BR9910005A - Composição de vacina, processos para imunização contra neisseria gonorrhoeae e para preparar uma composição de vacina, sequência de dna isolada e purificada, plasmìdeo, célula hospedeira, processo para produção de uma proteìna pilina recombinante quimérica de neisseria gonorrhoeae e neisseria meningitidis, proteìna pilina recombinante quimérica isolada e purificada de neisseria gonorhoeae e neisseria meningitidis, e, processo para imunização contra neisseria muningitidis - Google Patents
Composição de vacina, processos para imunização contra neisseria gonorrhoeae e para preparar uma composição de vacina, sequência de dna isolada e purificada, plasmìdeo, célula hospedeira, processo para produção de uma proteìna pilina recombinante quimérica de neisseria gonorrhoeae e neisseria meningitidis, proteìna pilina recombinante quimérica isolada e purificada de neisseria gonorhoeae e neisseria meningitidis, e, processo para imunização contra neisseria muningitidisInfo
- Publication number
- BR9910005A BR9910005A BR9910005-3A BR9910005A BR9910005A BR 9910005 A BR9910005 A BR 9910005A BR 9910005 A BR9910005 A BR 9910005A BR 9910005 A BR9910005 A BR 9910005A
- Authority
- BR
- Brazil
- Prior art keywords
- neisseria
- protein
- vaccine composition
- isolated
- neisseria meningitidis
- Prior art date
Links
- 241000588650 Neisseria meningitidis Species 0.000 title abstract 9
- 241000588652 Neisseria gonorrhoeae Species 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 6
- 108010000916 Fimbriae Proteins Proteins 0.000 title abstract 5
- 229960005486 vaccine Drugs 0.000 title abstract 5
- 230000003053 immunization Effects 0.000 title abstract 4
- 238000002649 immunization Methods 0.000 title abstract 4
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title abstract 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title abstract 2
- 239000013612 plasmid Substances 0.000 title abstract 2
- 241000588653 Neisseria Species 0.000 title 2
- 101150002077 pilE gene Proteins 0.000 abstract 5
- 101100446858 Neisseria gonorrhoeae pilE gene Proteins 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 101001059401 Moraxella bovis Type IV major alpha-pilin Proteins 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"COMPOSIçãO DE VACINA, PROCESSOS PARA IMUNIZAçãO CONTRA NEISSERIA GONORRHOEAE E PARA PREPARAR UMA COMPOSIçãO DE VACINA, SEQuêNCIA DE DNA ISOLADA E PURIFICADA, PLASMìDEO, CéLULA HOSPEDEIRA, PROCESSO PARA PRODUçãO DE UMA PROTEìNA PILINA RECOMBINANTE QUIMéRICA DE NEISSERIA GONORRHOEAE E NEISSERIA MENINGITIDIS, PROTEìNA PILINA RECOMBINANTE QUIMéRICA ISOLADA E PURIFICADA DE NEISSERIA GONORRHOEAE E NEISSERIA MENINGITIDIS, E, PROCESSO PARA IMUNIZAçãO CONTRA NEISSERIA MENINGITIDIS" Os genes pilE de cada uma das Neisseria gonorrhoeae e Neisseria meningitidis são clonados e suas proteínas pilinas recombinantes correspondentes são expressas. Além disso, é construído um gene pilE quimérico em que a região do gene pilE de Neisseria meningitidis Classe I codificando a região terminal amino da proteína pilina é substituída pela região correspondente do gene pilE de Neisseria gonorrhoeae. A proteína pilina classe I quimérica meningocócica recombinante é expressa em níveis mais elevados do que a proteína pilina expressa pelo gene pilE de comprimento completo de Neisseria meningitidis. Além disso, é construído um gene pilE quimérico em que a região do gene pilE de Neisseria meningitidis classe II codificando a região terminal carbóxi da proteína pilina é substituída pela região correspondente do gene pilE de Neisseria gonorrhoeae. As proteínas pilinas recombinantes são usadas em vacinas, para proteger contra doença causada por Neisseria gonorrhoeae ou por Neisseria meningitidis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8340598P | 1998-04-29 | 1998-04-29 | |
| PCT/US1999/009486 WO1999055875A2 (en) | 1998-04-29 | 1999-04-29 | VACCINES CONTAINING RECOMBINANT PILIN AGAINST NEISSERIA GONORRHOEAE OR $i(NEISSERIA MENINGITIDIS) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9910005A true BR9910005A (pt) | 2001-01-16 |
Family
ID=22178094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9910005-3A BR9910005A (pt) | 1998-04-29 | 1999-04-29 | Composição de vacina, processos para imunização contra neisseria gonorrhoeae e para preparar uma composição de vacina, sequência de dna isolada e purificada, plasmìdeo, célula hospedeira, processo para produção de uma proteìna pilina recombinante quimérica de neisseria gonorrhoeae e neisseria meningitidis, proteìna pilina recombinante quimérica isolada e purificada de neisseria gonorhoeae e neisseria meningitidis, e, processo para imunização contra neisseria muningitidis |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1073748A2 (pt) |
| JP (1) | JP2002527041A (pt) |
| KR (4) | KR20060118628A (pt) |
| CN (1) | CN1245512C (pt) |
| AU (2) | AU3968599A (pt) |
| BR (1) | BR9910005A (pt) |
| CA (1) | CA2325055A1 (pt) |
| IL (1) | IL139311A0 (pt) |
| WO (1) | WO1999055875A2 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0011108D0 (en) * | 2000-05-08 | 2000-06-28 | Microscience Ltd | Virulence gene and protein and their use |
| GB0118249D0 (en) * | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| WO2005098028A1 (en) * | 2004-04-08 | 2005-10-20 | The State Of Queensland Acting Through Its Department Of Health | Neisseria gonorrhoeae detection |
| US20110182981A1 (en) * | 2008-08-25 | 2011-07-28 | Peixuan Zhu | Gonococcal vaccines |
| US9802988B2 (en) * | 2009-05-20 | 2017-10-31 | University Of Maryland, Baltimore | Engineered type IV pilin of Clostridium difficile |
| EP2635593B1 (en) * | 2010-11-05 | 2016-09-14 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Vaccines for preventing meningococcal infections |
| JP5991740B2 (ja) * | 2012-06-21 | 2016-09-14 | キヤノン株式会社 | ライセンス管理装置、ライセンス管理方法、およびプログラム |
| HK1205138A1 (en) | 2012-07-27 | 2015-12-11 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Cd147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia |
| CN103405760A (zh) * | 2013-06-19 | 2013-11-27 | 中国科学院海洋研究所 | 迟缓爱德华氏菌菌毛蛋白FimA的应用 |
| CN106290849A (zh) * | 2015-05-13 | 2017-01-04 | 上海凯创生物技术有限公司 | 一种脑膜炎菌胶体金检测试剂盒 |
| CN118994336B (zh) * | 2024-10-22 | 2025-01-24 | 四川大学华西医院 | 鲍曼不动杆菌菌毛重组蛋白抗原、制备方法及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2617870A1 (de) * | 1975-04-25 | 1976-12-30 | Bactex Inc | Pili von neisseria genorrhoeae und verfahren zu deren herstellung |
| EP0049945A3 (en) * | 1980-09-15 | 1982-12-01 | Bactex Incorporated | Determining a hierarchy of piliated organisms and a vaccine prepared from such organisms |
| US4443431A (en) * | 1981-05-27 | 1984-04-17 | The United States Of America As Represented By The Department Of Health And Human Services | Neisseria gonorrhoeae vaccine |
| AU582358B2 (en) * | 1984-04-06 | 1989-03-23 | Scripps Clinic And Research Foundation | A peptide vaccine or diagnostic, and a polypeptide useful therefor |
| CU22302A1 (es) * | 1990-09-07 | 1995-01-31 | Cigb | Secuencia nucleotidica codificante para una proteina de la membrana externa de neisseria meningitidis y uso de dicha proteina en preparados vacunales |
| AU1411492A (en) * | 1991-01-31 | 1992-09-07 | Washington University | Polypeptides and polynucleotides useful for the diagnosis and treatment of pathogenic neisseria |
| AU3416693A (en) * | 1991-12-18 | 1993-07-19 | State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University, The | Antigenic preparations that stimulate production of antibodies which bind to the pili of type IV piliated bacteria |
| CA2138997C (en) * | 1992-06-25 | 2003-06-03 | Jean-Paul Prieels | Vaccine composition containing adjuvants |
| AU5403594A (en) * | 1992-10-07 | 1994-04-26 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | Pilin variants and uses thereof |
| US6265567B1 (en) * | 1995-04-07 | 2001-07-24 | University Of North Carolina At Chapel Hill | Isolated FrpB nucleic acid molecule |
-
1999
- 1999-04-29 BR BR9910005-3A patent/BR9910005A/pt not_active IP Right Cessation
- 1999-04-29 CN CNB998056014A patent/CN1245512C/zh not_active Expired - Fee Related
- 1999-04-29 JP JP2000546019A patent/JP2002527041A/ja not_active Withdrawn
- 1999-04-29 CA CA002325055A patent/CA2325055A1/en not_active Abandoned
- 1999-04-29 KR KR1020067022726A patent/KR20060118628A/ko not_active Ceased
- 1999-04-29 KR KR1020067022731A patent/KR20060118630A/ko not_active Ceased
- 1999-04-29 IL IL13931199A patent/IL139311A0/xx unknown
- 1999-04-29 EP EP99922760A patent/EP1073748A2/en not_active Withdrawn
- 1999-04-29 KR KR1020067022728A patent/KR20060118629A/ko not_active Ceased
- 1999-04-29 AU AU39685/99A patent/AU3968599A/en not_active Abandoned
- 1999-04-29 WO PCT/US1999/009486 patent/WO1999055875A2/en not_active Ceased
- 1999-04-29 KR KR1020007011991A patent/KR20010043105A/ko not_active Ceased
-
2003
- 2003-06-16 AU AU2003204738A patent/AU2003204738B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2325055A1 (en) | 1999-11-04 |
| AU2003204738B2 (en) | 2006-09-14 |
| WO1999055875A3 (en) | 2000-04-13 |
| EP1073748A2 (en) | 2001-02-07 |
| AU3968599A (en) | 1999-11-16 |
| KR20060118630A (ko) | 2006-11-23 |
| WO1999055875A2 (en) | 1999-11-04 |
| CN1245512C (zh) | 2006-03-15 |
| KR20010043105A (ko) | 2001-05-25 |
| CN1298446A (zh) | 2001-06-06 |
| KR20060118628A (ko) | 2006-11-23 |
| KR20060118629A (ko) | 2006-11-23 |
| IL139311A0 (en) | 2001-11-25 |
| JP2002527041A (ja) | 2002-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DEPACHO 8.6 DA RPI 1994 DE 24/03/2009 |