BRPI0114510B8 - multímero de polipeptídeo monomérico purificado, composição de vacina para profilaxia ou tratamento da infecção por vírus da hepatite e em mamíferos, kit de diagnóstico para infecção por vírus da hepatite e em amostras biológicas, método de diagnóstico in vitro da infecção por vírus da hepatite e em mamíferos, método para detecção in vitro de anticorpos totais contra o vírus da hepatite e em amostras biológicas, método para detecção in vitro do anticorpo igg contra o vírus da hepatite e em amostras biológicas e método para detectar in vitro o anticorpo igm contra o vírus da hepatite e em amostras biológicas - Google Patents

multímero de polipeptídeo monomérico purificado, composição de vacina para profilaxia ou tratamento da infecção por vírus da hepatite e em mamíferos, kit de diagnóstico para infecção por vírus da hepatite e em amostras biológicas, método de diagnóstico in vitro da infecção por vírus da hepatite e em mamíferos, método para detecção in vitro de anticorpos totais contra o vírus da hepatite e em amostras biológicas, método para detecção in vitro do anticorpo igg contra o vírus da hepatite e em amostras biológicas e método para detectar in vitro o anticorpo igm contra o vírus da hepatite e em amostras biológicas

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Publication number
BRPI0114510B8
BRPI0114510B8 BRPI0114510A BRPI0114510B8 BR PI0114510 B8 BRPI0114510 B8 BR PI0114510B8 BR PI0114510 A BRPI0114510 A BR PI0114510A BR PI0114510 B8 BRPI0114510 B8 BR PI0114510B8
Authority
BR
Brazil
Prior art keywords
hepatitis virus
biological samples
virus infection
vitro detection
hepatitis
Prior art date
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Other languages
English (en)
Inventor
Zhang Jun
Xia Ningshao
Li Shaowei
Ge Shengxiang
Gu Ying
He Zhiqiang
Original Assignee
Beijing Wantai Biological Pharmacy Entpr Co Ltd
Yang Sheng Tang Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Beijing Wantai Biological Pharmacy Entpr Co Ltd, Yang Sheng Tang Co Ltd filed Critical Beijing Wantai Biological Pharmacy Entpr Co Ltd
Publication of BRPI0114510B1 publication Critical patent/BRPI0114510B1/pt
Publication of BRPI0114510B8 publication Critical patent/BRPI0114510B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6075—Viral proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/28011—Hepeviridae
    • C12N2770/28111—Hepevirus, e.g. hepatitis E virus
    • C12N2770/28122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/28011—Hepeviridae
    • C12N2770/28111—Hepevirus, e.g. hepatitis E virus
    • C12N2770/28134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/28011—Hepeviridae
    • C12N2770/28111—Hepevirus, e.g. hepatitis E virus
    • C12N2770/28171—Demonstrated in vivo effect

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"fragmentos de polipeptídeos do vírus da hepatite e, composição de vacina e kits de diagnóstico compreendendo o mesmo e uso destes". a presente invenção refere-se ao(s) polipeptídeo(s) compreendendo a seqüência de aminoácido apresentada na seq.id.no:1 da orf 2 do vírus da hepatite e ou seus fragmentos, o qual está na forma de polipeptídeo n-polimérico, onde n é um número inteiro de 1-180; uma proteína quimérica consistindo de um polipeptídeo da presente invenção e um fragmento conservado do antígeno hemaglutina do vírus influenza; um polipeptídeo da presente invenção ligado a um polipeptídeo contendo o epítopo da orf3 do vírus da hepatite e, ou um fragmento imunogênico do mesmo; um vetor de expressão recombinante compreendendo a molécula de dna codificando os polipeptídeos acima e a célula hospedeira transformada com o dito vetor de expressão recombinante que é capaz de expressar o polipeptídeo da presente invenção. a presente invenção refere-se adicionalmente a uma composição de vacina contra o vírus da hepatite e que compreende o polipeptídeo acima mencionado, ou kit de diagnóstico para infecção do vírus da hepatite e compreendendo o polipeptídeo acima mencionado, que inclui igg, igm, ou o kit de diagnóstico dos anticorpos totais para o vírus da hepatite e, e para o uso da composição da vacina e o kit de diagnóstico para profilaxia, diagnose e/ou tratamento da infecção por vírus da hepatite e.
BRPI0114510 2000-09-30 2001-09-30 multímero de polipeptídeo monomérico purificado, composição de vacina para profilaxia ou tratamento da infecção por vírus da hepatite e em mamíferos, kit de diagnóstico para infecção por vírus da hepatite e em amostras biológicas, método de diagnóstico in vitro da infecção por vírus da hepatite e em mamíferos, método para detecção in vitro de anticorpos totais contra o vírus da hepatite e em amostras biológicas, método para detecção in vitro do anticorpo igg contra o vírus da hepatite e em amostras biológicas e método para detectar in vitro o anticorpo igm contra o vírus da hepatite e em amostras biológicas BRPI0114510B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN00130634A CN1345775A (zh) 2000-09-30 2000-09-30 用于预防、诊断及治疗戊型肝炎病毒的多肽,及它们作为诊断试剂和疫苗
PCT/CN2001/001469 WO2002040681A1 (en) 2000-09-30 2001-09-30 The polypeptide fragments of hepatitis e virus, the vaccine composition comprising said fragments and the diagnostic kits

Publications (2)

Publication Number Publication Date
BRPI0114510B1 BRPI0114510B1 (pt) 2019-09-03
BRPI0114510B8 true BRPI0114510B8 (pt) 2021-05-25

Family

ID=4594225

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0114510 BRPI0114510B8 (pt) 2000-09-30 2001-09-30 multímero de polipeptídeo monomérico purificado, composição de vacina para profilaxia ou tratamento da infecção por vírus da hepatite e em mamíferos, kit de diagnóstico para infecção por vírus da hepatite e em amostras biológicas, método de diagnóstico in vitro da infecção por vírus da hepatite e em mamíferos, método para detecção in vitro de anticorpos totais contra o vírus da hepatite e em amostras biológicas, método para detecção in vitro do anticorpo igg contra o vírus da hepatite e em amostras biológicas e método para detectar in vitro o anticorpo igm contra o vírus da hepatite e em amostras biológicas
BR0114510-0A BR0114510A (pt) 2000-09-30 2001-09-30 Fragmentos de polipeptìdeos do vìrus da hepatite e, composição de vacina e kits de diagnóstico compreendendo o mesmo e uso destes

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BR0114510-0A BR0114510A (pt) 2000-09-30 2001-09-30 Fragmentos de polipeptìdeos do vìrus da hepatite e, composição de vacina e kits de diagnóstico compreendendo o mesmo e uso destes

Country Status (9)

Country Link
US (3) US7615228B2 (pt)
EP (2) EP2298793A3 (pt)
JP (3) JP5681337B2 (pt)
KR (2) KR100927221B1 (pt)
CN (2) CN101367869B (pt)
AU (1) AU2002220460A1 (pt)
BR (2) BRPI0114510B8 (pt)
MX (1) MXPA03002751A (pt)
WO (1) WO2002040681A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101367869B (zh) * 2000-09-30 2012-12-05 北京万泰生物药业股份有限公司 用于预防、诊断及治疗戊型肝炎病毒的多肽,及它们作为诊断试剂和疫苗
BR122015016384B8 (pt) 2001-11-08 2021-07-27 Beijing Wantai Biological Pharmacy Entpr Co Ltd polipeptídio recombinante ou isolado, molécula de ácido nucléico, kit de diagnóstico para detectar a infecção pelo vírus da hepatite e, composição de vacina, composição farmacêutica, vetor de expressão recombinante, célula hospedeira transformada e uso do polipeptídeo recombinante ou isolado
CN1850855B (zh) * 2006-05-26 2012-08-29 厦门大学 用于免疫或制备单克隆抗体的方法和组合物
US8906863B2 (en) 2009-02-27 2014-12-09 The Regents Of The University Of California Proteolysis-resistant capsid of chimeric hepatitis E virus as an oral delivery vector
US8906862B2 (en) 2009-02-27 2014-12-09 The Regents Of The University Of California Multiple antigen delivery system using hepatitis E virus-like particle
EP2400982B1 (en) * 2009-02-27 2016-05-11 The Regents of The University of California Multiple antigen delivery system using hepatitis e virus-like particle
CN103168277B (zh) * 2010-08-31 2016-06-08 Abb技术有限公司 用于调试包括多个子系统的过程或制造厂解决方案的方法
CN102453748A (zh) * 2010-10-18 2012-05-16 北京雅康博生物科技有限公司 用于荧光定量pcr定量检测的质粒标准品
CN102565410B (zh) * 2012-01-12 2014-08-06 吉林大学 一种梅花鹿朊蛋白免疫学检测方法
ES2900401T3 (es) * 2012-05-09 2022-03-16 Bharat Biotech Int Ltd Combinaciones de vacunas
CN104031144B (zh) * 2013-03-05 2017-08-25 厦门大学 特异结合戊型肝炎病毒3、4型的抗体及其用途
CN104789534B (zh) * 2015-04-10 2017-10-17 浙江中医药大学 一种杂交瘤、单克隆抗体及其用途
FR3044312B1 (fr) 2015-11-30 2017-12-08 Biomerieux Sa Polypeptides mutes de hev et leur utilisation pour le dosage d'anticorps anti-hev
BR112018074114A2 (pt) * 2016-05-25 2019-03-06 Intervet International B.V. vacina de hev
KR101924093B1 (ko) 2017-04-18 2018-11-30 건국대학교 산학협력단 E형 간염 바이러스 유전자형 3 및 4 진단용 프라이머 세트 및 이를 이용한 진단 방법
CN110501505B (zh) * 2018-05-18 2022-06-10 中国兽医药品监察所 小反刍兽疫诊断试剂盒
JP7454546B2 (ja) * 2018-07-10 2024-03-22 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Ｅ型肝炎ウイルスのＯＲＦ２ｉタンパク質に対して特異性を有する抗体及びその診断目的のための使用
WO2020011752A1 (en) * 2018-07-10 2020-01-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity for the orf2i protein of hepatitis e virus and uses thereof for diagnostic purposes
CN109942702B (zh) * 2019-03-20 2019-11-08 南京医科大学 一种人鼠嵌合抗HEV全分子IgG及其应用
CN117730255A (zh) 2021-07-06 2024-03-19 株式会社先端生命科学研究所 E型肝炎病毒感染的检测方法、e型肝炎病毒感染检测用抗原多肽和试剂盒
CN119390790B (zh) * 2024-12-05 2025-11-28 杭州旭科生物技术有限公司 一种检测戊肝病毒IgM的抗原和制备方法及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219515A (en) 1987-02-10 1989-09-27 Wellcome Found Fusion proteins comprising influenza virus ha and a nonnatural antigenic epitope
US5110730A (en) * 1987-03-31 1992-05-05 The Scripps Research Institute Human tissue factor related DNA segments
US6214970B1 (en) * 1988-06-17 2001-04-10 Genelabs Technologies, Inc. Hepatitis E virus antigens and uses therefor
US5885768A (en) 1988-06-17 1999-03-23 The United States Of America As Represented By The Department Of Health And Human Services Hepatitis E virus peptide antigen and antibodies
US5714374A (en) * 1990-09-12 1998-02-03 Rutgers University Chimeric rhinoviruses
WO1996010580A2 (en) * 1994-10-03 1996-04-11 The Government Of The United States Of America, Re Recombinant proteins of a pakistani strain of hepatitis e and their use in diagnostic methods and vaccines
US5563032A (en) * 1992-10-21 1996-10-08 The United States Of America As Represented By The Department Of Health And Human Services Mosaic polypeptide and methods for detecting the hepatitis E virus
EP0736087A1 (en) 1993-12-22 1996-10-09 Abbott Laboratories Monoclonal antibodies against hev orf-2 and methods for using same
AUPN443995A0 (en) * 1995-07-27 1995-08-17 Csl Limited Papillomavirus polyprotein
US6054567A (en) 1997-04-11 2000-04-25 The United States Of America As Represented By The Department Of Health And Human Services Recombinant proteins of a pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
DE19830896A1 (de) * 1998-07-10 2000-06-08 Mivatec Gmbh Fotoplott-Verfahren zur hochenergetischen Aufzeichnung eines computergespeicherten Rasterbildes auf einen lichtempfindlichen Aufzeichnungsträger
US6045567A (en) * 1999-02-23 2000-04-04 Lifescan Inc. Lancing device causing reduced pain
CA2283538A1 (en) * 1999-09-30 2001-03-30 Mun Hon Ng New hev antigenic peptide and methods
CN101367869B (zh) * 2000-09-30 2012-12-05 北京万泰生物药业股份有限公司 用于预防、诊断及治疗戊型肝炎病毒的多肽,及它们作为诊断试剂和疫苗

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CN1345775A (zh) 2002-04-24
KR100927221B1 (ko) 2009-11-16
JP5829830B2 (ja) 2015-12-09
US20040052813A1 (en) 2004-03-18
EP1331271B1 (en) 2014-03-19
MXPA03002751A (es) 2004-05-04
JP5681337B2 (ja) 2015-03-04
EP1331271A1 (en) 2003-07-30
EP1331271A4 (en) 2005-04-06
AU2002220460A1 (en) 2002-05-27
JP2014138593A (ja) 2014-07-31
BR0114510A (pt) 2004-02-17
KR101121754B1 (ko) 2012-03-23
US8524868B2 (en) 2013-09-03
KR20090088429A (ko) 2009-08-19
CN101367869A (zh) 2009-02-18
EP2298793A2 (en) 2011-03-23
JP2011201881A (ja) 2011-10-13
US7615228B2 (en) 2009-11-10
CN101367869B (zh) 2012-12-05
WO2002040681A1 (en) 2002-05-23
US20100143410A1 (en) 2010-06-10
BRPI0114510B1 (pt) 2019-09-03
EP2298793A3 (en) 2011-06-29
US8715695B2 (en) 2014-05-06
JP2004525613A (ja) 2004-08-26
KR20030048052A (ko) 2003-06-18
US20100150962A1 (en) 2010-06-17

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