BRPI0409678A - métodos para identificar um composto, para tratar ou prevenir uma doença ou distúrbio em um humano, para incrementar a função de órgãos, tecidos, ou células excitáveis em um humano e para modular a atividade de um complexo de receptores de citocinas protetor de tecidos em um humano - Google Patents

métodos para identificar um composto, para tratar ou prevenir uma doença ou distúrbio em um humano, para incrementar a função de órgãos, tecidos, ou células excitáveis em um humano e para modular a atividade de um complexo de receptores de citocinas protetor de tecidos em um humano

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Publication number
BRPI0409678A
BRPI0409678A BRPI0409678-9A BRPI0409678A BRPI0409678A BR PI0409678 A BRPI0409678 A BR PI0409678A BR PI0409678 A BRPI0409678 A BR PI0409678A BR PI0409678 A BRPI0409678 A BR PI0409678A
Authority
BR
Brazil
Prior art keywords
human
tissues
excitable
cells
identifying
Prior art date
Application number
BRPI0409678-9A
Other languages
English (en)
Inventor
Michael Brines
Anthony Cerami
Pietro Ghezzi
Fabio Fiordaliso
Maddalena Fratelli
Marcel Leist
Mette Nielsen
Thomas Sager
Lars Ostergaard Pedersen
Jens Gerwien
Thomas Coleman
Original Assignee
Kenneth S Warren Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kenneth S Warren Inst Inc filed Critical Kenneth S Warren Inst Inc
Publication of BRPI0409678A publication Critical patent/BRPI0409678A/pt

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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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Abstract

"MéTODOS PARA IDENTIFICAR UM COMPOSTO, PARA TRATAR OU PREVENIR UMA DOENçA OU DISTúRBIO EM UM HUMANO, PARA INCREMENTAR A FUNçãO DE óRGãOS, TECIDOS, OU CéLULAS EXCITáVEIS EM UM HUMANO E PARA MODULAR A ATIVIDADE DE UM COMPLEXO DE RECEPTORES DE CITOCINAS PROTETOR DE TECIDOS EM UM HUMANO". A presente invenção refere-se a métodos para identificar compostos que apresentam uma atividade protetora de tecido utilizando-se complexo de receptores heteromultímero que media as atividades protetoras de tecido. O complexo consiste de pelo menos um EPO-R em complexo com pelo menos um receptor <225>~ c~. Estes compostos usados nos ensaios para identificar compostos protetores de tecido incluem, embora sem limitação, pequenas moléculas e biolócos. Os compostos identificados com o uso destes ensaios podem ser empregados para tratar ou prevenir várias doenças, distúrbios, ou condições dos sistemas nervosos central e periférico e também aquelas de outros órgãos, tecidos e células excitáveis ou responsivos à eritropoietina.
BRPI0409678-9A 2003-04-25 2004-04-26 métodos para identificar um composto, para tratar ou prevenir uma doença ou distúrbio em um humano, para incrementar a função de órgãos, tecidos, ou células excitáveis em um humano e para modular a atividade de um complexo de receptores de citocinas protetor de tecidos em um humano BRPI0409678A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46589103P 2003-04-25 2003-04-25
US10/676,694 US7718363B2 (en) 2003-04-25 2003-09-30 Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds
PCT/US2004/013099 WO2004096148A2 (en) 2003-04-25 2004-04-26 Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0409678A true BRPI0409678A (pt) 2006-05-02

Family

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BRPI0409678-9A BRPI0409678A (pt) 2003-04-25 2004-04-26 métodos para identificar um composto, para tratar ou prevenir uma doença ou distúrbio em um humano, para incrementar a função de órgãos, tecidos, ou células excitáveis em um humano e para modular a atividade de um complexo de receptores de citocinas protetor de tecidos em um humano

Country Status (13)

Country Link
US (2) US7718363B2 (pt)
EP (1) EP1622570A4 (pt)
JP (1) JP2006524827A (pt)
KR (1) KR20050121270A (pt)
AU (1) AU2004233985A1 (pt)
BR (1) BRPI0409678A (pt)
CA (1) CA2523578A1 (pt)
EA (1) EA009745B1 (pt)
IS (1) IS8075A (pt)
MX (1) MXPA05011134A (pt)
NO (1) NO20055525L (pt)
NZ (1) NZ543192A (pt)
WO (1) WO2004096148A2 (pt)

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IS8075A (is) 2005-10-14
EP1622570A4 (en) 2009-07-08
NO20055525L (no) 2006-01-16
NO20055525D0 (no) 2005-11-23
WO2004096148A2 (en) 2004-11-11
CA2523578A1 (en) 2004-11-11
EA009745B1 (ru) 2008-04-28
WO2004096148A3 (en) 2006-03-02
US20090136519A1 (en) 2009-05-28
EA200501667A1 (ru) 2006-06-30
JP2006524827A (ja) 2006-11-02
US7718363B2 (en) 2010-05-18
AU2004233985A1 (en) 2004-11-11
KR20050121270A (ko) 2005-12-26
US20040214236A1 (en) 2004-10-28
NZ543192A (en) 2008-07-31
MXPA05011134A (es) 2006-05-25

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