BRPI0409741A - método para a preparação de complexos moleculares - Google Patents

método para a preparação de complexos moleculares

Info

Publication number
BRPI0409741A
BRPI0409741A BRPI0409741-6A BRPI0409741A BRPI0409741A BR PI0409741 A BRPI0409741 A BR PI0409741A BR PI0409741 A BRPI0409741 A BR PI0409741A BR PI0409741 A BRPI0409741 A BR PI0409741A
Authority
BR
Brazil
Prior art keywords
molecular complexes
preparation
molecular
recovered
consist
Prior art date
Application number
BRPI0409741-6A
Other languages
English (en)
Inventor
Hubert Lochard
Martial Sauceau
Bernard Freiss
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of BRPI0409741A publication Critical patent/BRPI0409741A/pt
Publication of BRPI0409741B1 publication Critical patent/BRPI0409741B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

"MéTODO PARA A PREPARAçãO DE COMPLEXOS MOLECULARES". A presente invenção refere-se a um método para a preparação de complexos moleculares solúveis, compreendendo uma ou mais substâncias ativas as quais são fracamente solúveis em um meio aquoso, incluídas dentro de uma ou mais moléculas hospedeiras, caracterizado por compreender as seguintes etapas: (a) pór uma ou mais substâncias ativas em contato com uma ou mais moléculas hospedeiras, (b) realizar uma etapa de difusão molecular pondo um fluido denso em contato, sob pressão, com a mistura obtida em (a), em modo estático, na presença de um ou mais agentes de difusão e (c) recuperação do complexo molecular formado deste modo.
BRPI0409741A 2003-04-25 2004-04-23 método para a preparação de complexos moleculares BRPI0409741B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0305140A FR2854079B1 (fr) 2003-04-25 2003-04-25 Procede de preparation de complexes moleculaires
PCT/FR2004/000995 WO2004096284A1 (fr) 2003-04-25 2004-04-23 Procede de preparation de complexes moleculaires

Publications (2)

Publication Number Publication Date
BRPI0409741A true BRPI0409741A (pt) 2006-05-09
BRPI0409741B1 BRPI0409741B1 (pt) 2016-12-06

Family

ID=33104420

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409741A BRPI0409741B1 (pt) 2003-04-25 2004-04-23 método para a preparação de complexos moleculares

Country Status (22)

Country Link
US (1) US8741346B2 (pt)
EP (2) EP2289561A1 (pt)
JP (1) JP5037936B2 (pt)
KR (1) KR101208256B1 (pt)
CN (1) CN100594941C (pt)
AT (1) ATE555811T1 (pt)
AU (1) AU2004233621B2 (pt)
BR (1) BRPI0409741B1 (pt)
CA (1) CA2523342C (pt)
DK (1) DK1638609T3 (pt)
ES (1) ES2386437T3 (pt)
FR (1) FR2854079B1 (pt)
IL (1) IL171520A (pt)
MX (1) MXPA05011505A (pt)
NO (1) NO335160B1 (pt)
NZ (1) NZ543209A (pt)
PL (1) PL1638609T3 (pt)
PT (1) PT1638609E (pt)
RU (2) RU2353392C2 (pt)
SI (1) SI1638609T1 (pt)
WO (1) WO2004096284A1 (pt)
ZA (1) ZA200508469B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE504316T1 (de) * 2004-04-01 2011-04-15 Pf Medicament Einschlusskomplexe enthaltend piroxicam, ein cyklodextrin und arginin
FR2876911B1 (fr) * 2004-10-21 2007-04-13 Pierre Fabre Medicament Sa Complexe comprenant du piroxicam, une cyclodextrine et de l'arginine
FR2876914A1 (fr) * 2004-10-21 2006-04-28 Pierre Fabre Medicament Sa Complexe comprenant un antibiotique, une cyclodextrine et un agent d'interaction
FR2876910B1 (fr) * 2004-10-21 2007-04-13 Pierre Fabre Medicament Sa Complexe comprenant la mequitazine, une cyclodextrine et un agent d'interaction
FR2944280B1 (fr) * 2009-04-09 2012-08-03 Galderma Res & Dev Procede de preparation de complexes moleculaires entre adapalene et des cyclodextrines
FR2944207B1 (fr) * 2009-04-09 2011-05-06 Galderma Res & Dev Compositions comprenant au moins un complexe compose d'un derive d'acide naphtoique et d'au moins une cyclodestrine et leurs utilisations
FR2944278B1 (fr) * 2009-04-09 2011-11-18 Pf Medicament Procede de preparation de complexes moleculaires entre un agent retinoide et des cyclodextrines
JP5622187B2 (ja) * 2009-09-08 2014-11-12 群泰生物科技股▲ふん▼有限公司 水溶性ミノキシジル組成物
US10328152B2 (en) 2011-06-16 2019-06-25 Nayan Patel Method for stabilization and delivery of therapeutic molecules
GB201609222D0 (en) 2016-05-25 2016-07-06 F2G Ltd Pharmaceutical formulation
US10532102B2 (en) 2016-08-19 2020-01-14 Foresee Pharmaceuticals Co., Ltd. Pharmaceutical composition and methods of uses
US11819503B2 (en) 2019-04-23 2023-11-21 F2G Ltd Method of treating coccidioides infection
IL292377B2 (en) * 2019-10-21 2023-11-01 Esolate Ltd Thin compounds and their production

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GB2191715B (en) 1986-06-17 1990-07-25 Midrex Int Bv Method and apparatus for dedusting and desulfurizing gases
JPH0677511B2 (ja) 1986-12-05 1994-10-05 金印わさび株式会社 香辛成分の包接化合物の製造方法
US4822497A (en) * 1987-09-22 1989-04-18 Modar, Inc. Method for solids separation in a wet oxidation type process
DE3744329A1 (de) * 1987-12-28 1989-07-06 Schwarz Pharma Gmbh Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung
FR2629735B1 (fr) * 1988-04-11 1991-03-22 Agronomique Inst Nat Rech Procede d'extraction au dioxyde de carbone supercritique de composes volatils, et composes obtenus
RU2108109C1 (ru) * 1990-10-04 1998-04-10 Мадаус АГ Способ получения комплекса силибинина с циклодекстрином, комплекс включения силибинина с циклодекстрином, фармацевтическая композиция антигепатотоксической активности и способ ее получения
GB9100643D0 (en) 1991-01-11 1991-02-27 Shaffery Michael J Filter system
JP3043085B2 (ja) * 1991-03-18 2000-05-22 日本たばこ産業株式会社 包接化合物の製造方法
US5389263A (en) * 1992-05-20 1995-02-14 Phasex Corporation Gas anti-solvent recrystallization and application for the separation and subsequent processing of RDX and HMX
EP0687174B1 (en) * 1993-03-05 2001-06-13 Hexal Ag Crystalline cyclodextrin inclusion complexes of ranitidine hydrochloride and process for their preparation
DE59406065D1 (de) * 1993-03-24 1998-07-02 Ciba Geigy Ag Verfahren zur Herstellung einer Liposomendispersion im Hochdruckbereich
GB9313642D0 (en) 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
EP0706821A1 (en) 1994-10-06 1996-04-17 Centre De Microencapsulation Method of coating particles
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
FR2741619B1 (fr) * 1995-11-28 1998-02-13 Pf Medicament Nouveaux derives de 2,3,5-trimethyl-4-hydroxy-anilides, leur preparation et leur application en therapeutique
AU709384B2 (en) 1996-03-01 1999-08-26 University Of Kansas, The Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
FR2753639B1 (fr) * 1996-09-25 1998-12-11 Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede
US5766637A (en) 1996-10-08 1998-06-16 University Of Delaware Microencapsulation process using supercritical fluids
DE19711393C1 (de) 1997-03-19 1998-08-13 Fraunhofer Ges Forschung Verfahren zum Mikroverkapseln von Partikeln
GB9800936D0 (en) * 1997-05-10 1998-03-11 Univ Nottingham Biofunctional polymers
IT1296464B1 (it) 1997-11-19 1999-06-25 Vectorpharma Int Composizioni farmaceutiche in forma di polveri di polimeri reticolati caricati con farmaci e relativo processo di preparazione mediante
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FR2798863B1 (fr) 1999-09-27 2001-12-28 Separex Sa Procede et installation de mise a l'etat adsorbe sur un support poreux de composes actifs contenus dans un produit
FR2799984B1 (fr) 1999-10-21 2002-05-03 Lavipharm Procede de fractionnement d'une matiere composee de plusieurs constituants a l'aide d'un solvant a pression supercritique
FR2803538B1 (fr) * 1999-12-15 2002-06-07 Separex Sa Procede et dispositif de captage de fines particules par percolation dans un lit de granules
FR2815540B1 (fr) * 2000-10-19 2005-06-10 Separex Sa Procede de fabrication de tres fines particules constituees d'un principe insere dans une molecule hote
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FR2823207B1 (fr) * 2001-04-10 2004-12-03 Pf Medicament Complexes d'anilides a chaine polycarbonee et de cyclodestrines, leur preparation et leur application en tant que medicamment en particulier pour le traitement des dislipidemies
FR2830761B1 (fr) * 2001-10-12 2003-12-12 Pf Medicament Procede de preparation d'un compose d'interaction d'un derive anilide avec un support poreux par fluide supercritique
FR2830760B1 (fr) * 2001-10-12 2004-06-04 Pf Medicament Procede de preparation d'un compose d'interaction de substances actives avec un support poreux par fluide supercritique

Also Published As

Publication number Publication date
CA2523342A1 (fr) 2004-11-11
US20060246140A1 (en) 2006-11-02
ES2386437T3 (es) 2012-08-21
NZ543209A (en) 2008-03-28
AU2004233621B2 (en) 2009-11-19
US8741346B2 (en) 2014-06-03
PL1638609T3 (pl) 2012-09-28
DK1638609T3 (da) 2012-08-20
WO2004096284A1 (fr) 2004-11-11
EP1638609B1 (fr) 2012-05-02
NO20055467L (no) 2005-11-18
HK1082430A1 (en) 2006-06-09
NO335160B1 (no) 2014-10-06
ATE555811T1 (de) 2012-05-15
JP2006524670A (ja) 2006-11-02
RU2005136664A (ru) 2006-03-10
CN100594941C (zh) 2010-03-24
MXPA05011505A (es) 2005-12-15
SI1638609T1 (sl) 2012-09-28
FR2854079B1 (fr) 2007-11-30
KR20060011974A (ko) 2006-02-06
EP2289561A1 (fr) 2011-03-02
FR2854079A1 (fr) 2004-10-29
CN1795014A (zh) 2006-06-28
BRPI0409741B1 (pt) 2016-12-06
JP5037936B2 (ja) 2012-10-03
PT1638609E (pt) 2012-07-24
RU2353392C2 (ru) 2009-04-27
KR101208256B1 (ko) 2012-12-05
CA2523342C (fr) 2012-12-04
ZA200508469B (en) 2006-07-26
AU2004233621A1 (en) 2004-11-11
IL171520A (en) 2011-07-31
RU2008137041A (ru) 2010-03-20
EP1638609A1 (fr) 2006-03-29

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/12/2016, OBSERVADAS AS CONDICOES LEGAIS.

B15K Others concerning applications: alteration of classification

Ipc: B82Y 5/00 (2011.01), A61K 47/69 (2017.01)

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 16A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: REFERENTE AO DESPACHO 21.6 PUBLICADO NA RPI 2563 DE 2020-02-18