BRPI0409376A - derivados de indeno como agentes farmacêuticos - Google Patents

derivados de indeno como agentes farmacêuticos

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Publication number
BRPI0409376A
BRPI0409376A BRPI0409376-3A BRPI0409376A BRPI0409376A BR PI0409376 A BRPI0409376 A BR PI0409376A BR PI0409376 A BRPI0409376 A BR PI0409376A BR PI0409376 A BRPI0409376 A BR PI0409376A
Authority
BR
Brazil
Prior art keywords
pharmaceutical agents
indene derivatives
compounds
indene
derivatives
Prior art date
Application number
BRPI0409376-3A
Other languages
English (en)
Inventor
Jeffery R Raymond
Hang Han
Yuanlin Zhou
Yuehua He
Bradley Noren
James Gee Ken Yee
Original Assignee
Inflazyme Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inflazyme Pharm Ltd filed Critical Inflazyme Pharm Ltd
Publication of BRPI0409376A publication Critical patent/BRPI0409376A/pt

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    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

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Abstract

"DERIVADOS DE INDENO COMO AGENTES FARMACêUTICOS". Compostos de fórmula (Ia) : nos quais R1, R2, R3, R4a, R4b, R5 e R6 são aqui definidos, assim como outros derivados de indeno são aqui divulgados. São também divulgadas composições farmacêuticas contendo os compostos e métodos para usar os compostos.
BRPI0409376-3A 2003-04-15 2004-04-15 derivados de indeno como agentes farmacêuticos BRPI0409376A (pt)

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US46321603P 2003-04-15 2003-04-15
PCT/CA2004/000566 WO2004092100A1 (en) 2003-04-15 2004-04-15 Indene derivatives as pharmaceutical agents

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BRPI0409376A true BRPI0409376A (pt) 2006-04-25

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EP (3) EP2277848B1 (pt)
JP (2) JP4956182B2 (pt)
KR (1) KR101239396B1 (pt)
CN (3) CN102001916B (pt)
AT (1) ATE498600T1 (pt)
AU (2) AU2004229598B2 (pt)
BR (1) BRPI0409376A (pt)
CA (1) CA2521883C (pt)
DE (1) DE602004031410D1 (pt)
ES (1) ES2359916T3 (pt)
MX (1) MXPA05011212A (pt)
NO (1) NO334964B1 (pt)
NZ (1) NZ542962A (pt)
RU (1) RU2381209C2 (pt)
WO (1) WO2004092100A1 (pt)

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CA2521883C (en) 2003-04-15 2013-09-17 Inflazyme Pharmaceuticals Ltd. Indene derivatives as pharmaceutical agents
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CA2839606A1 (en) 2011-07-22 2013-01-31 Venantius Limited Indene derivatives for use in the treatment of inflammatory bowel disease
WO2013174917A1 (en) * 2012-05-24 2013-11-28 Venantius Limited Compounds for use in the treatment of autoimmune inflammatory disease
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US20190047939A1 (en) * 2016-03-02 2019-02-14 Patheon Austria Gmbh & Co Kg Process and intermediates for the production of 17(20)-ene b-seco steroids
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WO2018126040A1 (en) 2016-12-28 2018-07-05 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol
CN112543753A (zh) * 2018-04-06 2021-03-23 塔罗制药公司 可用于治疗疼痛和炎症的茚衍生物
AU2019247496A1 (en) 2018-04-06 2020-10-22 Taro Pharmaceuticals Inc. Indene derivatives useful in treating pain and inflammation
ES2960542T3 (es) * 2018-04-06 2024-03-05 Taro Pharmaceuticals Inc Derivados de hexadecahidro-1H-ciclopenta[a]fenantreno útiles en el tratamiento del dolor y la inflamación
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CN110423261B (zh) * 2019-09-04 2021-09-14 成都百途医药科技有限公司 一种7-酮基石胆酸中间体及其制备工艺、应用
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US20050004086A1 (en) 2005-01-06
US20110172258A9 (en) 2011-07-14
US8673975B2 (en) 2014-03-18
DE602004031410D1 (de) 2011-03-31
CN102001916A (zh) 2011-04-06
EP1615866B1 (en) 2011-02-16
RU2005135439A (ru) 2006-05-27
KR101239396B1 (ko) 2013-03-05
CN102001916B (zh) 2016-03-30
US20110009439A1 (en) 2011-01-13
RU2381209C2 (ru) 2010-02-10
ATE498600T1 (de) 2011-03-15
NO20054787D0 (no) 2005-10-18
JP2011068677A (ja) 2011-04-07
AU2011200686A1 (en) 2011-03-10
AU2004229598B2 (en) 2011-01-20
US20100152220A1 (en) 2010-06-17
NO20054787L (no) 2005-11-14
NO334964B1 (no) 2014-08-11
NZ542962A (en) 2008-08-29
US20150307426A9 (en) 2015-10-29
WO2004092100A1 (en) 2004-10-28
EP1615866A1 (en) 2006-01-18
EP3156387B1 (en) 2018-07-25
ES2359916T3 (es) 2011-05-30
CN1805915A (zh) 2006-07-19
US8084503B2 (en) 2011-12-27
CA2521883C (en) 2013-09-17
AU2004229598A1 (en) 2004-10-28
JP5529000B2 (ja) 2014-06-25
JP4956182B2 (ja) 2012-06-20
KR20060017589A (ko) 2006-02-24
US20120270901A1 (en) 2012-10-25
WO2004092100A8 (en) 2005-05-19
MXPA05011212A (es) 2006-03-30
EP2277848B1 (en) 2016-09-14
US7999010B2 (en) 2011-08-16
AU2011200686B2 (en) 2012-02-02
CN102010298A (zh) 2011-04-13
US7601874B2 (en) 2009-10-13
EP3156387A1 (en) 2017-04-19
US20140371252A1 (en) 2014-12-18
CA2521883A1 (en) 2004-10-28
EP2277848A1 (en) 2011-01-26
HK1155146A1 (zh) 2012-05-11
JP2006523624A (ja) 2006-10-19

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