BR9909697A - Processo para preparação de 1h-indol-3-glioxamidas 4-substituìdas - Google Patents

Processo para preparação de 1h-indol-3-glioxamidas 4-substituìdas

Info

Publication number
BR9909697A
BR9909697A BR9909697-8A BR9909697A BR9909697A BR 9909697 A BR9909697 A BR 9909697A BR 9909697 A BR9909697 A BR 9909697A BR 9909697 A BR9909697 A BR 9909697A
Authority
BR
Brazil
Prior art keywords
indole
substituted
preparation
glyoxamides
preparing
Prior art date
Application number
BR9909697-8A
Other languages
English (en)
Inventor
Benjamin Alan Anderson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9909697A publication Critical patent/BR9909697A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA PREPARAçãO DE 1H-INDOL-3-GLIOXAMIDAS 4-SUBSTITUìDAS"<D>. Esta invenção refere-se a um processo para preparar 1H-indol-3-glioxamidas úteis para inibir SPLA~ 2~ e a novos intermediários úteis na preparação de tais compostos.
BR9909697-8A 1998-04-17 1999-04-15 Processo para preparação de 1h-indol-3-glioxamidas 4-substituìdas BR9909697A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8211098P 1998-04-17 1998-04-17
PCT/US1999/008332 WO1999054300A1 (en) 1998-04-17 1999-04-15 Process for preparing 4-substituted-1h-indole-3-glyoxamides

Publications (1)

Publication Number Publication Date
BR9909697A true BR9909697A (pt) 2000-12-19

Family

ID=22169126

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909697-8A BR9909697A (pt) 1998-04-17 1999-04-15 Processo para preparação de 1h-indol-3-glioxamidas 4-substituìdas

Country Status (27)

Country Link
US (1) US6265591B1 (pt)
EP (1) EP1071663A4 (pt)
JP (1) JP2002512225A (pt)
KR (1) KR20010042741A (pt)
CN (1) CN1305459A (pt)
AR (1) AR015767A1 (pt)
AU (1) AU750368B2 (pt)
BR (1) BR9909697A (pt)
CA (1) CA2326515A1 (pt)
CO (1) CO5080803A1 (pt)
DZ (1) DZ2770A1 (pt)
EA (1) EA003582B1 (pt)
EG (1) EG22139A (pt)
HK (1) HK1039120A1 (pt)
HR (1) HRP20000685A2 (pt)
HU (1) HUP0101344A3 (pt)
ID (1) ID26021A (pt)
IL (1) IL138827A0 (pt)
NO (1) NO20005148L (pt)
NZ (1) NZ507175A (pt)
PE (1) PE20000430A1 (pt)
PL (1) PL343487A1 (pt)
SK (1) SK15372000A3 (pt)
SV (1) SV1999000043A (pt)
TR (1) TR200002999T2 (pt)
WO (1) WO1999054300A1 (pt)
ZA (1) ZA200005294B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2326505A1 (en) * 1998-04-17 1999-10-28 Nancy Kay Harn Process for preparing 4-hydroxy indole, indazole and carbazole compounds
US6407261B1 (en) 1998-04-17 2002-06-18 Eli Lilly And Company Process for preparing 4-hdyroxy indole, indazole and carbazole compounds
DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
US20030225149A1 (en) * 2002-04-30 2003-12-04 Blazecka Peter G. Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids
NZ720946A (en) 2009-04-29 2017-09-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
AR088377A1 (es) 2011-10-20 2014-05-28 Siena Biotech Spa Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3109974B2 (ja) * 1994-04-01 2000-11-20 イーライ・リリー・アンド・カンパニー １Ｈ−インドール−３−グリオキシルアミドｓＰＬＡ２阻害剤
CA2326505A1 (en) * 1998-04-17 1999-10-28 Nancy Kay Harn Process for preparing 4-hydroxy indole, indazole and carbazole compounds

Also Published As

Publication number Publication date
WO1999054300A1 (en) 1999-10-28
ZA200005294B (en) 2001-10-01
HK1039120A1 (zh) 2002-04-12
KR20010042741A (ko) 2001-05-25
HUP0101344A3 (en) 2002-12-28
AU750368B2 (en) 2002-07-18
DZ2770A1 (fr) 2003-12-01
AR015767A1 (es) 2001-05-16
EP1071663A1 (en) 2001-01-31
CN1305459A (zh) 2001-07-25
TR200002999T2 (tr) 2001-01-22
EP1071663A4 (en) 2002-06-19
ID26021A (id) 2000-11-16
CA2326515A1 (en) 1999-10-28
HUP0101344A2 (hu) 2001-09-28
AU3564899A (en) 1999-11-08
SV1999000043A (es) 2000-05-02
JP2002512225A (ja) 2002-04-23
EA003582B1 (ru) 2003-06-26
PL343487A1 (en) 2001-08-27
PE20000430A1 (es) 2000-05-24
US6265591B1 (en) 2001-07-24
SK15372000A3 (sk) 2001-08-06
NO20005148L (no) 2000-11-09
EA200001076A1 (ru) 2001-04-23
IL138827A0 (en) 2001-10-31
CO5080803A1 (es) 2001-09-25
NO20005148D0 (no) 2000-10-13
NZ507175A (en) 2002-12-20
EG22139A (en) 2002-08-30
HRP20000685A2 (en) 2001-10-31

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6O, 7O E 8O ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.