BRPI0409465A - derivados de carboxamida como agentes antidiabéticos - Google Patents

derivados de carboxamida como agentes antidiabéticos

Info

Publication number
BRPI0409465A
BRPI0409465A BRPI0409465-4A BRPI0409465A BRPI0409465A BR PI0409465 A BRPI0409465 A BR PI0409465A BR PI0409465 A BRPI0409465 A BR PI0409465A BR PI0409465 A BRPI0409465 A BR PI0409465A
Authority
BR
Brazil
Prior art keywords
antidiabetic agents
carboxamide derivatives
prodrugs
stereoisomers
compounds
Prior art date
Application number
BRPI0409465-4A
Other languages
English (en)
Inventor
Donald Louis Bussolotti
Ronald Bruce Gammill
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BRPI0409465A publication Critical patent/BRPI0409465A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"DERIVADOS DE CARBOXAMIDA COMO AGENTES ANTIDIABéTICOS". A presente invenção refere-se aos compostos de fórmula (I), os estereoisómeros e pró-drogas dos mesmos e os sais farmaceuticamente aceitáveis dos compostos, estereoisómeros e pró-drogas; em que R1, R2, Ra, Rb, X e Z são como aqui definidos; composições farmacêuticas dos mesmos; e uso dos mesmos.
BRPI0409465-4A 2003-04-17 2004-04-05 derivados de carboxamida como agentes antidiabéticos BRPI0409465A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46369103P 2003-04-17 2003-04-17
PCT/IB2004/001198 WO2004092158A1 (en) 2003-04-17 2004-04-05 Carboxamide derivatives as anti-diabetic agents

Publications (1)

Publication Number Publication Date
BRPI0409465A true BRPI0409465A (pt) 2006-05-02

Family

ID=33300085

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409465-4A BRPI0409465A (pt) 2003-04-17 2004-04-05 derivados de carboxamida como agentes antidiabéticos

Country Status (6)

Country Link
US (1) US6992092B2 (pt)
EP (1) EP1620427A1 (pt)
BR (1) BRPI0409465A (pt)
CA (1) CA2522225A1 (pt)
MX (1) MXPA05011176A (pt)
WO (1) WO2004092158A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0205176D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205166D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205162D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205170D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205175D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0222909D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
GB0222912D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
GB0321003D0 (en) * 2003-09-09 2003-10-08 Angeletti P Ist Richerche Bio Compounds, compositions and uses
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP2348857B1 (en) 2008-10-22 2016-02-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
JP5557845B2 (ja) 2008-10-31 2014-07-23 メルク・シャープ・アンド・ドーム・コーポレーション 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体
AU2011218830B2 (en) 2010-02-25 2014-07-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
MX348131B (es) 2011-02-25 2017-05-26 Merck Sharp & Dohme Novedosos derivados de azabencimidazol ciclico utiles como agentes antidiabeticos.
WO2014022528A1 (en) 2012-08-02 2014-02-06 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2014130608A1 (en) 2013-02-22 2014-08-28 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
WO2014139388A1 (en) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
CN105147677B (zh) * 2015-06-29 2019-01-25 中国医学科学院医药生物技术研究所 一组2-取代甲酰胺基-3-烷氧基吡啶类衍生物及其制药用途
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
EP3558298B1 (en) 2016-12-20 2026-03-11 Merck Sharp & Dohme LLC Antidiabetic spirochroman compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3314938B2 (ja) 1995-06-06 2002-08-19 ファイザー・インコーポレーテッド グリコーゲンホスホリラーゼ抑制剤としての置換されたｎ−（インドール−２−カルボニル）−グリシンアミド類および誘導体
FI974437A0 (fi) * 1995-06-06 1997-12-05 Pfizer Substituoituja N-(indoli-2-karbonyyli)amideja ja johdannaisia glykogeenifosforylaasi-inhibiittoreina
DE60007592T2 (de) 1999-09-30 2004-09-16 Pfizer Products Inc., Groton Bicyclische Pyrrolylamide als Glycogenphosphorylase-Inhibitoren
US6277877B1 (en) 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
GB0021831D0 (en) * 2000-09-06 2000-10-18 Astrazeneca Ab Chemical compounds
JPWO2003091213A1 (ja) * 2002-04-25 2005-09-02 アステラス製薬株式会社 新規なアミド誘導体又はその塩

Also Published As

Publication number Publication date
WO2004092158A1 (en) 2004-10-28
EP1620427A1 (en) 2006-02-01
US20040229916A1 (en) 2004-11-18
MXPA05011176A (es) 2005-12-14
CA2522225A1 (en) 2004-10-28
US6992092B2 (en) 2006-01-31

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired