BRPI0407276A - fatty acids, glycerides and analogues of medium chain length as erythropoiesis stimulants - Google Patents

fatty acids, glycerides and analogues of medium chain length as erythropoiesis stimulants

Info

Publication number
BRPI0407276A
BRPI0407276A BR0407276-6A BRPI0407276A BRPI0407276A BR PI0407276 A BRPI0407276 A BR PI0407276A BR PI0407276 A BRPI0407276 A BR PI0407276A BR PI0407276 A BRPI0407276 A BR PI0407276A
Authority
BR
Brazil
Prior art keywords
glycerides
fatty acids
chain length
medium chain
analogues
Prior art date
Application number
BR0407276-6A
Other languages
Portuguese (pt)
Inventor
Christopher Penney
Lyne Gagnon
Pierre Laurin
Boulos Zacharie
Original Assignee
Prometic Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prometic Biosciences Inc filed Critical Prometic Biosciences Inc
Publication of BRPI0407276A publication Critical patent/BRPI0407276A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"áCIDOS GRAXOS, GLICERìDEOS E ANáLOGOS COM COMPRIMENTO DE CADEIA MéDIO COMO ESTIMULANTES DA ERITROPOIESE". Uso de uma composição compreendendo um composto de qualquer uma das fórmulas I, II, IIa, III e IIIa, ou uma combinação dessas, sendo que cada R~ 1~ é independentemente alquila C~ 7~ a C~ 11~, A e B são independentemente H ou CO-R~ 1~, R~ 2~ é H ou alquila C~ 1~ a C~ 4~, M é um cátion monovalente (k = 1) ou cátion divalente (k = 2) de metal, Y é O ou NH e Z é O, NH, CH~ 2~O ou uma ligação; para a produção de um medicamento para estimular a eritropoiese. De preferência, a composição compreende adicionalmente eritropoietina humana."FATTY ACIDS, GLYCERIDES AND ANALOGS WITH MEDIUM CHAIN LENGTH AS ERYTHROPOIESE STIMULANTS". Use of a composition comprising a compound of any one of formulas I, II, IIa, III and IIIa, or a combination thereof, wherein each R 1 is independently C 7 to C 11, A and B alkyl. are independently H or CO-R 1 ~, R 2 is H or C 1-1 alkyl to C 4-4, M is a monovalent cation (k = 1) or divalent metal cation (k = 2), Y is O or NH and Z is O, NH, CH 2 -O or a bond; for the production of a drug to stimulate erythropoiesis. Preferably, the composition further comprises human erythropoietin.

BR0407276-6A 2003-02-07 2004-02-06 fatty acids, glycerides and analogues of medium chain length as erythropoiesis stimulants BRPI0407276A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44545403P 2003-02-07 2003-02-07
PCT/GB2004/000457 WO2004069237A1 (en) 2003-02-07 2004-02-06 Medium-chain length fatty acids, glycerides and analogues as stimulators of erythropoiesis

Publications (1)

Publication Number Publication Date
BRPI0407276A true BRPI0407276A (en) 2006-01-31

Family

ID=32850990

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0407276-6A BRPI0407276A (en) 2003-02-07 2004-02-06 fatty acids, glycerides and analogues of medium chain length as erythropoiesis stimulants

Country Status (28)

Country Link
US (1) US9682054B2 (en)
EP (1) EP1592416B1 (en)
JP (1) JP5390070B2 (en)
KR (1) KR101120775B1 (en)
CN (1) CN100427081C (en)
AP (1) AP2005003367A0 (en)
AR (1) AR043120A1 (en)
AT (1) ATE419846T1 (en)
AU (1) AU2004210193B2 (en)
BR (1) BRPI0407276A (en)
CA (1) CA2515160C (en)
CY (1) CY1108963T1 (en)
DE (2) DE04708802T1 (en)
DK (1) DK1592416T3 (en)
EA (1) EA009939B1 (en)
ES (1) ES2255467T3 (en)
IL (1) IL170057A (en)
JO (1) JO2705B1 (en)
MA (1) MA27664A1 (en)
MX (1) MXPA05008382A (en)
MY (1) MY140913A (en)
NO (1) NO334085B1 (en)
NZ (1) NZ541593A (en)
PT (1) PT1592416E (en)
SI (1) SI1592416T1 (en)
TN (1) TNSN05189A1 (en)
WO (1) WO2004069237A1 (en)
ZA (1) ZA200506246B (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL158322A0 (en) * 2001-04-18 2004-05-12 Prometic Biosciences Inc Medium-chain length fatty acids, glycerides and analogues as neutrophil survival and activation factors
US8241670B2 (en) * 2004-04-15 2012-08-14 Chiasma Inc. Compositions capable of facilitating penetration across a biological barrier
US20070219131A1 (en) * 2004-04-15 2007-09-20 Ben-Sasson Shmuel A Compositions capable of facilitating penetration across a biological barrier
EP1771470B1 (en) 2004-07-23 2013-06-26 Acceleron Pharma Inc. Actrii receptor polypeptides, methods and compositions
KR20070063507A (en) * 2004-09-03 2007-06-19 프로메틱 바이오사이언시즈 인코포레이티드 Substituted purinyl derivatives with immunomodulator and chemoprotective activity and use alone or with medium-chain length fatty acids or glycerides
US8071580B2 (en) * 2004-10-01 2011-12-06 Prometic Biosciences Inc. Medium-chain length fatty alcohols as stimulators of hematopoiesis
MX2007003967A (en) * 2004-10-01 2008-03-04 Prometic Biosciences Inc Medium-chain length fatty alcohols as stimulators of hematopoiesis.
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
KR20190006086A (en) 2005-11-23 2019-01-16 악셀레론 파마 인코포레이티드 Activin-actrπa antagonists and uses for promoting bone growth
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
EP2111229B1 (en) 2007-02-01 2013-04-10 Acceleron Pharma, Inc. Pharmaceutical compositions comprising Activin-ActRIIA antagonists for use in preventing or treating breast cancer metastasis or breast cancer related bone loss
TWI782836B (en) 2007-02-02 2022-11-01 美商艾瑟勒朗法瑪公司 Variants derived from actriib and uses therefor
ES2756725T3 (en) 2007-02-09 2020-04-27 Acceleron Pharma Inc Pharmaceutical compositions comprising Activin-ActRIIA antagonists
EP3243524A1 (en) 2007-09-18 2017-11-15 Acceleron Pharma Inc. Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion
CN101878028A (en) 2007-11-02 2010-11-03 普罗米蒂克生物科学公司 Medium-chain-length fatty acids and glycerides as nephroprotectants
NZ586249A (en) * 2007-12-19 2012-05-25 Prometic Biosciences Inc A combination of medium-chain length fatty acids, salts or triglycerides, gemcitabine, and optionally erlotinib, for the treatment of pancreatic cancer
SMT202300222T1 (en) 2008-08-14 2023-09-06 Acceleron Pharma Inc Gdf traps
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
CN102176900B (en) 2008-09-17 2017-09-26 克艾思马有限公司 Pharmaceutical compositions and related administration methods
BRPI1010587A2 (en) 2009-06-08 2019-04-09 Acceleron Pharma Inc. Methods to Increase Thermogenic Adipocytes
EP2440577A4 (en) 2009-06-12 2013-01-23 Acceleron Pharma Inc ACTRIIB-FC TRUNCATED FUSION PROTEINS
KR20180085825A (en) * 2009-08-13 2018-07-27 악셀레론 파마 인코포레이티드 Combined use of gdf traps and erythropoietin receptor activators to increase red blood cell levels
JP6267425B2 (en) 2009-11-17 2018-01-24 アクセルロン ファーマ， インコーポレイテッド ACTRIIB protein and its variants and uses thereof for utrophin induction for the treatment of muscular dystrophy
CN103298832A (en) 2010-11-08 2013-09-11 阿塞勒隆制药公司 ACTRIIA binding agents and uses thereof
TWI572352B (en) * 2012-03-01 2017-03-01 波麥堤克藥學Ｓｍｔ有限公司 Method for the preparation of triglycerides of medium-chain length fatty acids
NZ707477A (en) 2012-11-02 2019-09-27 Celgene Corp Activin-actrii antagonists and uses for treating bone and other disorders
CN102973922B (en) * 2012-12-18 2016-02-03 华东理工大学 A kind of application of fusion rotein
WO2015192111A1 (en) 2014-06-13 2015-12-17 Acceleron Pharma, Inc. Methods and compositions for treating ulcers
MA41052A (en) 2014-10-09 2017-08-15 Celgene Corp TREATMENT OF CARDIOVASCULAR DISEASE USING ACTRII LIGAND TRAPS
JP2018501307A (en) 2014-12-03 2018-01-18 セルジーン コーポレイション Activin-ActRII antagonist and use for treating anemia
HUE071943T2 (en) 2015-02-03 2025-10-28 Amryt Endo Inc Treatment of acromegaly with oral octreotide
US20170021029A1 (en) * 2015-04-15 2017-01-26 Jeffrey Charles Raber Topical formulations and uses
MA53188A1 (en) 2018-10-11 2021-12-31 Basf As Aromatic compounds and their pharmaceutical uses
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4871768A (en) * 1984-07-12 1989-10-03 New England Deaconess Hospital Corporation Dietary supplement utilizing ω-3/medium chain trigylceride mixtures
US7307166B1 (en) * 1987-10-28 2007-12-11 Wellstat Therapeutics Corporation Oxpurine nucleosides and their congeners, and acyl, derivatives thereof, for improvement of hematopoiesis
US5011852A (en) * 1988-07-25 1991-04-30 Applied Analytical Industries, Inc. Liquid oral pharmaceutical compositions of non-steroidal anti-inflammatory drugs
JP3014119B2 (en) * 1990-05-28 2000-02-28 雪印乳業株式会社 Erythropoietic agents for rectal administration
JP3249147B2 (en) 1990-06-01 2002-01-21 キリン−アムジエン・インコーポレーテツド Oral preparation containing bioactive protein
EP0495187B1 (en) * 1991-01-15 1997-01-22 Hemosphere, Inc. Protein nanomatrixes and method of production
JPH05163160A (en) * 1991-12-13 1993-06-29 Snow Brand Milk Prod Co Ltd Nutritional supplement for prevention and treatment of infectious diseases associated with immunity decline
US5214035A (en) * 1992-04-16 1993-05-25 Hoechst-Roussel Agri-Vet Company Thixotropic formulations
US5318781A (en) * 1993-04-06 1994-06-07 Hoffmann-La Roche Inc. Absorption enhancement of antibiotics
US20010003739A1 (en) * 1993-06-24 2001-06-14 Astrazeneca Ab Systemic administration of a therapeutic preparation
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
AU7082694A (en) * 1994-05-10 1995-11-29 Kitasato Institute, The Hematopoietic stem cell proliferation accelerator
US5470861A (en) * 1994-08-04 1995-11-28 Hoffmann-La Roche Inc. Method of promoting hair growth
US5549905A (en) * 1994-10-18 1996-08-27 Clintec Nutrition Co. Enternal composition for pediatric patients
JPH08208510A (en) 1994-11-03 1996-08-13 F Hoffmann La Roche Ag Interferon composition
GB9516268D0 (en) 1995-08-08 1995-10-11 Danbiosyst Uk Compositiion for enhanced uptake of polar drugs from the colon
AUPN933396A0 (en) * 1996-04-17 1996-05-09 Pfizer Pty Limited Non-aqueuos oral-drench compositions containing avermectin compounds
US5851534A (en) 1996-05-03 1998-12-22 Dynagen, Inc. Methods for prevention and/or treatment of neutropenia
JPH10265380A (en) * 1997-03-17 1998-10-06 Bristol Myers Squibb Co Anticancer agent
AU9221698A (en) * 1997-09-04 1999-03-22 Biozone Laboratories, Inc. Oral liposomal delivery system
EP1030652B1 (en) * 1997-11-14 2012-04-25 Pacira Pharmaceuticals, Inc. Production of multivesicular liposomes
ES2238775T3 (en) * 1997-11-19 2005-09-01 Hercules Incorporated FLUIDIFIED POLYMERIC SUSPENSIONS OF CATIONIC POLYSACARIDS IN EMOLIENTS AND THEIR USE IN THE PREPARATION OF COMPOSITIONS FOR PERSONAL CARE.
EP1061932B1 (en) 1997-11-20 2006-01-25 Gil Ja Jhon Pharmaceutical composition containing extracts of cervus nippon antlers having growth-stimulating activities of hematopoietic stem cells and megakaryocytes
SI0937456T1 (en) * 1998-02-23 2004-12-31 Cilag Ag International Erythropoietin liposomal dispersion
DE69910183T2 (en) 1998-03-11 2004-06-03 Grelan Pharmaceutical Co., Ltd., Hamura COLONELY SPIRLING COMPOSITIONS
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
KR20020059415A (en) * 1999-09-27 2002-07-12 스티븐 씨. 큐웨이 Compositions of tocol-soluble therapeutics
US6835750B1 (en) * 2000-05-01 2004-12-28 Accera, Inc. Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II
AU2001264079A1 (en) 2000-06-14 2001-12-24 William Leslie Porter Lipids for modulating immune response
US6967028B2 (en) 2000-07-31 2005-11-22 Mainelab Prolonged release microspheres for injectable administration
IL142535A0 (en) 2001-04-11 2002-03-10 Yeda Res & Dev Pharmaceutical compositions for the treatment of inflammation
IL158322A0 (en) * 2001-04-18 2004-05-12 Prometic Biosciences Inc Medium-chain length fatty acids, glycerides and analogues as neutrophil survival and activation factors
US20040052836A1 (en) * 2002-09-13 2004-03-18 Li Luk Chiu Pharmaceutical compositions containing at least one stable liposphere having an improved shelf life
US6725510B1 (en) * 2003-04-25 2004-04-27 Almetta Clyburn Inclining coffin
JP5214880B2 (en) 2003-07-25 2013-06-19 プロメティック、バイオサイエンシーズ、インコーポレーテッド Production of metal salts of medium chain fatty acids
KR20070063507A (en) * 2004-09-03 2007-06-19 프로메틱 바이오사이언시즈 인코포레이티드 Substituted purinyl derivatives with immunomodulator and chemoprotective activity and use alone or with medium-chain length fatty acids or glycerides
US8071580B2 (en) 2004-10-01 2011-12-06 Prometic Biosciences Inc. Medium-chain length fatty alcohols as stimulators of hematopoiesis

Also Published As

Publication number Publication date
MA27664A1 (en) 2005-12-01
JP5390070B2 (en) 2014-01-15
EA009939B1 (en) 2008-04-28
IL170057A (en) 2011-09-27
DK1592416T3 (en) 2009-04-20
CN1753665A (en) 2006-03-29
AP2005003367A0 (en) 2005-09-30
AU2004210193A1 (en) 2004-08-19
DE04708802T1 (en) 2006-06-22
WO2004069237A1 (en) 2004-08-19
CA2515160C (en) 2013-01-08
NZ541593A (en) 2009-05-31
AU2004210193B2 (en) 2007-07-12
EA200501267A1 (en) 2006-02-24
SI1592416T1 (en) 2009-06-30
US20060128800A1 (en) 2006-06-15
TNSN05189A1 (en) 2007-06-11
CA2515160A1 (en) 2004-08-19
MY140913A (en) 2010-01-29
PT1592416E (en) 2009-04-03
CY1108963T1 (en) 2014-07-02
KR101120775B1 (en) 2012-04-18
EP1592416A1 (en) 2005-11-09
JP2006516987A (en) 2006-07-13
US9682054B2 (en) 2017-06-20
CN100427081C (en) 2008-10-22
EP1592416B1 (en) 2009-01-07
ES2255467T1 (en) 2006-07-01
NO334085B1 (en) 2013-12-09
DE602004018902D1 (en) 2009-02-26
JO2705B1 (en) 2014-03-15
NO20053994D0 (en) 2005-08-26
ES2255467T3 (en) 2009-05-01
ZA200506246B (en) 2006-12-27
AR043120A1 (en) 2005-07-20
NO20053994L (en) 2005-10-06
MXPA05008382A (en) 2005-11-04
KR20050118671A (en) 2005-12-19
ATE419846T1 (en) 2009-01-15

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. A61K 31/20; A61P 7/00

Ipc: A61K 31/20 (2011.01), A61P 7/00 (2011.01)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B25A Requested transfer of rights approved

Owner name: PROMETIC PHARMA SMT LIMITED (CA)