BRPI0300644B8 - Processo de preparação de biosilicatos particulados, bioativos e reabsorvíveis, composições para preparar ditos biosilicatos e biosilicatos particulados bioativos e reabsorvíveis. - Google Patents

Processo de preparação de biosilicatos particulados, bioativos e reabsorvíveis, composições para preparar ditos biosilicatos e biosilicatos particulados bioativos e reabsorvíveis.

Info

Publication number
BRPI0300644B8
BRPI0300644B8 BRPI0300644A BR0300644A BRPI0300644B8 BR PI0300644 B8 BRPI0300644 B8 BR PI0300644B8 BR PI0300644 A BRPI0300644 A BR PI0300644A BR 0300644 A BR0300644 A BR 0300644A BR PI0300644 B8 BRPI0300644 B8 BR PI0300644B8
Authority
BR
Brazil
Prior art keywords
bioactive
resorbable
biosilicates
preparing
particulate
Prior art date
Application number
BRPI0300644A
Other languages
English (en)
Other versions
BR0300644B1 (pt
BR0300644A (pt
Inventor
Christian Ravagnani
Dutra Zanotto Edgar
Helena Guimarães Lara Elza
Heitor Panzeri
Peitl Filho Oscar
Original Assignee
Fundacao Univ Federal De Sao Carlos
Univ Sao Paulo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacao Univ Federal De Sao Carlos, Univ Sao Paulo filed Critical Fundacao Univ Federal De Sao Carlos
Priority to BRPI0300644A priority Critical patent/BRPI0300644B8/pt
Priority to CNB2004800081963A priority patent/CN100506730C/zh
Priority to DE602004005834T priority patent/DE602004005834D1/de
Priority to KR1020057015396A priority patent/KR101161252B1/ko
Priority to AT04712976T priority patent/ATE359241T1/de
Priority to JP2006501393A priority patent/JP2006519776A/ja
Priority to RU2005126460/03A priority patent/RU2353594C2/ru
Priority to PCT/BR2004/000015 priority patent/WO2004074199A1/en
Priority to US10/546,365 priority patent/US20060251737A1/en
Priority to EP04712976A priority patent/EP1601623B1/en
Publication of BR0300644A publication Critical patent/BR0300644A/pt
Publication of BR0300644B1 publication Critical patent/BR0300644B1/pt
Publication of BRPI0300644B8 publication Critical patent/BRPI0300644B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
    • A61K6/69—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
    • A61K6/836—Glass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C10/00—Devitrified glass ceramics, i.e. glass ceramics having a crystalline phase dispersed in a glassy phase and constituting at least 50% by weight of the total composition
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C4/00—Compositions for glass with special properties
    • C03C4/0007—Compositions for glass with special properties for biologically-compatible glass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C12/00—Powdered glass; Bead compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Ceramic Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dental Preparations (AREA)
  • Glass Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Re-Forming, After-Treatment, Cutting And Transporting Of Glass Products (AREA)

Abstract

"processo de preparação de biosilicatos particulados bioativos e reabsorvíveis, composições para preparar ditos biosilicatos, biosilicatos particulados bioativos e reabsorvíveis e uso dos mesmos no tratamento de afecções bucais". é descrito um processo de preparação de biosilicatos particulados, bioativos e reabsorvíveis a partir de placas ou fritas de vidro, que compreende tratar termicamente as placas ou fritas de vidro em uma única ou duas etapas de tratamento térmico, em temperaturas e tempos controlados e em seguida moer o vidro cristalizado para obter o pó de produto biosilicato cristalino desejado, bioativo e reabsorvível isento de superfícies cortantes, que em contato com os fluidos corpóreos produza uma camada de hidroxicarbonatoapatita restauradora dos dentes ou seja gradativamente substituído pelo tecido dental e reabsorvido. alternativamente, inicialmente é obtido o pó que é então tratado termicamente para produzir o pó cristalino, bioativo e reabsorvível isento de superficies cortantes. para diferentes condições de processo, diferentes fases cristalinas são obtidas, de modo que é possível obter uma variada gama de silicatos bioativos ou reabsorviveis que podem ser usados isolados ou combinados, com aplicação para o tratamento de diferentes afecções bucais como hiper sensibilidade da dentina, fissuras dentárias e xerostomia. o biosilicato tem granulometria entre 0,1 e 30 micra.
BRPI0300644A 2003-02-20 2003-02-20 Processo de preparação de biosilicatos particulados, bioativos e reabsorvíveis, composições para preparar ditos biosilicatos e biosilicatos particulados bioativos e reabsorvíveis. BRPI0300644B8 (pt)

Priority Applications (10)

Application Number Priority Date Filing Date Title
BRPI0300644A BRPI0300644B8 (pt) 2003-02-20 2003-02-20 Processo de preparação de biosilicatos particulados, bioativos e reabsorvíveis, composições para preparar ditos biosilicatos e biosilicatos particulados bioativos e reabsorvíveis.
CNB2004800081963A CN100506730C (zh) 2003-02-20 2004-02-20 制备用于口腔疾病治疗的粒状、生物活性或可再吸收的生物硅酸盐的方法和组合物
DE602004005834T DE602004005834D1 (de) 2003-02-20 2004-02-20 Verfahren und zusammensetzungen zur herstellung von teilchenförmigen, bioaktiven oder resorbierbaren biosilikaten zur verwendung bei der behandlung von mundbeschwerden
KR1020057015396A KR101161252B1 (ko) 2003-02-20 2004-02-20 구강 질환 치료에 이용되는 생체활성 또는 재흡수성바이오실리케이트 미립자의 제조방법 및 그 조성물
AT04712976T ATE359241T1 (de) 2003-02-20 2004-02-20 Verfahren und zusammensetzungen zur herstellung von teilchenförmigen, bioaktiven oder resorbierbaren biosilikaten zur verwendung bei der behandlung von mundbeschwerden
JP2006501393A JP2006519776A (ja) 2003-02-20 2004-02-20 口腔疾患の治療のための粒状の生物学的に活性な又は再吸収性のバイオシリケートの製造方法及び組成物
RU2005126460/03A RU2353594C2 (ru) 2003-02-20 2004-02-20 Способ и композиция для получения дисперсных, биоактивных или рассасывающихся биосиликатов для применения в лечении заболеваний ротовой полости
PCT/BR2004/000015 WO2004074199A1 (en) 2003-02-20 2004-02-20 Process and compositions for preparing particulate, bioactive or resorbable biosilicates for use in the treatment of oral ailments
US10/546,365 US20060251737A1 (en) 2003-02-20 2004-02-20 Process and compositions for preparing particulate, bioactive or resorbable biosilicates for use in the treatment of oral ailments
EP04712976A EP1601623B1 (en) 2003-02-20 2004-02-20 Process and compositions for preparing particulate, bioactive or resorbable biosilicates for use in the treatment of oral ailments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0300644A BRPI0300644B8 (pt) 2003-02-20 2003-02-20 Processo de preparação de biosilicatos particulados, bioativos e reabsorvíveis, composições para preparar ditos biosilicatos e biosilicatos particulados bioativos e reabsorvíveis.

Publications (3)

Publication Number Publication Date
BR0300644A BR0300644A (pt) 2004-11-16
BR0300644B1 BR0300644B1 (pt) 2012-08-21
BRPI0300644B8 true BRPI0300644B8 (pt) 2022-04-26

Family

ID=36751905

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0300644A BRPI0300644B8 (pt) 2003-02-20 2003-02-20 Processo de preparação de biosilicatos particulados, bioativos e reabsorvíveis, composições para preparar ditos biosilicatos e biosilicatos particulados bioativos e reabsorvíveis.

Country Status (10)

Country Link
US (1) US20060251737A1 (pt)
EP (1) EP1601623B1 (pt)
JP (1) JP2006519776A (pt)
KR (1) KR101161252B1 (pt)
CN (1) CN100506730C (pt)
AT (1) ATE359241T1 (pt)
BR (1) BRPI0300644B8 (pt)
DE (1) DE602004005834D1 (pt)
RU (1) RU2353594C2 (pt)
WO (1) WO2004074199A1 (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070254260A1 (en) * 2005-12-02 2007-11-01 Alden Wayne S Iv Oral care compositions, methods, devices and systems
US20100015068A1 (en) * 2006-07-06 2010-01-21 Massachusetts Institute Of Technology Methods and Compositions For Altering Biological Surfaces
US20080268001A1 (en) * 2007-04-30 2008-10-30 Lynette Zaidel Oral care composition to reduce or eliminate dental sensitivity
US20090186090A1 (en) * 2007-04-30 2009-07-23 Colgate-Palmolive Oral Care Composition to Reduce or Eliminate Dental Sensitivity
US20080267891A1 (en) * 2007-04-30 2008-10-30 Colgate-Palmolive Company Oral Care Composition To Reduce Or Eliminate Dental Sensitivity
US20090317339A1 (en) * 2008-06-23 2009-12-24 Deepak Sharma Teeth Bleaching Compositions and Devices
CA2760130C (en) 2009-05-18 2016-11-08 Colgate-Palmolive Company Oral compositions containing polyguanidinium compounds and methods of manufacture and use thereof
TWI499430B (zh) 2009-12-17 2015-09-11 美國棕欖公司 抗侵蝕的牙膏組成物
SG182316A1 (en) 2010-01-29 2012-08-30 Colgate Palmolive Co Oral care product for sensitive enamel care
CN102258432B (zh) * 2010-05-31 2012-11-21 常州倍尔生生物科技有限公司 pH缓冲生物活性玻璃及其制备方法和防治口腔疾病的用途
JP5603207B2 (ja) * 2010-11-08 2014-10-08 湖州大享玻璃制品有限公司 結晶化ガラスの連続成形方法および結晶化ガラスの連続成形装置
CN103458903B (zh) * 2011-01-28 2017-07-04 Abk生物医学公司 不透射线的栓塞颗粒
PT105617A (pt) * 2011-04-05 2012-10-08 Univ Aveiro Composição de vidros bioactivos, sua utilização e respectivo método de obtenção
DE102012203875A1 (de) * 2011-04-21 2012-10-25 Schott Ag Glaspulver mit verbesserter Korngrößenverteilung und Verfahren zu dessen Herstellung
CN102862985B (zh) * 2012-10-23 2016-01-20 徐阳波 一种可水解磷硅酸钾钙活性材料的制备及其应用
CN103239476A (zh) * 2013-05-23 2013-08-14 关晴光 涑爽生物活性矿物质粉及其制备方法和应用
BR102013020961A2 (pt) 2013-08-12 2016-03-08 Univ Fed De São Carlos composição vítrea, fibras e tecidos vítreos bioativos e artigos
CN103992037B (zh) * 2014-05-30 2016-08-24 苏州大学 多孔高硼硅酸盐及其制备方法
US11083806B2 (en) 2014-11-26 2021-08-10 Abk Biomedical Incorporated Radioembolic particles
CN105277417A (zh) * 2015-11-27 2016-01-27 新疆医科大学 简易牙齿扫描电镜样品的制备方法
KR101975548B1 (ko) * 2017-03-07 2019-05-08 주식회사 하스 열처리 온도의 변화로 가공성 또는 투광성 조절이 가능한 결정화 유리 제조 방법
CN107235634A (zh) * 2017-07-06 2017-10-10 江西草珊瑚口腔护理用品有限公司 一种生物活性玻璃陶瓷材料及其制备方法和一种牙膏
CN109399943B (zh) * 2018-11-16 2021-07-09 杭州纳美智康科技有限公司 生物活性玻璃及其制备方法、微晶玻璃及制备方法和应用
EP3887331B1 (en) * 2018-11-26 2024-08-14 Corning Incorporated Bioactive silicate glasses
RU2731434C1 (ru) * 2019-12-27 2020-09-02 Автономная некоммерческая организация высшего образования «Белгородский университет кооперации, экономики и права» Способ получения фритты
BR102020017697A2 (pt) * 2020-08-31 2022-03-15 Fundação Universidade Federal De São Carlos Processo de preparação de enxertos ósseos e enxertos ósseos obtidos
CN113749955B (zh) * 2021-09-28 2022-09-09 中南大学 一种具有再矿化能力的牙啫喱、牙贴及牙啫喱的制备方法
CN114790083B (zh) * 2022-05-05 2023-09-05 山东国瓷功能材料股份有限公司 玻璃陶瓷及其制备方法和应用
CN120136451B (zh) * 2025-03-13 2025-11-18 西北有色金属研究院 一种提高生物活性玻璃纳米颗粒降解速率的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69731184T2 (de) * 1996-01-29 2005-10-13 University Of Maryland, Baltimore Bioaktive glaszusammensetzungen zur verwendung zur behandlung von zahnstrukturen
JP4180657B2 (ja) * 1996-01-29 2008-11-12 ユニバーシティ オブ メリーランド、バルティモア 生理活性ガラス組成物
US5735942A (en) * 1996-02-07 1998-04-07 Usbiomaterials Corporation Compositions containing bioactive glass and their use in treating tooth hypersensitivity
JP3457680B2 (ja) * 1996-05-01 2003-10-20 ユーエスバイオマテリアルズ コーポレイション 生物活性セラミックス及び生物活性セラミックスの製造方法
US6190643B1 (en) * 1999-03-02 2001-02-20 Patricia Stoor Method for reducing the viability of detrimental oral microorganisms in an individual, and for prevention and/or treatment of diseases caused by such microorganisms; and whitening and/or cleaning of an individual's teeth
US6436370B1 (en) 1999-06-23 2002-08-20 The Research Foundation Of State University Of New York Dental anti-hypersensitivity composition and method
US6787584B2 (en) * 2000-08-11 2004-09-07 Pentron Corporation Dental/medical compositions comprising degradable polymers and methods of manufacture thereof
DE10111449A1 (de) * 2001-03-09 2002-09-26 Schott Glas Verwendung von bioaktivem Glas in Zahnfüllmaterial

Also Published As

Publication number Publication date
BR0300644B1 (pt) 2012-08-21
ATE359241T1 (de) 2007-05-15
JP2006519776A (ja) 2006-08-31
CN1771208A (zh) 2006-05-10
RU2353594C2 (ru) 2009-04-27
WO2004074199A1 (en) 2004-09-02
EP1601623B1 (en) 2007-04-11
EP1601623A1 (en) 2005-12-07
US20060251737A1 (en) 2006-11-09
KR20060010719A (ko) 2006-02-02
DE602004005834D1 (de) 2007-05-24
BR0300644A (pt) 2004-11-16
KR101161252B1 (ko) 2012-07-02
CN100506730C (zh) 2009-07-01

Similar Documents

Publication Publication Date Title
BRPI0300644B8 (pt) Processo de preparação de biosilicatos particulados, bioativos e reabsorvíveis, composições para preparar ditos biosilicatos e biosilicatos particulados bioativos e reabsorvíveis.
Zhao et al. Bond strength of primer/cement systems to zirconia subjected to artificial aging
Gjorgievska et al. Prevention of enamel demineralization after tooth bleaching by bioactive glass incorporated into toothpaste
Ying et al. Effect of Er: YAG laser and organic matrix on porosity changes in human enamel
Mitchell et al. Biomimetic dentin desensitizer based on nano-structured bioactive glass
Feldon et al. Diode laser debonding of ceramic brackets
Dionysopoulos et al. Effect of Er, Cr: YSGG laser irradiation on bovine enamel surface during in-office tooth bleaching ex vivo
Mirhashemi et al. Evaluation of different types of lasers in surface conditioning of porcelains: a review article
Lee et al. Bioactive glass and high‐intensity lasers as a promising treatment for dentin hypersensitivity: An in vitro study
Moradabadi et al. Effects of surface treatment on bond strength between dental resin agent and zirconia ceramic
BRPI0518578A2 (pt) combinaÇço de gel/sÍlica precipitada produzida in situ, formulaÇço de dentifrÍcio, e, mÉtodo de produzir a combinaÇço
Selvig et al. Effect of stannous fluoride and tetracycline on periodontal repair after delayed tooth replantation in dogs
Dong et al. Tricalcium silicate induced mineralization for occlusion of dentinal tubules
Wang et al. Use of poly (amidoamine) dendrimer for dentinal tubule occlusion: a preliminary study
Augusto et al. Bond stability of a universal adhesive system to eroded/abraded dentin after deproteinization
Chandru et al. Comparative evaluation of three different toothpastes on remineralization potential of initial enamel lesions: A scanning electron microscopic study
Garma et al. Development of a remineralizing calcium phosphate nanoparticle-containing self-etching system for orthodontic bonding
BRPI0517899A (pt) método para produzir uma combinação de gel/sìlica precipitada produzida in situ, combinação de gel/sìlica precipitada produzida in situ, e, dentifrìcio
Kasakawa et al. Effect of Q-switched Er: YAG laser irradiation on bonding performance to dentin surface
Behroozibakhsh et al. Evaluation of crystalline changes and resistance to demineralization of the surface of human dental enamel treated with Er: YAG laser and fluoride using x-ray diffraction analysis and Vickers microhardness
Dewi et al. Remineralizing potential of natural hydroxyapatite from snakehead (Channa striata) fish bone on remineralization of primary teeth enamel: an in vitro study
US9795540B2 (en) Removable adhesion material
Huang et al. The effects of 45S5 bioactive glass and Er: YAG Laser on the microtensile bond strength of fluorosed teeth
Liu et al. Effect of Er: YAG laser and plasma treatment on the bond strength of Y-TZP
Sinhoreti et al. Effect of Bioglass 45S5 air-abrasion on dentin bonding: evaluation of microtensile bond strength and confocal microscopy

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09S Decision of refusal: publication cancelled [chapter 9.2.2 patent gazette]

Free format text: REFERENTE A RPI 2093 DE 15/02/2011.

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/02/2003, OBSERVADAS AS CONDICOES LEGAIS.

B15K Others concerning applications: alteration of classification

Ipc: A61Q 11/00 (2006.01), A61K 6/00 (2006.01), A61K 6/

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REF. RPI 2172 DE 21/08/2012 QUANTO AO TITULAR.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 20/02/2023