BRPI0409465A - derivados de carboxamida como agentes antidiabéticos - Google Patents

derivados de carboxamida como agentes antidiabéticos

Info

Publication number
BRPI0409465A
BRPI0409465A BRPI0409465-4A BRPI0409465A BRPI0409465A BR PI0409465 A BRPI0409465 A BR PI0409465A BR PI0409465 A BRPI0409465 A BR PI0409465A BR PI0409465 A BRPI0409465 A BR PI0409465A
Authority
BR
Brazil
Prior art keywords
antidiabetic agents
carboxamide derivatives
prodrugs
stereoisomers
compounds
Prior art date
Application number
BRPI0409465-4A
Other languages
English (en)
Inventor
Donald Louis Bussolotti
Ronald Bruce Gammill
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BRPI0409465A publication Critical patent/BRPI0409465A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"DERIVADOS DE CARBOXAMIDA COMO AGENTES ANTIDIABéTICOS". A presente invenção refere-se aos compostos de fórmula (I), os estereoisómeros e pró-drogas dos mesmos e os sais farmaceuticamente aceitáveis dos compostos, estereoisómeros e pró-drogas; em que R1, R2, Ra, Rb, X e Z são como aqui definidos; composições farmacêuticas dos mesmos; e uso dos mesmos.
BRPI0409465-4A 2003-04-17 2004-04-05 derivados de carboxamida como agentes antidiabéticos BRPI0409465A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46369103P 2003-04-17 2003-04-17
PCT/IB2004/001198 WO2004092158A1 (en) 2003-04-17 2004-04-05 Carboxamide derivatives as anti-diabetic agents

Publications (1)

Publication Number Publication Date
BRPI0409465A true BRPI0409465A (pt) 2006-05-02

Family

ID=33300085

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409465-4A BRPI0409465A (pt) 2003-04-17 2004-04-05 derivados de carboxamida como agentes antidiabéticos

Country Status (6)

Country Link
US (1) US6992092B2 (pt)
EP (1) EP1620427A1 (pt)
BR (1) BRPI0409465A (pt)
CA (1) CA2522225A1 (pt)
MX (1) MXPA05011176A (pt)
WO (1) WO2004092158A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0205170D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205166D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205176D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205162D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205175D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0222909D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
GB0222912D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
GB0321003D0 (en) * 2003-09-09 2003-10-08 Angeletti P Ist Richerche Bio Compounds, compositions and uses
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP2348857B1 (en) 2008-10-22 2016-02-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US8329914B2 (en) 2008-10-31 2012-12-11 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
JP2013520502A (ja) 2010-02-25 2013-06-06 メルク・シャープ・エンド・ドーム・コーポレイション 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体
SG192941A1 (en) 2011-02-25 2013-09-30 Merck Sharp & Dohme Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
RU2015106909A (ru) 2012-08-02 2016-09-27 Мерк Шарп И Доум Корп. Антидиабетические трициклические соединения
KR20150118158A (ko) 2013-02-22 2015-10-21 머크 샤프 앤드 돔 코포레이션 항당뇨병 비시클릭 화합물
WO2014139388A1 (en) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
CN105147677B (zh) * 2015-06-29 2019-01-25 中国医学科学院医药生物技术研究所 一组2-取代甲酰胺基-3-烷氧基吡啶类衍生物及其制药用途
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
EP3558298B1 (en) 2016-12-20 2026-03-11 Merck Sharp & Dohme LLC Antidiabetic spirochroman compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI974437A7 (fi) 1995-06-06 1997-12-05 Pfizer Substituoituja N-(indoli-2-karbonyyli)amideja ja johdannaisia glykogee nifosforylaasi-inhibiittoreina
DE69523182T2 (de) * 1995-06-06 2002-02-07 Pfizer Substituierte n-(indol-2-carbonyl)-glycinamide und derivate als glycogen phosphorylase inhibitoren
ATE257480T1 (de) 1999-09-30 2004-01-15 Pfizer Prod Inc Bicyclische pyrrolylamide als glycogenphosphorylase-inhibitoren
US6277877B1 (en) 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
GB0021831D0 (en) * 2000-09-06 2000-10-18 Astrazeneca Ab Chemical compounds
WO2003091213A1 (en) * 2002-04-25 2003-11-06 Yamanouchi Pharmaceutical Co., Ltd. Novel amide derivatives or salts thereof

Also Published As

Publication number Publication date
US6992092B2 (en) 2006-01-31
MXPA05011176A (es) 2005-12-14
WO2004092158A1 (en) 2004-10-28
US20040229916A1 (en) 2004-11-18
CA2522225A1 (en) 2004-10-28
EP1620427A1 (en) 2006-02-01

Similar Documents

Publication Publication Date Title
BRPI0409465A (pt) derivados de carboxamida como agentes antidiabéticos
ATE297203T1 (de) Antithrombotische mitteln
BRPI0412851A (pt) benzamidazóis de n-metila-substituìdos
DE60130771D1 (de) Substituierte heterocyclische amide
BRPI0417458A (pt) compostos inibidores de dpp-iv, sais faramaceuticamente aceitáveis e pró-fármacos do mesmo, seus processos de preparação, composição farmacêutica compreendendo os mesmos e uso dos referidos compostos na fabricação de medicamento
DE69919212D1 (de) Aromatische amiden
BR0316081A (pt) Derivados de 2-piridona como inibidores de elastase de neutrófilo
ATE326453T1 (de) Antithrombotische amide
DK2314582T3 (da) Heterocykliske forbindelser som antivirusmidler
BRPI0408353A (pt) composto, composição farmacêutica, métodos para o tratamento de neoplasias suscetìveis e para o tratamento de infecções virais, e, uso de um composto
ATE306261T1 (de) Antithrombosemittel
UY27333A1 (es) Nucleótidos 4` sustituidos
BR0314113A (pt) Derivados de amino propanol
BR0115580A (pt) Derivados de 3-aroilindol e a utilizaçao dos mesmos como agonistas dos receptores cb2
ATE260275T1 (de) Substituierte thien-3-yl- sulfonylamino(thio)carbonyl-triazolin(thi)one
BR0116571A (pt) Compostos heterocìclicos tendo atividade antibacteriana, processo para sua preparação e composições farmacêuticas contendo os mesmos
BR0212069A (pt) Agentes antidiabéticos orais
BRPI0409105A (pt) análogos de quinobenzoxazina substituìdos
DE69507293D1 (de) Benzamid-derivate als vasopressin-antagonisten
ATE440833T1 (de) Antithrombotische diamide
ES2187261A1 (es) Compuestos de eteres y amidas y su preparacion, como agentes anti-diabeticos.
PA8573501A1 (es) Derivados de benzoxazina y su empleo
MXPA05006889A (es) Compuestos aromaticos como agentes anti-inflamatorios, inmunomoduladores y anti-proliferativos.
BRPI0408204A (pt) derivados de quinolinona/benzoxazinona e usos dos mesmos
BRPI0416873A (pt) derivados de benzoxazina e usos dos mesmos

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired