BR9916331A - Derivado dos ácidos beta-amido ou beta-sulfonamido carboxìlico, uso do mesmo, preparação farmacêutica para administração oral, parenteral e intraperitoneal, composto, uso deste, e, fragmento estrutura - Google Patents
Derivado dos ácidos beta-amido ou beta-sulfonamido carboxìlico, uso do mesmo, preparação farmacêutica para administração oral, parenteral e intraperitoneal, composto, uso deste, e, fragmento estruturaInfo
- Publication number
- BR9916331A BR9916331A BR9916331-4A BR9916331A BR9916331A BR 9916331 A BR9916331 A BR 9916331A BR 9916331 A BR9916331 A BR 9916331A BR 9916331 A BR9916331 A BR 9916331A
- Authority
- BR
- Brazil
- Prior art keywords
- beta
- nitrogen
- starch
- oral
- derived
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000012634 fragment Substances 0.000 title abstract 3
- 238000007912 intraperitoneal administration Methods 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 229920002472 Starch Polymers 0.000 title 1
- 238000007911 parenteral administration Methods 0.000 title 1
- 239000008107 starch Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 7
- 229910052757 nitrogen Inorganic materials 0.000 abstract 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 5
- 229940118365 Endothelin receptor antagonist Drugs 0.000 abstract 2
- 239000002308 endothelin receptor antagonist Substances 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/22—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to two ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"DERIVADO DOS áCIDOS BETA-AMIDO OU BETA-SULFONAMIDO CARBOXìLICO, USO DO MESMO, PREPARAçãO FARMACêUTICA PARA ADMINISTRAçãO ORAL, PARENTERAL E INTRAPERITONEAL, COMPOSTO, USO DESTE, E, FRAGMENTO ESTRUTURAL". A invenção diz respeito a derivados de ácido carboxílico da fórmula (I): na qual os substituintes têm os seguintes significados: R¹ é tetrazol ou um grupo (a); W e Z, podem ser idênticos ou diferentes e são nitrogênio ou metina, contanto que, se W e Z são metina, então Q é nitrogênio; X é nitrogênio ou CR^ 9^; Y é nitrogênio ou CR^ 10^; Q é nitrogênio ou CR^ 11^, contanto que, se Q é nitrogênio então X é CR^ 5^ e Y é CR^ 10^; R² e R³ são idênticos ou diferentes e são, possivelmente fenila ou naftila substituídas ou fenila ou naftila que são ligadas em um posição orto por uma ligação direta, um grupo metileno, etileno ou etenileno, um átomo de oxigênio ou de enxofre ou um grupo SO~ 2~-, NH- ou N-alquila ou possivelmente cicloalquila C~ 5~-C~ 6~ substituída; R^ 4^ é um resto de (b) ou (c); e R^ 5^ é hidrogênio, alquila C~ 1~-C~ 4~. A invenção ainda diz respeito a sua preparação e ao seu uso como antagonistas do receptor de endotelina. A invenção também diz respeito a compostos da fórmula (II) e a um fragmento estrutural da fórmula (d) em que os restos de R¹, R², R³, R^ 4^ e R^ 5^ têm os significados dados na reivindicação no. 1 e a seu uso como elementos estruturais em um antagonista do receptor de endotelina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19858779A DE19858779A1 (de) | 1998-12-18 | 1998-12-18 | Neue ß-Amido und ß-Sulfonamidocarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten |
| PCT/EP1999/009679 WO2000037450A1 (de) | 1998-12-18 | 1999-12-09 | NEUE β-AMIDO- UND β-SULFONAMIDOCARBONSÄUREDERIVATE, IHRE HERSTELLUNG UND VERWENDUNG ALS ENDOTHELIN-REZEPTORANTAGONISTEN |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9916331A true BR9916331A (pt) | 2001-09-11 |
Family
ID=7891778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9916331-4A BR9916331A (pt) | 1998-12-18 | 1999-12-09 | Derivado dos ácidos beta-amido ou beta-sulfonamido carboxìlico, uso do mesmo, preparação farmacêutica para administração oral, parenteral e intraperitoneal, composto, uso deste, e, fragmento estrutura |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1140867A1 (pt) |
| JP (1) | JP2002533330A (pt) |
| KR (1) | KR20010101279A (pt) |
| CN (1) | CN1334806A (pt) |
| AR (1) | AR023353A1 (pt) |
| AU (1) | AU3036400A (pt) |
| BG (1) | BG105618A (pt) |
| BR (1) | BR9916331A (pt) |
| CA (1) | CA2355251A1 (pt) |
| CZ (1) | CZ20012186A3 (pt) |
| DE (1) | DE19858779A1 (pt) |
| HK (1) | HK1042095A1 (pt) |
| HU (1) | HUP0201321A3 (pt) |
| IL (1) | IL143451A0 (pt) |
| NO (1) | NO20013000L (pt) |
| SK (1) | SK8682001A3 (pt) |
| TR (1) | TR200101780T2 (pt) |
| WO (1) | WO2000037450A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60113290D1 (de) * | 2000-11-17 | 2005-10-13 | Warner Lambert Co | Behandlung von sexueller funktionsstörung mit bombesin rezeptor antagonisten |
| US7790770B2 (en) | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| JP5531097B2 (ja) * | 2009-07-10 | 2014-06-25 | カディラ・ヘルスケア・リミテッド | アンブリセンタンを調製するための改善された方法およびその新規な中間体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8912700D0 (en) * | 1989-06-02 | 1989-07-19 | Shell Int Research | Herbicidal compounds |
| DE4329911A1 (de) * | 1993-09-04 | 1995-03-09 | Basf Ag | Substituierte Milchsäurederivate mit einem N-organischen Rest in beta-Position |
| CA2275256A1 (en) * | 1996-12-18 | 1998-06-25 | Basf Aktiengesellschaft | Heterocyclic carboxylic acid derivatives, the production and use thereof as endothelin receptor antagonists |
| DE19726146A1 (de) * | 1997-06-19 | 1998-12-24 | Basf Ag | Neue ß-Amino und ß-Azidopcarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten |
-
1998
- 1998-12-18 DE DE19858779A patent/DE19858779A1/de not_active Withdrawn
-
1999
- 1999-12-09 BR BR9916331-4A patent/BR9916331A/pt not_active Application Discontinuation
- 1999-12-09 AU AU30364/00A patent/AU3036400A/en not_active Abandoned
- 1999-12-09 KR KR1020017007615A patent/KR20010101279A/ko not_active Ceased
- 1999-12-09 CZ CZ20012186A patent/CZ20012186A3/cs unknown
- 1999-12-09 TR TR2001/01780T patent/TR200101780T2/xx unknown
- 1999-12-09 JP JP2000589522A patent/JP2002533330A/ja active Pending
- 1999-12-09 WO PCT/EP1999/009679 patent/WO2000037450A1/de not_active Ceased
- 1999-12-09 EP EP99964533A patent/EP1140867A1/de not_active Withdrawn
- 1999-12-09 CN CN99814580A patent/CN1334806A/zh active Pending
- 1999-12-09 CA CA002355251A patent/CA2355251A1/en not_active Abandoned
- 1999-12-09 HK HK02104116.9A patent/HK1042095A1/zh unknown
- 1999-12-09 SK SK868-2001A patent/SK8682001A3/sk unknown
- 1999-12-09 IL IL14345199A patent/IL143451A0/xx unknown
- 1999-12-09 HU HU0201321A patent/HUP0201321A3/hu unknown
- 1999-12-17 AR ARP990106523A patent/AR023353A1/es unknown
-
2001
- 2001-06-15 NO NO20013000A patent/NO20013000L/no not_active Application Discontinuation
- 2001-06-18 BG BG105618A patent/BG105618A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20012186A3 (cs) | 2002-07-17 |
| TR200101780T2 (tr) | 2001-11-21 |
| HUP0201321A2 (hu) | 2002-12-28 |
| WO2000037450A1 (de) | 2000-06-29 |
| NO20013000L (no) | 2001-08-15 |
| SK8682001A3 (en) | 2002-08-06 |
| AR023353A1 (es) | 2002-09-04 |
| DE19858779A1 (de) | 2000-06-21 |
| NO20013000D0 (no) | 2001-06-15 |
| BG105618A (en) | 2002-01-31 |
| HK1042095A1 (zh) | 2002-08-02 |
| JP2002533330A (ja) | 2002-10-08 |
| HUP0201321A3 (en) | 2003-02-28 |
| CN1334806A (zh) | 2002-02-06 |
| EP1140867A1 (de) | 2001-10-10 |
| IL143451A0 (en) | 2002-04-21 |
| KR20010101279A (ko) | 2001-11-14 |
| AU3036400A (en) | 2000-07-12 |
| CA2355251A1 (en) | 2000-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |