BRPI0407415A - Método de fabricar um preparado lipossÈmico - Google Patents

Método de fabricar um preparado lipossÈmico

Info

Publication number
BRPI0407415A
BRPI0407415A BR0407415-7A BRPI0407415A BRPI0407415A BR PI0407415 A BRPI0407415 A BR PI0407415A BR PI0407415 A BRPI0407415 A BR PI0407415A BR PI0407415 A BRPI0407415 A BR PI0407415A
Authority
BR
Brazil
Prior art keywords
preparation
organic solvent
miscible organic
making
water
Prior art date
Application number
BR0407415-7A
Other languages
English (en)
Inventor
Shastri Bhamidipati
Zafeer Ahmad
Imran Ahmad
Original Assignee
Neopharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neopharm Inc filed Critical Neopharm Inc
Publication of BRPI0407415A publication Critical patent/BRPI0407415A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

"MéTODO DE FABRICAR UM PREPARADO LIPOSSÈMICO". A presente invenção proporciona processos de fabricação para preparados lipossómicos. De acordo com os métodos, uma fração lipídica é dissolvida em um solvente orgânico miscível em água. Tal solução, que compreende a fração lipídica, pode ser adicionada e misturada com uma solução aquosa sob condições que formem um preparado lipossómico bruto. Desejavelmente, o preparado pode incluir um ou mais princípios ativos. O preparado lipossómico bruto pode ser mais processado, conforme desejado, por exemplo, por meio de fracionamento ou redução de tamanho, remoção do solvente orgânico miscível em água, secagem por congelamento ou outro tratamento. Os métodos possibilitam a produção de formulações lipossómicas em escala maior ou em escala comercial.
BR0407415-7A 2003-02-11 2004-02-11 Método de fabricar um preparado lipossÈmico BRPI0407415A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44689503P 2003-02-11 2003-02-11
PCT/US2004/004555 WO2004071466A2 (en) 2003-02-11 2004-02-11 Manufacturing process for liposomal preparations

Publications (1)

Publication Number Publication Date
BRPI0407415A true BRPI0407415A (pt) 2006-01-10

Family

ID=32869567

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0407415-7A BRPI0407415A (pt) 2003-02-11 2004-02-11 Método de fabricar um preparado lipossÈmico

Country Status (9)

Country Link
US (1) US20060034908A1 (pt)
EP (1) EP1613284A2 (pt)
JP (1) JP2006517594A (pt)
KR (1) KR20050105455A (pt)
CN (1) CN1753657A (pt)
BR (1) BRPI0407415A (pt)
EA (1) EA200501285A1 (pt)
MX (1) MXPA05008489A (pt)
WO (1) WO2004071466A2 (pt)

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WO2006050327A2 (en) * 2004-10-28 2006-05-11 Alza Corporation Lyophilized liposome formulations and method
MX2007005234A (es) * 2004-10-29 2008-03-10 Neopharm Inc Proceso de fabricacion para preparaciones liposomales.
US20080121733A1 (en) * 2006-11-29 2008-05-29 Donald Ackley Droplet generating device and method
US7824708B2 (en) * 2006-12-11 2010-11-02 Access Business Group International Llc Liposome containing cardiolipin for improvement of mitochondrial function
EP2146692A1 (en) * 2007-03-19 2010-01-27 Fresenius Kabi Oncology Limited Proliposomal and liposomal compositions
KR20080101056A (ko) * 2007-05-15 2008-11-21 한국화학연구원 지질나노입자를 포함하는 디테르페노이드 알칼로이드계약물 용액 및 이의 제조방법
CN106310293A (zh) 2007-09-27 2017-01-11 免疫疫苗技术有限公司 在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用
US20100209452A1 (en) * 2007-10-03 2010-08-19 Immunovaccine Technologies, Inc Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof
WO2009146523A1 (en) 2008-06-05 2009-12-10 Immunovaccine Technologies Inc. Compositions comprising liposomes, an antigen, a polynucleotide and a carrier comprising a continuous phase of a hydrophobic substance
US9445975B2 (en) * 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
US20110250262A1 (en) * 2008-12-24 2011-10-13 Biomedcore, Inc. Method for producing liposome and method for dissolving cholesterol
WO2010118200A2 (en) * 2009-04-08 2010-10-14 Brian Salvatore Liposomal formulations of tocopheryl amides
JP5771366B2 (ja) 2009-09-02 2015-08-26 株式会社バイオメッドコア リポソーム製造装置及び方法
CA2781527C (en) 2009-09-23 2017-10-24 Indu Javeri Methods for the preparation of liposomes
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
US20110250264A1 (en) 2010-04-09 2011-10-13 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
EP2729127B1 (en) * 2011-07-04 2018-05-02 Statens Serum Institut Methods for producing liposomes
CN103181898B (zh) * 2012-11-23 2016-03-09 杭州师范大学 一种奥沙利铂脂质体及其应用
JP2015193580A (ja) * 2014-03-31 2015-11-05 テルモ株式会社 アムホテリシンｂリポソームの製造方法
LT3466432T (lt) 2014-05-15 2020-12-28 Insmed Incorporated Būdai, skirti plaučių netuberkuliozinėms mikobakterinėms infekcijoms gydyti
WO2016191547A1 (en) 2015-05-26 2016-12-01 Comfort Care For Animals Llc Liposome loading
JP6495466B2 (ja) * 2015-10-07 2019-04-03 塩水港精糖株式会社 タキサン化合物を内包するリポソーム
US20180361342A1 (en) * 2015-12-08 2018-12-20 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Method for Preparing Liposome
WO2017097197A1 (zh) * 2015-12-08 2017-06-15 正大天晴药业集团股份有限公司 美西替康的药物组合物
CN111132753B (zh) 2017-09-04 2022-05-27 一丸自然美健有限公司 pH敏感性脂质体及其制造方法
EP3773505B1 (en) * 2018-03-30 2026-04-29 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
JP7449275B2 (ja) 2018-05-02 2024-03-13 インスメッド インコーポレイテッド リポソーム薬物製剤の製造方法
CN109925956A (zh) * 2019-04-29 2019-06-25 苏州艾特森制药设备有限公司 一种实验室脂质体制备系统

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Also Published As

Publication number Publication date
EA200501285A1 (ru) 2006-02-24
WO2004071466A2 (en) 2004-08-26
MXPA05008489A (es) 2005-10-18
WO2004071466A3 (en) 2004-12-02
EP1613284A2 (en) 2006-01-11
JP2006517594A (ja) 2006-07-27
KR20050105455A (ko) 2005-11-04
CN1753657A (zh) 2006-03-29
US20060034908A1 (en) 2006-02-16

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]