BRPI0408389A - derivados de cromeno como agentes antiinflamatórios - Google Patents

derivados de cromeno como agentes antiinflamatórios

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Publication number
BRPI0408389A
BRPI0408389A BRPI0408389-0A BRPI0408389A BRPI0408389A BR PI0408389 A BRPI0408389 A BR PI0408389A BR PI0408389 A BRPI0408389 A BR PI0408389A BR PI0408389 A BRPI0408389 A BR PI0408389A
Authority
BR
Brazil
Prior art keywords
inflammatory agents
chromene derivatives
compounds
derivatives
chromene
Prior art date
Application number
BRPI0408389-0A
Other languages
English (en)
Inventor
Karl W Aston
David L Brown
Jeffrey S Carter
Angela M Deprow
Theresa R Fletcher
E Ann Hallinan
Bruce C Hamper
Renee M Huff
James R Kiefer Jr
Francis Koszyk
Steven W Kramer
Subo Liao
David Limburg
John R Springer
Sofya Tsymbalow
Lijuan Jane Wang
Li Xing
Yi Yu
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BRPI0408389A publication Critical patent/BRPI0408389A/pt

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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)

Abstract

"DERIVADOS DE CROMENO COMO AGENTES ANTIINFLAMATóRIOS". O conteúdo da invenção diz respeito a métodos e compostos que têm utilização no tratamento de um estado associado a distúrbios mediados pela ciclooxigenase-2. Os compostos de particular interesse são benzopiranos e os seus análogos definidos pela fórmula (I), em que Z, X, R1, R2, R3 e R4 são como descrito na especificação.
BRPI0408389-0A 2003-03-31 2004-03-19 derivados de cromeno como agentes antiinflamatórios BRPI0408389A (pt)

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PCT/IB2004/000939 WO2004087687A1 (en) 2003-03-31 2004-03-19 Chromene derivatives as anti-inflammatory agents

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Publication number Priority date Publication date Assignee Title
US6034256A (en) * 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
CA2573547A1 (en) * 2004-07-23 2006-02-02 Warner-Lambert Company Llc Photoracemization of 2-trifluoromethyl-2h-chromene-3-carboxylic acid derivatives
WO2006011052A1 (en) * 2004-07-23 2006-02-02 Pharmacia & Upjohn Company Llc Method for the racemization of 2-trifluoro-2h-chromene-3-carboxylic acids
BRPI0512251A (pt) * 2004-07-23 2008-02-19 Pharmacia & Upjohn Co Llc método enantioseletivo para separação de derivados do ácido 2-trifluormetil-2h-cromeno-3-carboxìlico substituìdo
WO2006040676A1 (en) * 2004-10-12 2006-04-20 Pharmacia & Upjohn Company Llc Nitrosated benzopyran compounds as novel cyclooxygenase-2 selective inhibitors
GB0608825D0 (en) * 2006-05-04 2006-06-14 Glaxo Group Ltd Compounds
CN102757417B (zh) 2012-06-18 2014-09-24 中国科学院广州生物医药与健康研究院 氘代苯并吡喃类化合物及其应用
JP6061373B2 (ja) * 2012-07-24 2017-01-18 国立研究開発法人産業技術総合研究所 ２−ヒドロキシベンズアルデヒド化合物、これを含有するコラーゲン細胞外分泌阻害剤及び医薬品組成物
CN103012350B (zh) * 2012-12-07 2015-02-04 中国科学院广州生物医药与健康研究院 苯并吡喃类手性化合物的合成方法
BR112016016386B1 (pt) 2014-01-14 2023-02-23 Euclises Pharmaceuticals, Inc Composto ou um sal ou solvato do mesmo, composição farmacêutica e uso de um composto na preparação de um medicamento
WO2015153813A1 (en) 2014-04-01 2015-10-08 Howard Hughes Medical Institute Azetidine-substituted fluorescent compounds
WO2016203017A1 (en) * 2015-06-19 2016-12-22 Sabic Global Technologies B.V. Procatalyst for polymerization of olefins comprising an aminobenzoate internal donor and a 1,3-diether internal donor in a specific ratio
GB2543550A (en) 2015-10-21 2017-04-26 Hox Therapeutics Ltd Peptides
CN113286792B (zh) * 2018-12-14 2023-12-05 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的含n色烯-4-酮衍生物
US12440581B2 (en) 2019-09-19 2025-10-14 Howard Hughes Medical Institute Fluorophores for super-resolution imaging
CN118994078B (zh) * 2024-07-29 2026-03-20 大连理工大学 一种2-三氟甲基-3-芳基-2h-色烯醚类衍生物、制备方法及应用

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US6034256A (en) * 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation

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PA8599301A1 (es) 2004-12-16
CL2004000664A1 (es) 2005-02-04
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PE20050393A1 (es) 2005-05-30
UY28247A1 (es) 2004-11-08
US20050148627A1 (en) 2005-07-07
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TW200504045A (en) 2005-02-01
CA2519291A1 (en) 2004-10-14
MXPA05010423A (es) 2006-04-24
AR043951A1 (es) 2005-08-17
WO2004087687A1 (en) 2004-10-14
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