BR9909018A - Processo para a sìntese de um peptìdeo, conjunto de fragmentos de peptìdeo, e, peptìdeo - Google Patents
Processo para a sìntese de um peptìdeo, conjunto de fragmentos de peptìdeo, e, peptìdeoInfo
- Publication number
- BR9909018A BR9909018A BR9909018-0A BR9909018A BR9909018A BR 9909018 A BR9909018 A BR 9909018A BR 9909018 A BR9909018 A BR 9909018A BR 9909018 A BR9909018 A BR 9909018A
- Authority
- BR
- Brazil
- Prior art keywords
- peptide
- peptides
- synthesis
- fragments
- present
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 238000003786 synthesis reaction Methods 0.000 title abstract 4
- 108010033276 Peptide Fragments Proteins 0.000 title abstract 3
- 102000007079 Peptide Fragments Human genes 0.000 title abstract 3
- -1 and Proteins 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 239000000543 intermediate Substances 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 1
- 239000007791 liquid phase Substances 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"PROCESSO PARA A SìNTESE DE UM PEPTìDEO, CONJUNTO DE FRAGMENTOS DE PEPTìDEO,E,PEPTìDEO". A presente invenção refere-se, primeiro, aos processos de síntese de peptídeos, em particular de T-20 (também referido como "DP178"; SEQ ID NO: 1) e de peptídeos semelhantes a T-20. Tais processos utilizam procedimentos de síntese em fases liquida e sólida e combinam grupos de fragmentos de peptídeo específicos para dar o peptídeo de interesse. A presente invenção refere-se em adição aos fragmentos de peptídeo individuais que atuam como intermediários na síntese de peptídeos de interesse (por exemplo, T-20). A presente invenção ainda refere-se adicionalmente aos grupos de tais fragmentos de intermediário de peptídeo que podem ser empregados juntos para produzir T-20 de comprimento total e peptídeos semelhantes a T-20.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/045,920 US6281331B1 (en) | 1998-03-23 | 1998-03-23 | Methods and compositions for peptide synthesis |
| US09/071,877 US6015881A (en) | 1998-03-23 | 1998-05-01 | Methods and compositions for peptide synthesis |
| PCT/US1999/006230 WO1999048513A1 (en) | 1998-03-23 | 1999-03-22 | Methods and compositions for peptide synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9909018A true BR9909018A (pt) | 2001-10-16 |
Family
ID=26723345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9909018-0A BR9909018A (pt) | 1998-03-23 | 1999-03-22 | Processo para a sìntese de um peptìdeo, conjunto de fragmentos de peptìdeo, e, peptìdeo |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1071442B9 (pt) |
| JP (1) | JP4602547B2 (pt) |
| CN (1) | CN100383158C (pt) |
| AT (1) | ATE299029T1 (pt) |
| AU (1) | AU751358B2 (pt) |
| BR (1) | BR9909018A (pt) |
| CA (1) | CA2324348C (pt) |
| DE (1) | DE69926061T2 (pt) |
| DK (1) | DK1071442T3 (pt) |
| ES (1) | ES2245505T3 (pt) |
| NZ (1) | NZ507083A (pt) |
| TW (1) | TWI233931B (pt) |
| WO (1) | WO1999048513A1 (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6281331B1 (en) * | 1998-03-23 | 2001-08-28 | Trimeris, Inc. | Methods and compositions for peptide synthesis |
| US6469136B1 (en) | 1999-07-07 | 2002-10-22 | Trimeris, Inc. | Methods and composition for peptide synthesis |
| CN1255548C (zh) | 2001-06-15 | 2006-05-10 | 霍夫曼-拉罗奇有限公司 | gp41片段的乙酰化 |
| BR0312889A (pt) * | 2002-07-24 | 2005-06-14 | Hoffmann La Roche | Polipeptìdeo t20 peguilado |
| EP1701976A2 (en) * | 2003-12-31 | 2006-09-20 | F.Hoffmann-La Roche Ag | Peptide synthesis and deprotection with co-solvent |
| ATE410437T1 (de) | 2003-12-31 | 2008-10-15 | Hoffmann La Roche | Verfahren und systeme zur rückgewinnung von peptiden |
| WO2005063791A2 (en) | 2003-12-31 | 2005-07-14 | F. Hoffmann-La Roche Ag | Process for peptide synthesis using a reduced amount of deprotection agent |
| JP4886702B2 (ja) * | 2004-12-30 | 2012-02-29 | エフ．ホフマン−ラ ロシュ アーゲー | ペプチド中間体断片を使用するペプチドｔ−２０の合成 |
| EP2013223A2 (en) | 2006-05-03 | 2009-01-14 | Mallinckrodt Inc. | Composition and method for the release of protected peptides from a resin |
| WO2009014177A1 (ja) * | 2007-07-25 | 2009-01-29 | Ajinomoto Co., Inc. | ジベンゾフルベン誘導体の淘汰方法 |
| JP5473925B2 (ja) * | 2007-10-27 | 2014-04-16 | コーデン ファーマ コロラド インコーポレイテッド | 固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成 |
| CA2707132A1 (en) * | 2007-12-11 | 2009-06-18 | F. Hoffmann-La Roche Ag | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
| WO2010016551A1 (ja) * | 2008-08-06 | 2010-02-11 | 味の素株式会社 | ジベンゾフルベンの除去方法 |
| US20110288235A1 (en) * | 2008-09-03 | 2011-11-24 | Scinopharm Taiwan Ltd. | Process for the Preparation of Pramlintide |
| US20100081788A1 (en) * | 2008-09-03 | 2010-04-01 | Scinopharm Taiwan Ltd. | Process for the Preparation of Pramlintide |
| WO2011095989A2 (en) * | 2010-02-04 | 2011-08-11 | Matrix Laboratories Ltd | An improved process for the preparation of enfuvirtide |
| PL219569B1 (pl) * | 2010-02-19 | 2015-05-29 | Peptaderm Spółka Z Ograniczoną Odpowiedzialnością | Cykliczne tetrapeptydy i ich zastosowanie |
| CN103374054B (zh) * | 2012-04-28 | 2014-12-24 | 上海第一生化药业有限公司 | 一步法固相合成多肽的方法 |
| GB201315335D0 (en) | 2013-08-29 | 2013-10-09 | Of Singapore | Amino diacids containing peptide modifiers |
| IL295109A (en) * | 2020-02-05 | 2022-09-01 | Lilly Co Eli | Resin miners in a serial peptide synthesizer |
| CN114315957B (zh) * | 2021-12-30 | 2023-07-07 | 深圳瑞德林生物技术有限公司 | 一种多肽的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU617088B2 (en) * | 1986-06-12 | 1991-11-21 | Biogen, Inc. | Peptides involved in the pathogenesis of hiv infection |
| US4787222A (en) * | 1986-11-24 | 1988-11-29 | Novatek Medical Inc. | Combination lock for blood identification system |
| US5444044A (en) * | 1992-03-26 | 1995-08-22 | New York Blood Center | Synthetic polypeptides as inhibitors of HIV-1 |
| US6479055B1 (en) * | 1993-06-07 | 2002-11-12 | Trimeris, Inc. | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
| US5464933A (en) * | 1993-06-07 | 1995-11-07 | Duke University | Synthetic peptide inhibitors of HIV transmission |
| WO1994028929A1 (en) * | 1993-06-07 | 1994-12-22 | Genentech, Inc. | Hiv envelope polypeptides |
| BR9407531A (pt) * | 1993-09-11 | 1997-08-26 | Polymun Scient Immunbio Forsch | Peptideos que provocam a formação de anticorpos neutralizadores contra cepas de HIV-1 geneticamente divergentes |
| BR9707409A (pt) * | 1996-02-09 | 1999-04-13 | Waleed Danho | Sintese de análogo de vip |
-
1999
- 1999-03-22 NZ NZ507083A patent/NZ507083A/en not_active IP Right Cessation
- 1999-03-22 CN CNB998064319A patent/CN100383158C/zh not_active Expired - Fee Related
- 1999-03-22 JP JP2000537561A patent/JP4602547B2/ja not_active Expired - Fee Related
- 1999-03-22 WO PCT/US1999/006230 patent/WO1999048513A1/en not_active Ceased
- 1999-03-22 DE DE69926061T patent/DE69926061T2/de not_active Expired - Lifetime
- 1999-03-22 ES ES99912802T patent/ES2245505T3/es not_active Expired - Lifetime
- 1999-03-22 CA CA002324348A patent/CA2324348C/en not_active Expired - Lifetime
- 1999-03-22 AT AT99912802T patent/ATE299029T1/de active
- 1999-03-22 DK DK99912802T patent/DK1071442T3/da active
- 1999-03-22 BR BR9909018-0A patent/BR9909018A/pt not_active IP Right Cessation
- 1999-03-22 AU AU31097/99A patent/AU751358B2/en not_active Expired
- 1999-03-22 EP EP99912802A patent/EP1071442B9/en not_active Expired - Lifetime
- 1999-03-23 TW TW088104562A patent/TWI233931B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE299029T1 (de) | 2005-07-15 |
| CN1303299A (zh) | 2001-07-11 |
| AU751358B2 (en) | 2002-08-15 |
| CA2324348A1 (en) | 1999-09-30 |
| CA2324348C (en) | 2006-03-14 |
| EP1071442B1 (en) | 2005-07-06 |
| DE69926061T2 (de) | 2006-06-01 |
| AU3109799A (en) | 1999-10-18 |
| EP1071442A4 (en) | 2002-06-05 |
| EP1071442A1 (en) | 2001-01-31 |
| TWI233931B (en) | 2005-06-11 |
| JP4602547B2 (ja) | 2010-12-22 |
| DE69926061D1 (de) | 2005-08-11 |
| DK1071442T3 (da) | 2005-10-24 |
| CN100383158C (zh) | 2008-04-23 |
| ES2245505T3 (es) | 2006-01-01 |
| EP1071442B9 (en) | 2006-01-18 |
| WO1999048513A1 (en) | 1999-09-30 |
| JP2002507576A (ja) | 2002-03-12 |
| NZ507083A (en) | 2003-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 37, 8O, 13 DA LPI 9279/06 |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/04/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/04/2019, OBSERVADAS AS CONDICOES LEGAIS |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/03/1999 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 22/03/2019 |