BRPI0315652B8 - molécula de ácido nucleico isolada, vetor, polipeptídeo de fusão, e, multímero - Google Patents

molécula de ácido nucleico isolada, vetor, polipeptídeo de fusão, e, multímero

Info

Publication number
BRPI0315652B8
BRPI0315652B8 BRPI0315652A BR0315652A BRPI0315652B8 BR PI0315652 B8 BRPI0315652 B8 BR PI0315652B8 BR PI0315652 A BRPI0315652 A BR PI0315652A BR 0315652 A BR0315652 A BR 0315652A BR PI0315652 B8 BRPI0315652 B8 BR PI0315652B8
Authority
BR
Brazil
Prior art keywords
fusion polypeptide
nucleic acid
vector
isolated nucleic
multimer
Prior art date
Application number
BRPI0315652A
Other languages
English (en)
Other versions
BRPI0315652B1 (pt
BR0315652A (pt
Inventor
D Yancopoulos George
Stahl Neil
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of BR0315652A publication Critical patent/BR0315652A/pt
Publication of BRPI0315652B1 publication Critical patent/BRPI0315652B1/pt
Publication of BRPI0315652B8 publication Critical patent/BRPI0315652B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Sewing Machines And Sewing (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Vehicle Body Suspensions (AREA)

Abstract

"molécula de ácido nucleico isolada, vetor sistema de vetor-hospedeiro, método de produção de um polipeptídeo de fusão, ácido nucleico isolado, polipeptídeo de fusão, e, multímero". a presente invenção proporciona um polipeptídeo de fusão capaz de se ligar em interleucina-1 (il-1) para formar um complexo não funcional. também proporciona uma sequência de ácido nucleico codificadora do polipeptídeo de fusão e métodos de preparação e usos do polipeptídeo de fusão.
BRPI0315652A 2002-10-28 2003-10-24 molécula de ácido nucleico isolada, vetor, polipeptídeo de fusão, e, multímero BRPI0315652B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/282,162 2002-10-28
US10/282,162 US6927044B2 (en) 1998-09-25 2002-10-28 IL-1 receptor based cytokine traps
PCT/US2003/033718 WO2004039951A2 (en) 2002-10-28 2003-10-24 Il-1 receptor based antagonists and methods of making and using

Publications (3)

Publication Number Publication Date
BR0315652A BR0315652A (pt) 2005-08-30
BRPI0315652B1 BRPI0315652B1 (pt) 2018-02-06
BRPI0315652B8 true BRPI0315652B8 (pt) 2021-05-25

Family

ID=32228782

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0315652A BRPI0315652B8 (pt) 2002-10-28 2003-10-24 molécula de ácido nucleico isolada, vetor, polipeptídeo de fusão, e, multímero

Country Status (18)

Country Link
US (4) US6927044B2 (pt)
EP (1) EP1572967B1 (pt)
JP (1) JP4387309B2 (pt)
CN (1) CN1878871B (pt)
AT (1) ATE420970T1 (pt)
AU (1) AU2003284895B2 (pt)
BR (1) BRPI0315652B8 (pt)
CA (1) CA2502385C (pt)
CY (2) CY1110675T1 (pt)
DE (1) DE60325892D1 (pt)
DK (1) DK1572967T3 (pt)
ES (1) ES2320338T3 (pt)
IL (1) IL168050A (pt)
LU (1) LU91680I2 (pt)
MX (1) MXPA05004333A (pt)
PT (1) PT1572967E (pt)
SI (1) SI1572967T1 (pt)
WO (1) WO2004039951A2 (pt)

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