
DK1150713T3 (da) Vaccineformulering der omfatter monoglycerider eller fedtsyrer som adjuvans
FI935051A0 (fi) Lanolinderivat som penetrationfraemjande aemnen och anvaendning av dessa i preparat innehaollande laekemedel eller andra biologiskt aktiva substanser
AR006345A1 (es) Una composicion farmaceutica para administracion oral que comprende un inhibidor de proteasa del vih y un derivado de tocoferol soluble en agua, y un metodo para preparar dicha composicion.
ES2032280T3 (es) Saponinas de triterpeno que poseen actividad antiinflamatoria, mucolitica y antiedemica, proceso para su preparacion y composiciones farmaceuticas que las contienen.
BR9710849A (pt) Vacina contendo uma peróxi-redoxina e/ou uma beta-tubulina.
PT1047422E (pt) Utilizacao de histamina para elevar os niveis de histamina no sangue

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ART. 36 DA LPI (LEI 9279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR. PORTANTO, INDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO - DE ACORDO COM O ART. 8O DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.