BRPI0408893A - benzimidazóis cìclicos - Google Patents

benzimidazóis cìclicos

Info

Publication number
BRPI0408893A
BRPI0408893A BRPI0408893-0A BRPI0408893A BRPI0408893A BR PI0408893 A BRPI0408893 A BR PI0408893A BR PI0408893 A BRPI0408893 A BR PI0408893A BR PI0408893 A BRPI0408893 A BR PI0408893A
Authority
BR
Brazil
Prior art keywords
cyclic
benzimidazoles
gastric
cyclic benzimidazoles
substituents
Prior art date
Application number
BRPI0408893-0A
Other languages
English (en)
Inventor
Wilm Buhr
M Vittoria Chiesa
Peter Jan Zimmermann
Christof Brehm
Andreas Palmer
Stefan Postius
Wolfgang Kromer
Wolfgang-Alexander Simon
Joerg Senn-Bilfinger
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of BRPI0408893A publication Critical patent/BRPI0408893A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"BENZIMIDAZóIS CìCLICOS". A presente invenção refere-se a benzimidazóis cíclicos da fórmula (1) nos quais os substituintes e símbolos têm os significados indicados na descrição. Os compostos têm inibição de secreção gástrica e excelentes propriedades de ação protetora gástrica e intestinal.
BRPI0408893-0A 2003-04-04 2004-04-02 benzimidazóis cìclicos BRPI0408893A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03007780 2003-04-04
PCT/EP2004/050428 WO2004087701A1 (en) 2003-04-04 2004-04-02 Cyclic benzimidazoles

Publications (1)

Publication Number Publication Date
BRPI0408893A true BRPI0408893A (pt) 2006-04-11

Family

ID=33104052

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408893-0A BRPI0408893A (pt) 2003-04-04 2004-04-02 benzimidazóis cìclicos

Country Status (18)

Country Link
US (2) US7307084B2 (pt)
EP (1) EP1613626A1 (pt)
JP (1) JP2006522071A (pt)
KR (1) KR20060015483A (pt)
CN (1) CN100393720C (pt)
AR (1) AR043962A1 (pt)
AU (1) AU2004226180A1 (pt)
BR (1) BRPI0408893A (pt)
CA (1) CA2520581A1 (pt)
EA (1) EA200501537A1 (pt)
IS (1) IS8091A (pt)
MX (1) MXPA05010310A (pt)
NO (1) NO20055033L (pt)
NZ (1) NZ542177A (pt)
RS (1) RS20050730A (pt)
TW (1) TW200510410A (pt)
WO (1) WO2004087701A1 (pt)
ZA (1) ZA200506905B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR048869A1 (es) * 2004-04-26 2006-06-07 Altana Pharma Ag Bencimidazoles triciclicos
DE602005002751T2 (de) * 2004-06-09 2008-07-17 Nycomed Gmbh Substituierte tricyclische benzimidazole
EP1863820A1 (en) * 2005-03-24 2007-12-12 Nycomed GmbH Thioamide-substituted tricyclic benzimidazoles useful for the treatment of gastrointestinal diseases
AR057061A1 (es) * 2005-06-16 2007-11-14 Altana Pharma Ag Espiro-bencimidazoles farmaceuticamente activos y su uso en la fabricacion de medicamentos
WO2006136552A2 (en) * 2005-06-22 2006-12-28 Nycomed Gmbh Process for the production of intermadiates for the preparation of tricyclic benzimidazoles
WO2007072142A2 (en) * 2005-12-19 2007-06-28 Pfizer Japan Inc. Benzimidazole-5-carboxamide derivatives
ATE512969T1 (de) 2006-09-21 2011-07-15 Raqualia Pharma Inc Benzimidazolderivate als selektive säurepumpenhemmer
ES2365560T3 (es) * 2006-09-21 2011-10-06 Raqualia Pharma Inc Derivados de bencilmidazoles como inhibidores selectivos de bombas de ácido.
WO2008071765A1 (en) * 2006-12-14 2008-06-19 Nycomed Gmbh Pharmaceutically active spiro-substituted benzimidazole derivatives
WO2008074858A1 (en) * 2006-12-21 2008-06-26 Nycomed Gmbh Intermediates and process for the production of 5-substituted tricyclic benzimidazoles
WO2008095912A2 (en) * 2007-02-06 2008-08-14 Nycomed Gmbh Enantiopure pharmacologically active tricyclic benzimidazoles
WO2008114123A1 (en) * 2007-03-21 2008-09-25 Raqualia Pharma Inc. Spiro benzimidazole derivatives as acid pump inhibitors
WO2008151927A2 (en) * 2007-06-15 2008-12-18 Nycomed Gmbh 6-n-substituted benz imidazole derivatives as acid pump antagonists
EP2452680B1 (en) 2009-07-09 2019-12-18 RaQualia Pharma Inc. Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8604566D0 (sv) * 1986-10-27 1986-10-27 Haessle Ab Novel compunds
SE9401197D0 (sv) 1994-04-11 1994-04-11 Astra Ab Active compounds
SE9602286D0 (sv) 1996-06-10 1996-06-10 Astra Ab New compounds
MXPA04001277A (es) * 2001-08-10 2004-05-27 Altana Pharma Ag Imidazopiridinas triciclicas.
AR043063A1 (es) 2002-12-13 2005-07-13 Altana Pharma Ag Bencimidazoles 6-sustituidos y su uso como inhibidores de secreciones gastricas
AR046893A1 (es) * 2003-12-16 2005-12-28 Altana Pharma Ag Bencimidazoles triciclicos

Also Published As

Publication number Publication date
CN100393720C (zh) 2008-06-11
EA200501537A1 (ru) 2006-06-30
RS20050730A (sr) 2007-11-15
US20080113963A1 (en) 2008-05-15
TW200510410A (en) 2005-03-16
CN1764662A (zh) 2006-04-26
NO20055033L (no) 2005-10-28
AR043962A1 (es) 2005-08-17
WO2004087701A1 (en) 2004-10-14
KR20060015483A (ko) 2006-02-17
NZ542177A (en) 2009-02-28
WO2004087701A8 (en) 2005-03-03
US20060194968A1 (en) 2006-08-31
MXPA05010310A (es) 2005-11-17
AU2004226180A1 (en) 2004-10-14
IS8091A (is) 2005-10-26
ZA200506905B (en) 2007-01-31
EP1613626A1 (en) 2006-01-11
CA2520581A1 (en) 2004-10-14
US7307084B2 (en) 2007-12-11
HK1088898A1 (zh) 2006-11-17
JP2006522071A (ja) 2006-09-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 7A E 8A ANUIDADES.