BRPI0408516A - composições autoemulsificantes, métodos de uso e preparação - Google Patents
composições autoemulsificantes, métodos de uso e preparaçãoInfo
- Publication number
- BRPI0408516A BRPI0408516A BRPI0408516-7A BRPI0408516A BRPI0408516A BR PI0408516 A BRPI0408516 A BR PI0408516A BR PI0408516 A BRPI0408516 A BR PI0408516A BR PI0408516 A BRPI0408516 A BR PI0408516A
- Authority
- BR
- Brazil
- Prior art keywords
- self
- emulsifying compositions
- preparation
- compositions
- prepared
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 239000003995 emulsifying agent Substances 0.000 abstract 2
- 231100000045 chemical toxicity Toxicity 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 238000000265 homogenisation Methods 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Eyeglasses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Colloid Chemistry (AREA)
Abstract
"COMPOSIçõES AUTOEMULSIFICANTES, MéTODOS DE USO E PREPARAçãO". Preparação de composições autoemulsificantes que são preparadas sem homogeneização mecânica é descrita. Essas composições autoemulsificantes são preparadas usando um ou dois tensoativos. Isso prove a vantagem de uma razão de peso baixa de componente emulsificante para componente oleoso e menos preocupações com toxidez química, resultando em vantagens de conforto e segurança sobre as emulsões empregando mais de dois emulsificantes. Conseqüentemente, as composições autoemulsificantes descritas são idealmente adequadas para aplicações oftálmicas incluindo administração de agentes terapêuticos ao olho. Composições autoemulsificantes preparadas através do método descrito são descritas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/392,375 US20040185068A1 (en) | 2003-03-18 | 2003-03-18 | Self-emulsifying compositions, methods of use and preparation |
| PCT/US2004/008076 WO2004082625A2 (en) | 2003-03-18 | 2004-03-17 | Self-emulsifying compositions, methods of use and preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0408516A true BRPI0408516A (pt) | 2006-03-07 |
Family
ID=32987875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0408516-7A BRPI0408516A (pt) | 2003-03-18 | 2004-03-17 | composições autoemulsificantes, métodos de uso e preparação |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20040185068A1 (pt) |
| EP (1) | EP1603607A2 (pt) |
| JP (1) | JP2006526579A (pt) |
| CN (1) | CN1791383A (pt) |
| AU (1) | AU2004222295B2 (pt) |
| BR (1) | BRPI0408516A (pt) |
| CA (1) | CA2519300A1 (pt) |
| WO (1) | WO2004082625A2 (pt) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8858961B2 (en) | 2000-07-14 | 2014-10-14 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| US20050026924A1 (en) * | 2000-07-14 | 2005-02-03 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| AU2011250793B2 (en) * | 2000-07-14 | 2012-11-29 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| US20040185068A1 (en) * | 2003-03-18 | 2004-09-23 | Zhi-Jian Yu | Self-emulsifying compositions, methods of use and preparation |
| US20050196370A1 (en) * | 2003-03-18 | 2005-09-08 | Zhi-Jian Yu | Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye |
| US20060251685A1 (en) * | 2003-03-18 | 2006-11-09 | Zhi-Jian Yu | Stable ophthalmic oil-in-water emulsions with Omega-3 fatty acids for alleviating dry eye |
| JP5382973B2 (ja) * | 2003-12-26 | 2014-01-08 | ロート製薬株式会社 | 粘度低下が防止された組成物 |
| JP5318850B2 (ja) * | 2003-12-26 | 2013-10-16 | ロート製薬株式会社 | 粘度低下が防止された組成物 |
| JP5382972B2 (ja) * | 2003-12-26 | 2014-01-08 | ロート製薬株式会社 | 粘度低下が防止された組成物 |
| DE602005020912D1 (de) * | 2004-03-18 | 2010-06-10 | Galderma Sa | Ivermectin enthaltende creme |
| US7544671B2 (en) * | 2004-05-07 | 2009-06-09 | S.K. Pharmaceuticals, Inc. | Stabilized hyaluronan preparations and related methods |
| US8288362B2 (en) * | 2004-05-07 | 2012-10-16 | S.K. Pharmaceuticals, Inc. | Stabilized glycosaminoglycan preparations and related methods |
| BRPI0512864B8 (pt) * | 2004-07-01 | 2021-05-25 | Johnson & Johnson Vision Care | composição oftálmica, uso de pelo menos um ácido graxo ômega-6 e pelo menos um ácido graxo ômega-3 e método para preparar a referida composição |
| US20070265341A1 (en) * | 2004-07-01 | 2007-11-15 | The Schepens Eye Research Institute Inc. | Compositions and methods for treating eye disorders and conditions |
| JP4999304B2 (ja) * | 2004-09-27 | 2012-08-15 | ロート製薬株式会社 | ヒアルロン酸又はその塩を含有する粘膜適用組成物 |
| US9161905B2 (en) * | 2005-01-12 | 2015-10-20 | Ocular Research Of Boston, Inc. | Dry eye treatment |
| US7297679B2 (en) * | 2005-07-13 | 2007-11-20 | Allergan, Inc. | Cyclosporin compositions |
| US7288520B2 (en) * | 2005-07-13 | 2007-10-30 | Allergan, Inc. | Cyclosporin compositions |
| US20070015691A1 (en) * | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Cyclosporin compositions |
| US8288348B2 (en) | 2005-07-13 | 2012-10-16 | Allergan, Inc. | Cyclosporin compositions |
| US7202209B2 (en) * | 2005-07-13 | 2007-04-10 | Allergan, Inc. | Cyclosporin compositions |
| US7501393B2 (en) * | 2005-07-27 | 2009-03-10 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
| US7745400B2 (en) * | 2005-10-14 | 2010-06-29 | Gregg Feinerman | Prevention and treatment of ocular side effects with a cyclosporin |
| US9839667B2 (en) | 2005-10-14 | 2017-12-12 | Allergan, Inc. | Prevention and treatment of ocular side effects with a cyclosporin |
| US20070087962A1 (en) * | 2005-10-17 | 2007-04-19 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
| US20070138439A1 (en) * | 2005-12-21 | 2007-06-21 | 3M Innovative Properties Company | Denaturant for ethanol |
| US20070148127A1 (en) * | 2005-12-22 | 2007-06-28 | Heiler David J | Antimicrobial ophthalmic treatment system and method |
| US7767217B2 (en) * | 2006-03-14 | 2010-08-03 | Foresight Biotherapeutics | Ophthalmic compositions comprising povidone-iodine |
| US20070264226A1 (en) * | 2006-05-10 | 2007-11-15 | Karagoezian Hampar L | Synergistically enhanced disinfecting solutions |
| WO2008120249A1 (en) | 2007-03-30 | 2008-10-09 | Sifi S.P.A. | Pharmaceutical formulations based on apolar and polar lipids for ophthalmic use |
| EP1985298A1 (en) * | 2007-04-24 | 2008-10-29 | Azad Pharma AG | Ophtalmic oil-in-water emulsions containing prostaglandins |
| US20110144010A1 (en) * | 2007-06-01 | 2011-06-16 | Novo Nordisk A/S | Spontaneously Dispersible Preconcentrates Including a Peptide Drug in a Solid or Semisolid Carrier |
| US20090036404A1 (en) * | 2007-08-02 | 2009-02-05 | Macleod Steven K | Ophthalmic compositions comprising a carboxyl-modified fructan or a salt thereof |
| WO2009084021A2 (en) * | 2007-10-16 | 2009-07-09 | Sun Pharma Advanced Research Company Limited | Novel ophthalmic compositions |
| WO2009067734A1 (en) * | 2007-11-28 | 2009-06-04 | Commonwealth Scientific And Industrial Research Organisation | Nanoemulsions |
| US20130059796A1 (en) * | 2007-12-13 | 2013-03-07 | Allergan, Inc | Cyclosporin compositions |
| US9314524B2 (en) * | 2007-12-31 | 2016-04-19 | Calla Therapeutics Llc | Topical formulations of Flucytosine |
| CN102037008B (zh) | 2008-03-18 | 2016-08-31 | 诺沃-诺迪斯克有限公司 | 蛋白酶稳定化的、酰化胰岛素类似物 |
| WO2010091362A2 (en) * | 2009-02-06 | 2010-08-12 | Mesh Therapeutics, Llc | Topical formulations comprising ion channel modulators |
| US20100273730A1 (en) * | 2009-04-27 | 2010-10-28 | Innopharmax, Inc. | Self-emulsifying pharmaceutical compositions of hydrophilic drugs and preparation thereof |
| US8496976B2 (en) | 2009-06-05 | 2013-07-30 | Allergan, Inc. | Artificial tears and therapeutic uses |
| WO2011001951A1 (ja) * | 2009-06-30 | 2011-01-06 | ライオン株式会社 | 眼科用組成物 |
| EP2488022B1 (en) | 2009-10-16 | 2018-01-10 | Mochida Pharmaceutical Co., Ltd. | Compositions |
| CL2012001399A1 (es) | 2009-12-03 | 2013-03-08 | Novartis Ag | Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion. |
| JP5751678B2 (ja) * | 2009-12-03 | 2015-07-22 | ノバルティス アーゲー | マイクロフルイダイゼーションのための相互作用チャンバおよび背圧チャンバの構成 |
| DE102009056884B4 (de) | 2009-12-03 | 2021-03-18 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
| DE102009056883B4 (de) | 2009-12-03 | 2012-08-16 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
| EP2506832B1 (en) | 2009-12-03 | 2014-02-26 | Novartis AG | Hydrophilic filtration during manufacture of vaccine adjuvants |
| RS52748B (sr) | 2009-12-03 | 2013-08-30 | Novartis Ag | Cirkulacija komponenti tokom homogenizacije emulzija |
| IT1404931B1 (it) * | 2010-06-11 | 2013-12-09 | Medivis S R L | Composizioni oftalmiche per la somministrazione di principi attivi liposolubili . |
| WO2012041910A1 (de) | 2010-10-01 | 2012-04-05 | Elektra Management S.R.O. | Lösung von guanidinium-verbindungen, verfahren unter einsatz dieser lösung sowie deren verwendung |
| CA2858574C (en) * | 2011-12-07 | 2017-05-30 | Allergan, Inc. | Efficient lipid delivery to human tear film using a salt-sensitive emulsion system |
| US9481721B2 (en) | 2012-04-11 | 2016-11-01 | Novo Nordisk A/S | Insulin formulations |
| US9132106B2 (en) * | 2013-03-14 | 2015-09-15 | Abbott Medical Optics Inc. | Synergistic ophthalmic compositions for disinfecting contact lenses |
| US9089562B2 (en) * | 2013-08-28 | 2015-07-28 | Presbyopia Therapies Llc | Compositions and methods for the treatment of presbyopia |
| KR20170120161A (ko) * | 2015-03-05 | 2017-10-30 | 알러간, 인코포레이티드 | 안과용 약물 전달을 위한 자가-유화 약물 전달 시스템(sedds) |
| US20200397727A1 (en) * | 2016-10-12 | 2020-12-24 | Ps Therapies Ltd | Drug vehicle compositions and methods of use thereof |
| US20230285286A1 (en) * | 2016-10-12 | 2023-09-14 | Ps Therapy, Inc. | Drug vehicle compositions and methods of use thereof |
| US11583496B2 (en) * | 2016-10-12 | 2023-02-21 | PS Therapy Inc. | Drug vehicle compositions and methods of use thereof |
| CN110114119B (zh) * | 2016-10-12 | 2022-05-31 | Ps治疗有限公司 | 人工泪液、隐形眼镜和药物载体组合物及其使用方法 |
| US20190262290A1 (en) * | 2016-10-12 | 2019-08-29 | Ps Therapies Ltd | Drug vehicle compositions and methods of use thereof |
| TWI700091B (zh) | 2016-12-16 | 2020-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 含胰島素醫藥組成物 |
| AU2019261437B2 (en) | 2018-04-27 | 2024-11-07 | Allergan, Inc. | Sodium chlorite compositions with enhanced anti-microbial efficacy and reduced toxicity |
| WO2020071297A1 (ja) * | 2018-10-01 | 2020-04-09 | 千寿製薬株式会社 | 水性液剤 |
| WO2021262184A1 (en) * | 2020-06-26 | 2021-12-30 | Renden Tashiro | Disinfectant solution and article coated with disinfectant solution |
| CN112842936A (zh) * | 2021-03-15 | 2021-05-28 | 傅博 | 一种眼部清洁液及其制备方法 |
| WO2025108987A1 (en) * | 2023-11-21 | 2025-05-30 | Bausch + Lomb Ireland Limited | Compositions and methods for treating eyetear film deficiency and redeye |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4818614A (en) * | 1985-07-29 | 1989-04-04 | Shiseido Company Ltd. | Modified powder |
| KR920003601B1 (ko) * | 1987-09-03 | 1992-05-04 | 유니버시티 어브 죠지아 리서취 화운데이션 인코포레이티드 | 점안 싸이클로스포린(cyclosporin)의 조성물 |
| US5407683A (en) * | 1990-06-01 | 1995-04-18 | Research Corporation Technologies, Inc. | Pharmaceutical solutions and emulsions containing taxol |
| IL101007A (en) * | 1992-02-18 | 1997-08-14 | Pharmos Ltd | Dry stable compositions prepared by lyophilization |
| DE4206154A1 (de) * | 1992-02-28 | 1993-09-02 | Wella Ag | Verfahren zur gewinnung von apfelwachs, durch diese verfahren erhaeltliches apfelwachs sowie apfelwachshaltige kosmetische mittel |
| IL101241A (en) * | 1992-03-16 | 1997-11-20 | Yissum Res Dev Co | Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier |
| IL103907A0 (en) * | 1992-11-27 | 1993-04-04 | Pharmos Corp | Ophthalmic compositions |
| EP0656779B1 (en) * | 1992-08-28 | 2000-04-12 | Pharmos Corporation | Submicron emulsions as ocular drug delivery vehicles |
| EP0596304B1 (de) * | 1992-10-31 | 1998-04-01 | Th. Goldschmidt AG | Kosmetische oder pharmazeutische Zubereitungen |
| GB9514878D0 (en) * | 1995-07-20 | 1995-09-20 | Danbiosyst Uk | Vitamin E as a solubilizer for drugs contained in lipid vehicles |
| US5679327A (en) * | 1995-08-25 | 1997-10-21 | Johnson Products Co., Inc. | Hair straightening emulsion |
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| GB2326337A (en) * | 1997-06-20 | 1998-12-23 | Phares Pharma Holland | Homogeneous lipid compositions for drug delivery |
| NZ502567A (en) * | 1997-07-29 | 2002-03-28 | Upjohn Co | Self-emulsifying formulation for lipophilic compounds containing a pyranone and a mixture of monoglycerides and diglycerides |
| ATE265847T1 (de) * | 1997-07-29 | 2004-05-15 | Upjohn Co | Selbstemulgierbare formulierung enthaltend lipophile verbindungen |
| FR2767069B1 (fr) * | 1997-08-08 | 1999-09-17 | Ard Sa | Composition emulsionnante a base de polyglycosides et d'alcool gras |
| US6979456B1 (en) * | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| AU3843999A (en) * | 1998-05-07 | 1999-11-23 | Elan Corporation, Plc | Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems |
| FR2787027B1 (fr) * | 1998-12-14 | 2001-01-12 | Oreal | Nanoemulsion a base d'esters gras de sucre ou d'ethers gras de sucre et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique |
| US6309663B1 (en) * | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
| US6506394B1 (en) * | 1999-06-30 | 2003-01-14 | Kimberly-Clark Worldwide, Inc. | Delivery of a botanical extract to a treated substrate for transfer to skin |
| AU7638300A (en) * | 1999-10-20 | 2001-04-30 | Vesifact Ag | Microemulsion preconcentrates and microemulsions |
| GB0008785D0 (en) * | 2000-04-10 | 2000-05-31 | Novartis Ag | Organic compounds |
| WO2001097784A1 (en) * | 2000-06-23 | 2001-12-27 | Takeda Chemical Industries, Ltd. | Process for producing phospholipid-containing drugs |
| FR2819427B1 (fr) * | 2001-01-18 | 2003-04-11 | Oreal | Nanoemulsion translucide, son procede de fabrication et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique |
| US7235230B2 (en) * | 2001-10-24 | 2007-06-26 | Clariant Finance (Bvi) Limited | Leave-on compositions for personal care |
| US6656460B2 (en) * | 2001-11-01 | 2003-12-02 | Yissum Research Development | Method and composition for dry eye treatment |
| AU2002343555A1 (en) * | 2001-11-14 | 2003-05-26 | Texas Tech University | Eutectic-based self-nanoemulsified drug delivery system |
| US20030165545A1 (en) * | 2002-01-30 | 2003-09-04 | Allergan, Inc. | Ophthalmic compositions including oil-in-water emulsions, and methods for making and using same |
| US20040115287A1 (en) * | 2002-12-17 | 2004-06-17 | Lipocine, Inc. | Hydrophobic active agent compositions and methods |
| US20040137079A1 (en) * | 2003-01-08 | 2004-07-15 | Cook James N. | Contact lens and eye drop rewetter compositions and methods |
| US20050196370A1 (en) * | 2003-03-18 | 2005-09-08 | Zhi-Jian Yu | Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye |
| US20040185068A1 (en) * | 2003-03-18 | 2004-09-23 | Zhi-Jian Yu | Self-emulsifying compositions, methods of use and preparation |
-
2003
- 2003-03-18 US US10/392,375 patent/US20040185068A1/en not_active Abandoned
-
2004
- 2004-03-17 CA CA002519300A patent/CA2519300A1/en not_active Abandoned
- 2004-03-17 US US10/802,153 patent/US20040191284A1/en not_active Abandoned
- 2004-03-17 AU AU2004222295A patent/AU2004222295B2/en not_active Ceased
- 2004-03-17 CN CNA2004800134227A patent/CN1791383A/zh active Pending
- 2004-03-17 BR BRPI0408516-7A patent/BRPI0408516A/pt not_active IP Right Cessation
- 2004-03-17 JP JP2006507252A patent/JP2006526579A/ja active Pending
- 2004-03-17 WO PCT/US2004/008076 patent/WO2004082625A2/en not_active Ceased
- 2004-03-17 EP EP04757532A patent/EP1603607A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004082625A2 (en) | 2004-09-30 |
| WO2004082625A3 (en) | 2004-11-18 |
| AU2004222295A1 (en) | 2004-09-30 |
| EP1603607A2 (en) | 2005-12-14 |
| CA2519300A1 (en) | 2004-09-30 |
| AU2004222295B2 (en) | 2008-07-17 |
| CN1791383A (zh) | 2006-06-21 |
| US20040185068A1 (en) | 2004-09-23 |
| US20040191284A1 (en) | 2004-09-30 |
| JP2006526579A (ja) | 2006-11-24 |
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