BRPI0408417A - métodos para a produção de um resìduo de gla purificado contendo serina protease, para a purificação de um resìduo de gla contendo serina protease e para estabilização de um resìduo de gla contendo serina protease, e, composição - Google Patents

métodos para a produção de um resìduo de gla purificado contendo serina protease, para a purificação de um resìduo de gla contendo serina protease e para estabilização de um resìduo de gla contendo serina protease, e, composição

Info

Publication number
BRPI0408417A
BRPI0408417A BRPI0408417-9A BRPI0408417A BRPI0408417A BR PI0408417 A BRPI0408417 A BR PI0408417A BR PI0408417 A BRPI0408417 A BR PI0408417A BR PI0408417 A BRPI0408417 A BR PI0408417A
Authority
BR
Brazil
Prior art keywords
serine protease
gla residue
containing gla
purifying
residue
Prior art date
Application number
BRPI0408417-9A
Other languages
English (en)
Inventor
Janus Krarup
Egon Persson
Original Assignee
Novo Nordisk Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Healthcare Ag filed Critical Novo Nordisk Healthcare Ag
Publication of BRPI0408417A publication Critical patent/BRPI0408417A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"MéTODOS PARA A PRODUçãO DE UM RESìDUO DE GLA PURIFICADO CONTENDO SERINA PROTEASE, PARA A PURIFICAçãO DE UM RESìDUO DE GLA CONTENDO SERINA PROTEASE E PARA ESTABILIZAçãO DE UM RESìDUO DE GLA CONTENDO SERINA PROTEASE, E, COMPOSIçãO". A presente invenção diz respeito a um processo para a purificação de uma protease.
BRPI0408417-9A 2003-03-18 2004-03-18 métodos para a produção de um resìduo de gla purificado contendo serina protease, para a purificação de um resìduo de gla contendo serina protease e para estabilização de um resìduo de gla contendo serina protease, e, composição BRPI0408417A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200300413 2003-03-18
US45780903P 2003-03-26 2003-03-26
PCT/DK2004/000183 WO2004083421A1 (en) 2003-03-18 2004-03-18 Method for the production of gla-residue containing serine proteases

Publications (1)

Publication Number Publication Date
BRPI0408417A true BRPI0408417A (pt) 2006-03-21

Family

ID=33031170

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408417-9A BRPI0408417A (pt) 2003-03-18 2004-03-18 métodos para a produção de um resìduo de gla purificado contendo serina protease, para a purificação de um resìduo de gla contendo serina protease e para estabilização de um resìduo de gla contendo serina protease, e, composição

Country Status (10)

Country Link
EP (2) EP3103869A1 (pt)
JP (1) JP4885707B2 (pt)
KR (1) KR101204712B1 (pt)
CN (4) CN1780637A (pt)
AU (1) AU2004221758B2 (pt)
BR (1) BRPI0408417A (pt)
CA (1) CA2519020A1 (pt)
MX (1) MXPA05009770A (pt)
RU (1) RU2364626C2 (pt)
WO (1) WO2004083421A1 (pt)

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US7985569B2 (en) * 2003-11-19 2011-07-26 Danisco Us Inc. Cellulomonas 69B4 serine protease variants
JP2008539208A (ja) * 2005-04-28 2008-11-13 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 活性化型のｖｉｉ因子ポリペプチドを含んでいる閉鎖容器、調製する方法、並びにキットおよび前記キットを使用する方法
AU2012213951B2 (en) * 2005-04-28 2014-10-16 Novo Nordisk Health Care Ag A closed container comprising an activated factor VII polypeptide, processes for the preparation of the same, and a kit and a method for use of the kit
KR20080039969A (ko) * 2005-08-31 2008-05-07 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Ｇｌａ 도메인을 결합하는 인간 ｆｖｉｉ 단일클론의 항체및 이것의 사용
TWI465247B (zh) 2008-04-11 2014-12-21 Catalyst Biosciences Inc 經修飾的因子ｖｉｉ多肽和其用途
JP5788803B2 (ja) * 2008-12-02 2015-10-07 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー ポリペプチド精製
US9896677B2 (en) 2010-01-18 2018-02-20 Novo Nordisk Health Care Ag Purification of blood coagulation factors
MX375112B (es) * 2010-07-09 2025-03-06 Biogen Hemophilia Inc Polipéptidos de factor ix y métodos para usarlos.
WO2012173260A1 (ja) * 2011-06-17 2012-12-20 学校法人東日本学園・北海道医療大学 ループスアンチコアグラント検出用血液凝固時間の測定方法
CN103539852B (zh) * 2012-07-12 2015-08-12 上海泰龙生物医药科技有限公司 一种从细胞培养液中分离纯化重组人凝血八因子的方法
US8883979B2 (en) 2012-08-31 2014-11-11 Bayer Healthcare Llc Anti-prolactin receptor antibody formulations
CN109876136B (zh) * 2019-02-21 2019-12-31 国药集团成都信立邦生物制药有限公司 一种醋酸奥曲肽冻干粉针剂及其制备方法
EP3833381B1 (en) 2019-08-15 2022-08-03 Catalyst Biosciences, Inc. Modified factor vii polypeptides for subcutaneous administration

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ZA862768B (en) * 1985-04-17 1986-12-30 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
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JP5184738B2 (ja) * 2002-05-03 2013-04-17 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 修飾第ｖｉｉ因子の安定化された固体組成物

Also Published As

Publication number Publication date
RU2005132170A (ru) 2007-06-20
JP4885707B2 (ja) 2012-02-29
CN101818138A (zh) 2010-09-01
RU2364626C2 (ru) 2009-08-20
AU2004221758A1 (en) 2004-09-30
AU2004221758B2 (en) 2010-07-22
KR20050110016A (ko) 2005-11-22
CN1761747A (zh) 2006-04-19
MXPA05009770A (es) 2005-11-17
EP1611236A1 (en) 2006-01-04
CN101818137A (zh) 2010-09-01
CN1780637A (zh) 2006-05-31
KR101204712B1 (ko) 2012-11-27
CA2519020A1 (en) 2004-09-30
EP3103869A1 (en) 2016-12-14
JP2006520200A (ja) 2006-09-07
WO2004083421A1 (en) 2004-09-30

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25G Requested change of headquarter approved

Owner name: NOVO NORDISK HEALTH CARE AG (CH)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application fees: application dismissed [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]