BR9914677A - Heterociclos de nitrogênio bicìclicos - Google Patents

Heterociclos de nitrogênio bicìclicos

Info

Publication number
BR9914677A
BR9914677A BR9914677-0A BR9914677A BR9914677A BR 9914677 A BR9914677 A BR 9914677A BR 9914677 A BR9914677 A BR 9914677A BR 9914677 A BR9914677 A BR 9914677A
Authority
BR
Brazil
Prior art keywords
lower alkyl
heteroaryl
aryl
cycloalkyl
alkyl
Prior art date
Application number
BR9914677-0A
Other languages
English (en)
Inventor
William Harris
Christopher Huw Hill
Ian Edward David Smith
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26314565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9914677(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9823277.0A external-priority patent/GB9823277D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9914677A publication Critical patent/BR9914677A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Inorganic Insulating Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Patente de Invenção: <B>"HETEROCICLOS DE NITROGêNIO BICìCLICOS"<D>. Diidropirimidino[4,5-d]pirimidinonas amino-substituídas da fórmula (I) em que R¹ representa hidrogênio, alquila inferior, arila, aril-alquila inferior, heteroarila, heteroaril-alquila inferior, cicloalquila inferior ou cicloalquila inferior-alquila inferior, R² representa alquila inferior, arila, aril-alquila inferior, heteroarila, heteroaril-alquila inferior, cicloalquila inferior ou cicloalquila inferior-alquila inferior, e R³ representa hidrogênio, alquila inferior, arila, aril-alquila inferior, heteroarila, heteroaril-alquila inferior, cicloalquila inferior, cicloalquenila inferior ou cicloalquila inferior-alquila inferior, e seus sais farmaceuticamente aceitáveis são inibidores de cinase de proteína. Elas podem ser usadas no tratamento ou profilaxia de distúrbios inflamatórios, imunológicos, oncológicos, broncopulmonares, dermatológicos e cardiovasculares, no tratamento de asma, distúrbios do sistema nervoso central ou complicações diabéticas ou para a prevenção de rejeição de enxerto após cirurgia de transplante.
BR9914677-0A 1998-10-23 1999-10-13 Heterociclos de nitrogênio bicìclicos BR9914677A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9823277.0A GB9823277D0 (en) 1998-10-23 1998-10-23 Bicycle nitrogen heterocycles
GBGB9920044.6A GB9920044D0 (en) 1998-10-23 1999-08-24 Biciclic nitrogen heterocycles
PCT/EP1999/007675 WO2000024744A1 (en) 1998-10-23 1999-10-13 Bicyclic nitrogen heterocycles

Publications (1)

Publication Number Publication Date
BR9914677A true BR9914677A (pt) 2001-07-17

Family

ID=26314565

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9914677-0A BR9914677A (pt) 1998-10-23 1999-10-13 Heterociclos de nitrogênio bicìclicos

Country Status (25)

Country Link
US (1) US6150373A (pt)
EP (1) EP1123295B1 (pt)
JP (1) JP3593035B2 (pt)
CN (1) CN1150195C (pt)
AT (1) ATE277931T1 (pt)
AU (1) AU769989B2 (pt)
BR (1) BR9914677A (pt)
CA (1) CA2347474C (pt)
CZ (1) CZ20011394A3 (pt)
DE (1) DE69920732T2 (pt)
ES (1) ES2228123T3 (pt)
HK (1) HK1041483B (pt)
HR (1) HRP20010274A2 (pt)
HU (1) HUP0104199A3 (pt)
ID (1) ID28276A (pt)
MA (1) MA27678A1 (pt)
MY (1) MY126478A (pt)
NO (1) NO318802B1 (pt)
NZ (1) NZ510760A (pt)
PL (1) PL347432A1 (pt)
PT (1) PT1123295E (pt)
RU (1) RU2256662C2 (pt)
TR (1) TR200101102T2 (pt)
TW (1) TWI227235B (pt)
WO (1) WO2000024744A1 (pt)

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Also Published As

Publication number Publication date
HK1041483A1 (en) 2002-07-12
NO20011929L (no) 2001-04-19
AU769989B2 (en) 2004-02-12
RU2256662C2 (ru) 2005-07-20
HUP0104199A2 (hu) 2002-04-29
CN1150195C (zh) 2004-05-19
DE69920732T2 (de) 2006-02-23
ID28276A (id) 2001-05-10
HK1041483B (zh) 2004-12-24
MA27678A1 (fr) 2006-01-02
JP2002528455A (ja) 2002-09-03
CZ20011394A3 (cs) 2001-12-12
EP1123295A1 (en) 2001-08-16
CN1324360A (zh) 2001-11-28
HUP0104199A3 (en) 2002-12-28
TR200101102T2 (tr) 2002-01-21
US6150373A (en) 2000-11-21
CA2347474A1 (en) 2000-05-04
CA2347474C (en) 2008-08-26
MY126478A (en) 2006-10-31
PL347432A1 (en) 2002-04-08
NZ510760A (en) 2003-08-29
AU1036300A (en) 2000-05-15
NO20011929D0 (no) 2001-04-19
TWI227235B (en) 2005-02-01
HRP20010274A2 (en) 2002-06-30
ATE277931T1 (de) 2004-10-15
EP1123295B1 (en) 2004-09-29
ES2228123T3 (es) 2005-04-01
JP3593035B2 (ja) 2004-11-24
NO318802B1 (no) 2005-05-09
PT1123295E (pt) 2005-01-31
DE69920732D1 (de) 2004-11-04
WO2000024744A1 (en) 2000-05-04

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