BRPI0009249A - formulação farmacêutica parenteral de equinocandina contendo tensoativos de formação de micela. - Google Patents

formulação farmacêutica parenteral de equinocandina contendo tensoativos de formação de micela.

Info

Publication number
BRPI0009249A
BRPI0009249A BRPI0009249A BRPI0009249A BRPI0009249A BR PI0009249 A BRPI0009249 A BR PI0009249A BR PI0009249 A BRPI0009249 A BR PI0009249A BR PI0009249 A BRPI0009249 A BR PI0009249A BR PI0009249 A BRPI0009249 A BR PI0009249A
Authority
BR
Brazil
Prior art keywords
echinocandin
formulations
pharmaceutical formulation
forming surfactants
containing micelle
Prior art date
Application number
BRPI0009249A
Other languages
English (en)
Inventor
Nathaniel Milton
Kenneth Philip Moder
James Lawrence Sabatowski
Stephanie Ann Sweetana
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22403808&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0009249(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BRPI0009249A publication Critical patent/BRPI0009249A/pt
Publication of BRPI0009249B1 publication Critical patent/BRPI0009249B1/pt
Publication of BRPI0009249B8 publication Critical patent/BRPI0009249B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

patente de invenção: "formulações farmacêuticas de equinocandina contendo tensoativos de formação de micela". são descritas formulações farmacêuticas compreendendo um composto equinocandina ou complexo de equinocandina/carboidrato e um tensoativo de formação de micela farmaceuticamente aceitável em um solvente aquoso não-tóxico, tal que a solubilização do composto de quinocandina é otimizada e a capacidade de secar por congelamento da solução é mantida. a soluções e as formulações secas por congelamento possuem estabilidade aumentada. um agente de volume, agente de tonicidade, tampão e/ou agente estabilizante podem opcionalmente ser adicionados às formulações para melhorar adicionalmente a estabilidade da formulação.
BRPI0009249-5 1999-03-03 2000-03-02 formulação farmacêutica parenteral de equinocandina contendo tensoativos de formação de micela. BRPI0009249B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12262399P 1999-03-03 1999-03-03
PCT/US2000/005546 WO2000051564A1 (en) 1999-03-03 2000-03-02 Echinocandin pharmaceutical formulations containing micelle-forming surfactants

Publications (3)

Publication Number Publication Date
BRPI0009249A true BRPI0009249A (pt) 2001-11-20
BRPI0009249B1 BRPI0009249B1 (pt) 2011-11-29
BRPI0009249B8 BRPI0009249B8 (pt) 2021-07-06

Family

ID=22403808

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0009249-5 BRPI0009249B8 (pt) 1999-03-03 2000-03-02 formulação farmacêutica parenteral de equinocandina contendo tensoativos de formação de micela.

Country Status (19)

Country Link
US (2) US6960564B2 (pt)
EP (2) EP1582204B1 (pt)
JP (2) JP4936595B2 (pt)
KR (1) KR100613136B1 (pt)
CN (1) CN100335122C (pt)
AT (1) ATE294571T1 (pt)
AU (1) AU776782C (pt)
BR (1) BRPI0009249B8 (pt)
CA (1) CA2362481C (pt)
CY (2) CY1114631T1 (pt)
DE (1) DE60019902D1 (pt)
DK (1) DK1582204T3 (pt)
ES (1) ES2433678T3 (pt)
HK (1) HK1040062A1 (pt)
IL (1) IL145185A0 (pt)
PT (1) PT1582204E (pt)
RU (1) RU2250763C2 (pt)
WO (1) WO2000051564A1 (pt)
ZA (1) ZA200108002B (pt)

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US7709444B2 (en) 2010-05-04
EP1582204B1 (en) 2013-09-25
ATE294571T1 (de) 2005-05-15
WO2000051564A8 (en) 2002-05-30
EP1156782A1 (en) 2001-11-28
BRPI0009249B8 (pt) 2021-07-06
US20030054981A1 (en) 2003-03-20
AU3249100A (en) 2000-09-21
PT1582204E (pt) 2013-11-25
JP4755464B2 (ja) 2011-08-24
HK1074803A1 (en) 2005-11-25
KR100613136B1 (ko) 2006-08-17
EP1582204A3 (en) 2007-10-10
JP2005325142A (ja) 2005-11-24
HK1040062A1 (zh) 2002-05-24
CY2014003I2 (el) 2015-12-09
US20050192213A1 (en) 2005-09-01
AU776782C (en) 2005-04-07
US6960564B2 (en) 2005-11-01
CA2362481C (en) 2008-11-04
DE60019902D1 (de) 2005-06-09
BRPI0009249B1 (pt) 2011-11-29
CN1345229A (zh) 2002-04-17
WO2000051564A1 (en) 2000-09-08
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CN100335122C (zh) 2007-09-05
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IL145185A0 (en) 2002-06-30
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