BRPI0409683A - 5-hidroxiindóis com grupos n-óxido e seu emprego como agentes terapêuticos - Google Patents

5-hidroxiindóis com grupos n-óxido e seu emprego como agentes terapêuticos

Info

Publication number
BRPI0409683A
BRPI0409683A BRPI0409683-5A BRPI0409683A BRPI0409683A BR PI0409683 A BRPI0409683 A BR PI0409683A BR PI0409683 A BRPI0409683 A BR PI0409683A BR PI0409683 A BRPI0409683 A BR PI0409683A
Authority
BR
Brazil
Prior art keywords
hydroxyindoles
therapeutic agents
oxide groups
compounds
phosphodiesterase
Prior art date
Application number
BRPI0409683-5A
Other languages
English (en)
Inventor
Norbert H Fgen
Hildegard Kuss
Karin Steinike
Ute Egerland
Chris Rundfeldt
Thomas Pfeifer
Original Assignee
Elbion Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elbion Ag filed Critical Elbion Ag
Publication of BRPI0409683A publication Critical patent/BRPI0409683A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
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    • A61P11/06—Antiasthmatics
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    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Emergency Medicine (AREA)
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  • AIDS & HIV (AREA)

Abstract

"5-HIDROXIINDóIS COM GRUPOS N-óXIDO E SEU EMPREGO COMO AGENTES TERAPêUTICOS". A invenção refere-se a 5-hidroxiindóis substituídas com grupos N-óxido, processo para sua preparação, preparados farmacêuticos que contêm esses compostos, assim como o emprego farmacêutico desses compostos, que são inibidores da fosfodiesterase 4, como substâncias ativas para tratamento de doenças que podem ser influenciadas pelos compostos de acordo com a invenção através de uma inibição da atividade da 4-fosfodiesterase, particularmente em células imunocompetentes (por exemplo macrófagos e linfócitos).
BRPI0409683-5A 2003-04-24 2004-04-23 5-hidroxiindóis com grupos n-óxido e seu emprego como agentes terapêuticos BRPI0409683A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10318609A DE10318609A1 (de) 2003-04-24 2003-04-24 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
PCT/EP2004/004340 WO2004094406A1 (de) 2003-04-24 2004-04-23 5-hydroxyindole mit n-oxidgruppen und deren verwendung als phosphodiesterase 4 hemmer

Publications (1)

Publication Number Publication Date
BRPI0409683A true BRPI0409683A (pt) 2006-04-18

Family

ID=33154391

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409683-5A BRPI0409683A (pt) 2003-04-24 2004-04-23 5-hidroxiindóis com grupos n-óxido e seu emprego como agentes terapêuticos

Country Status (16)

Country Link
US (1) US20040266760A1 (pt)
EP (1) EP1615911A1 (pt)
JP (1) JP2006524210A (pt)
KR (1) KR20060014035A (pt)
CN (1) CN1777599A (pt)
AR (1) AR044079A1 (pt)
AU (1) AU2004232484A1 (pt)
BR (1) BRPI0409683A (pt)
CA (1) CA2523062A1 (pt)
DE (1) DE10318609A1 (pt)
MX (1) MXPA05011435A (pt)
NO (1) NO20055518L (pt)
RU (1) RU2005136426A (pt)
TW (1) TW200505448A (pt)
WO (1) WO2004094406A1 (pt)
ZA (1) ZA200506764B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10318611A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE102004031538A1 (de) * 2004-06-29 2006-02-09 Baxter International Inc., Deerfield Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit
US20060110462A1 (en) * 2004-11-08 2006-05-25 Pavlos Papadopoulos Nanoparticulate compositions of tubulin inhibitor compounds
EP2049520A4 (en) * 2006-08-07 2011-01-05 Ironwood Pharmaceuticals Inc indole compounds
AU2007325797B2 (en) * 2006-11-28 2014-03-13 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
MD3762368T2 (ro) 2018-03-08 2022-07-31 Incyte Corp Compuși diol aminopirazină ca inhibitori ai PI3K-Y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DE59913617D1 (de) * 1998-04-28 2006-08-03 Elbion Ag Indolderivate und deren Verwendung als Inhibitoren der Phosphodiesterase 4.
DE19818964A1 (de) * 1998-04-28 1999-11-04 Dresden Arzneimittel Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
DE10253426B4 (de) * 2002-11-15 2005-09-22 Elbion Ag Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
ZA200506764B (en) 2006-07-26
NO20055518L (no) 2006-01-18
CA2523062A1 (en) 2004-11-04
CN1777599A (zh) 2006-05-24
WO2004094406A1 (de) 2004-11-04
AU2004232484A1 (en) 2004-11-04
JP2006524210A (ja) 2006-10-26
DE10318609A1 (de) 2004-11-11
AR044079A1 (es) 2005-08-24
RU2005136426A (ru) 2006-03-20
KR20060014035A (ko) 2006-02-14
MXPA05011435A (es) 2005-12-12
TW200505448A (en) 2005-02-16
EP1615911A1 (de) 2006-01-18
NO20055518D0 (no) 2005-11-22
US20040266760A1 (en) 2004-12-30

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