BR9911097A - Método para ensaio fagocìtico - Google Patents

Método para ensaio fagocìtico

Info

Publication number
BR9911097A
BR9911097A BR9911097-0A BR9911097A BR9911097A BR 9911097 A BR9911097 A BR 9911097A BR 9911097 A BR9911097 A BR 9911097A BR 9911097 A BR9911097 A BR 9911097A
Authority
BR
Brazil
Prior art keywords
phagocytosis
apoptotic
cells
apoptotic cells
compound
Prior art date
Application number
BR9911097-0A
Other languages
English (en)
Inventor
Elke Smits
Wim Maria Rene Van Criekinge
Thierry Andre Oliver E Bogaert
Original Assignee
Devgen Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9812660.0A external-priority patent/GB9812660D0/en
Priority claimed from GBGB9820816.8A external-priority patent/GB9820816D0/en
Application filed by Devgen Nv filed Critical Devgen Nv
Publication of BR9911097A publication Critical patent/BR9911097A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • C07K14/4354—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes
    • C07K14/43545—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes from Caenorhabditis
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

''MéTODO PARA ENSAIO FAGOCìTICO'' A invenção provê processos de ensaio para determinação de se um composto é um aperfeiçoador ou um inibidor de um caminho de transdução de sinal que promove fagocitose de células apoptóticas. Os processos envolvem exposição de uma célula fagocítica a células apoptóticas, opcionalmente transfectadas com um gene repórter, e medindo-se a extensão de fagocitose na presença ou ausência do composto teste. Vetores de expressão são providos para transfectar células mamíferas com seq³ências de DNA que quando expressas influenciam a taxa de fagocitose de células apoptóticas tal como o homólogo humano do gene ced-6 de C.elegans.
BR9911097-0A 1998-06-11 1999-06-10 Método para ensaio fagocìtico BR9911097A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9812660.0A GB9812660D0 (en) 1998-06-11 1998-06-11 Engulfment gene and uses thereof
GBGB9820816.8A GB9820816D0 (en) 1998-09-24 1998-09-24 Engulfment gene and uses thereof
PCT/EP1999/004043 WO1999064586A2 (en) 1998-06-11 1999-06-10 Phagocytic assay method

Publications (1)

Publication Number Publication Date
BR9911097A true BR9911097A (pt) 2001-02-13

Family

ID=26313846

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9911097-0A BR9911097A (pt) 1998-06-11 1999-06-10 Método para ensaio fagocìtico

Country Status (11)

Country Link
EP (1) EP1084242A2 (pt)
JP (1) JP2002517238A (pt)
KR (1) KR20010071453A (pt)
CN (1) CN1305525A (pt)
AU (1) AU4608499A (pt)
BR (1) BR9911097A (pt)
CA (1) CA2332993A1 (pt)
HU (1) HUP0102349A2 (pt)
IL (1) IL140016A0 (pt)
PL (1) PL345951A1 (pt)
WO (1) WO1999064586A2 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020004041A1 (en) * 1999-02-19 2002-01-10 Albert Matthew L. Methods for abrogating a cellular immune response
US6489535B1 (en) 1999-03-18 2002-12-03 The Board Of Trustees Of The Leland Stanford Junior University Non-mammalian transgenic animal having an adult onset neurodegenerative phenotype
US6316690B1 (en) 1999-08-04 2001-11-13 Tosk, Inc. Non-mammalian transgenic animal model for cellular proliferative diseases
US6365129B1 (en) 1999-08-04 2002-04-02 Tosk, Inc. Invivo high throughput toxicology screening method
US7615676B2 (en) 2001-11-30 2009-11-10 U.S. Department Of Veterans Affairs Transgenic screen and method for screening modulators of brain-derived neurotrophic factor (BDNF) production
US7491810B2 (en) * 2001-11-30 2009-02-17 U.S. Department Of Veterans Affairs Transgenic screen and method for screening modulators of brain-derived neurotrophic factor (BDNF) production
WO2018212612A1 (ko) * 2017-05-17 2018-11-22 울산과학기술원 자성 입자를 이용한 면역세포의 평가 방법 및 장치
KR102213080B1 (ko) * 2017-05-17 2021-02-08 울산과학기술원 자성 입자를 이용한 면역세포의 평가방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232061B1 (en) * 1992-04-01 2001-05-15 Cambridge Neuroscience, Inc. Homology cloning

Also Published As

Publication number Publication date
CA2332993A1 (en) 1999-12-16
HUP0102349A2 (hu) 2001-10-28
JP2002517238A (ja) 2002-06-18
AU4608499A (en) 1999-12-30
EP1084242A2 (en) 2001-03-21
WO1999064586A3 (en) 2000-04-27
PL345951A1 (en) 2002-01-14
CN1305525A (zh) 2001-07-25
KR20010071453A (ko) 2001-07-28
IL140016A0 (en) 2002-02-10
WO1999064586A2 (en) 1999-12-16

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]