BRPI0012329B8 - derivados de benzofurano, processo para sua preparação e uso dos mesmos. - Google Patents

derivados de benzofurano, processo para sua preparação e uso dos mesmos.

Info

Publication number
BRPI0012329B8
BRPI0012329B8 BRPI0012329A BR0012329A BRPI0012329B8 BR PI0012329 B8 BRPI0012329 B8 BR PI0012329B8 BR PI0012329 A BRPI0012329 A BR PI0012329A BR 0012329 A BR0012329 A BR 0012329A BR PI0012329 B8 BRPI0012329 B8 BR PI0012329B8
Authority
BR
Brazil
Prior art keywords
benzofuran derivatives
preparation
benzofuran
derivatives
medicines
Prior art date
Application number
BRPI0012329A
Other languages
English (en)
Other versions
BR0012329A (pt
BR0012329B1 (pt
Inventor
Bathe Andreas
Helfert Bernd
Boettcher Henning
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR0012329A publication Critical patent/BR0012329A/pt
Publication of BR0012329B1 publication Critical patent/BR0012329B1/pt
Publication of BRPI0012329B8 publication Critical patent/BRPI0012329B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

patente de invenção: "derivados de benzofurano". derivados de benzofurano da fórmula (i), em que r e r' têm os significados dados na reivindicação nn<0> (1), e seus sais são adequados para uso como produtos intermediários na síntese de medicamentos.
BRPI0012329A 1999-07-10 2000-06-29 derivados de benzofurano, processo para sua preparação e uso dos mesmos. BRPI0012329B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19932314A DE19932314A1 (de) 1999-07-10 1999-07-10 Benzofuranderivate
PCT/EP2000/006089 WO2001004112A2 (de) 1999-07-10 2000-06-29 Benzofuranderivate

Publications (3)

Publication Number Publication Date
BR0012329A BR0012329A (pt) 2002-03-19
BR0012329B1 BR0012329B1 (pt) 2013-03-19
BRPI0012329B8 true BRPI0012329B8 (pt) 2021-05-25

Family

ID=7914351

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0012329A BRPI0012329B8 (pt) 1999-07-10 2000-06-29 derivados de benzofurano, processo para sua preparação e uso dos mesmos.

Country Status (29)

Country Link
US (1) US6531503B1 (pt)
EP (1) EP1194426B1 (pt)
JP (1) JP4908706B2 (pt)
KR (1) KR100709378B1 (pt)
CN (1) CN1178934C (pt)
AR (1) AR024671A1 (pt)
AT (1) ATE273973T1 (pt)
AU (1) AU767413B2 (pt)
BR (1) BRPI0012329B8 (pt)
CA (1) CA2378603C (pt)
CZ (1) CZ301441B6 (pt)
DE (2) DE19932314A1 (pt)
DK (1) DK1194426T3 (pt)
ES (1) ES2226884T3 (pt)
HK (1) HK1047275B (pt)
HU (1) HU229135B1 (pt)
IL (2) IL147494A0 (pt)
MX (1) MXPA02000316A (pt)
MY (1) MY122667A (pt)
NO (1) NO328209B1 (pt)
PL (1) PL196477B1 (pt)
PT (1) PT1194426E (pt)
RU (1) RU2278862C2 (pt)
SI (1) SI1194426T1 (pt)
SK (1) SK287360B6 (pt)
TR (1) TR200200017T2 (pt)
UA (1) UA73310C2 (pt)
WO (1) WO2001004112A2 (pt)
ZA (1) ZA200201085B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006060597A1 (de) * 2006-12-21 2008-06-26 Merck Patent Gmbh Verfahren zur Herstellung von Benzofuran-2-carboxamiden
EP2110374A1 (en) * 2008-04-18 2009-10-21 Merck Sante Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators
RS53416B (sr) * 2009-03-10 2014-12-31 Takeda Pharmaceutical Company Limited Derivati benzofurana
CA2798610A1 (en) 2010-05-06 2011-11-10 Bristol-Myers Squibb Company Bicyclic heteroaryl compounds as gpr119 modulators
WO2011140161A1 (en) 2010-05-06 2011-11-10 Bristol-Myers Squibb Company Benzofuranyl analogues as gpr119 modulators
CN102964323B (zh) * 2012-11-13 2015-03-25 苏州永健生物医药有限公司 一种5-（哌嗪-1-基）苯并呋喃-2-甲酰胺的合成方法
EA028545B1 (ru) * 2013-06-10 2017-11-30 Астеллас Фарма Инк. Бициклическое азотсодержащее ароматическое гетероциклическое амидное соединение

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2724915A (en) * 1955-11-29 Snow remover
DE2757532A1 (de) * 1977-12-23 1979-07-05 Hoechst Ag N,n'-disubstituiertes cyclisches diamin und verfahren zu dessen herstellung
BR9406823A (pt) * 1993-06-14 1996-03-26 Pfizer Aminas secundárias e agentes anti-diabéticos e antiobesidade
DE4333254A1 (de) * 1993-09-30 1995-04-06 Merck Patent Gmbh Piperidine und Piperazine
DE19514567A1 (de) * 1995-04-20 1996-10-24 Merck Patent Gmbh Benzofurane

Also Published As

Publication number Publication date
BR0012329A (pt) 2002-03-19
ATE273973T1 (de) 2004-09-15
EP1194426B1 (de) 2004-08-18
CZ200211A3 (cs) 2002-04-17
HUP0201903A2 (en) 2002-10-28
JP2003504364A (ja) 2003-02-04
PL196477B1 (pl) 2008-01-31
HUP0201903A3 (en) 2005-02-28
ES2226884T3 (es) 2005-04-01
DE50007501D1 (de) 2004-09-23
AU767413B2 (en) 2003-11-06
WO2001004112A2 (de) 2001-01-18
HK1047275B (zh) 2005-09-02
CZ301441B6 (cs) 2010-03-03
WO2001004112A3 (de) 2001-08-02
KR100709378B1 (ko) 2007-04-20
SI1194426T1 (en) 2005-02-28
AR024671A1 (es) 2002-10-23
SK287360B6 (sk) 2010-08-09
PL353157A1 (en) 2003-10-20
CA2378603C (en) 2010-05-11
IL147494A0 (en) 2002-08-14
TR200200017T2 (tr) 2002-05-21
MY122667A (en) 2006-04-29
CN1178934C (zh) 2004-12-08
SK62002A3 (en) 2002-05-09
ZA200201085B (en) 2003-07-30
JP4908706B2 (ja) 2012-04-04
HK1047275A1 (en) 2003-02-14
NO20020095L (no) 2002-01-09
AU6266500A (en) 2001-01-30
NO20020095D0 (no) 2002-01-09
UA73310C2 (en) 2005-07-15
DE19932314A1 (de) 2001-01-11
CA2378603A1 (en) 2001-01-18
BR0012329B1 (pt) 2013-03-19
EP1194426A2 (de) 2002-04-10
CN1356996A (zh) 2002-07-03
RU2278862C2 (ru) 2006-06-27
HU229135B1 (en) 2013-08-28
PT1194426E (pt) 2005-01-31
MXPA02000316A (es) 2002-07-30
NO328209B1 (no) 2010-01-11
IL147494A (en) 2008-03-20
US6531503B1 (en) 2003-03-11
KR20020016815A (ko) 2002-03-06
DK1194426T3 (da) 2004-12-20

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 19/03/2013, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/06/2000 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 29/06/2020