BRPI0410239A - composto de 4-(2-furoil)aminopiperidina e medicamento - Google Patents

composto de 4-(2-furoil)aminopiperidina e medicamento

Info

Publication number
BRPI0410239A
BRPI0410239A BRPI0410239-8A BRPI0410239A BRPI0410239A BR PI0410239 A BRPI0410239 A BR PI0410239A BR PI0410239 A BRPI0410239 A BR PI0410239A BR PI0410239 A BRPI0410239 A BR PI0410239A
Authority
BR
Brazil
Prior art keywords
pyridylmethyl
mesityl
alkyl
following general
caused
Prior art date
Application number
BRPI0410239-8A
Other languages
English (en)
Inventor
Yukiko Muraki
Tomokazu Fujimoto
Takuya Kishimoto
Original Assignee
Kyorin Seiyaku Kk
Nisshin Seifun Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk, Nisshin Seifun Group Inc filed Critical Kyorin Seiyaku Kk
Publication of BRPI0410239A publication Critical patent/BRPI0410239A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"COMPOSTO DE 4-(2-FUROIL)AMINOPIPERIDINA E MEDICAMENTO". A invenção refere-se a compostos representados pela seguinte fórmula geral (I): ¢na qual R¬ 1¬ é 5-metilpiridin-2-ila, p-tolila ou mesitila, R¬ 2¬ é uma das seguintes fórmulas gerais (II) - (IX): (nas quais R¬ 3¬ é C1-C4-alquila, R¬ 4¬ é H ou C1-C4-alquila, R¬ 5¬ é H, 3-piridilmetila ou 4-piridilmetila, e R¬ 6¬ é 2,4-dihidroxibenzila, 3-piridilmetila ou 4-piridilmetil), ou quando R¬ 1¬ é mesitila, R¬ 2¬ é a seguinte fórmula (X)!, e sais farmaceuticamente aceitáveis dos mesmos. Os compostos apresentam ação inibidora de prurido, e são úteis para prevenção ou tratamento de coceira e prurido causado por reação contra ferimentos causados por insetos, reação contra agentes alergênicos do ambiente, infecções de pele ou infecções de parasitas externos, ou causadas a pacientes de diálise renal.
BRPI0410239-8A 2003-05-08 2004-05-06 composto de 4-(2-furoil)aminopiperidina e medicamento BRPI0410239A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003130634 2003-05-08
PCT/JP2004/006421 WO2004099194A1 (ja) 2003-05-08 2004-05-06 掻痒治療薬として有用な４－（２－フロイル）アミノピペリジン類

Publications (1)

Publication Number Publication Date
BRPI0410239A true BRPI0410239A (pt) 2006-05-16

Family

ID=33432110

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410239-8A BRPI0410239A (pt) 2003-05-08 2004-05-06 composto de 4-(2-furoil)aminopiperidina e medicamento

Country Status (9)

Country Link
US (1) US7601843B2 (pt)
EP (2) EP1621538A4 (pt)
JP (1) JP4009303B2 (pt)
KR (1) KR101160858B1 (pt)
CN (1) CN100582103C (pt)
BR (1) BRPI0410239A (pt)
CA (1) CA2524498C (pt)
MX (1) MXPA05012007A (pt)
WO (1) WO2004099194A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2769B1 (en) 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
JO2642B1 (en) 2006-12-08 2012-06-17 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
US7842616B2 (en) * 2007-01-22 2010-11-30 Advanced Technology Development Facility, Inc. Methods for fabricating semiconductor structures
JO2849B1 (en) 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
WO2008128996A1 (en) 2007-04-23 2008-10-30 Janssen Pharmaceutica N.V. Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
KR20100016498A (ko) * 2007-04-23 2010-02-12 얀센 파마슈티카 엔.브이. 속해리성 도파민 2 수용체 길항제로서의 피리딘 유도체
JP5431305B2 (ja) 2007-04-23 2014-03-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体
EP2310374B1 (en) 2008-07-03 2012-10-31 Janssen Pharmaceutica N.V. Substituted 6- (1-piperazinyl) -pyridazines as 5-ht6 receptor antagonists
EP2307374B1 (en) 2008-07-31 2017-01-25 Janssen Pharmaceutica NV Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4584303A (en) * 1984-04-09 1986-04-22 The Boc Group, Inc. N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds
US4667773A (en) * 1986-06-27 1987-05-26 Tonnie Davis Portable tree stand
US4791112A (en) * 1987-02-02 1988-12-13 The Boc Group, Inc. N-heterocyclic-N-(4-piperidyl)amides and pharmaceutical compositions and methods employing such compounds
US5567773A (en) 1995-04-04 1996-10-22 Mobil Oil Corporation Cold sealable cohesive polymers
US5667773A (en) 1996-03-12 1997-09-16 Adolor Corporation Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith
US5888494A (en) 1996-03-12 1999-03-30 Adolor Corporation Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic and pruritic conditions therewith
US5798093A (en) 1997-03-14 1998-08-25 Adolor Corporation Spray formulations of antihyperalgesic opiates and method of treating topical hyperalgesic conditions and pruritus therewith
US5811078A (en) 1997-03-14 1998-09-22 Adolor Corporation Spray formulations of antihyperalgesic opiates and method of treating topical hyperalgesic conditions therewith
GB9912417D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
EP1443046B1 (en) 2001-10-09 2008-12-17 Kyorin Pharmaceutical Co., Ltd. Novel 4-(2furoyl)aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same

Also Published As

Publication number Publication date
CA2524498A1 (en) 2004-11-18
CN1784398A (zh) 2006-06-07
JPWO2004099194A1 (ja) 2006-07-13
EP2325183A1 (en) 2011-05-25
EP1621538A1 (en) 2006-02-01
US7601843B2 (en) 2009-10-13
CA2524498C (en) 2012-01-24
MXPA05012007A (es) 2006-05-31
KR20060014039A (ko) 2006-02-14
CN100582103C (zh) 2010-01-20
WO2004099194A1 (ja) 2004-11-18
KR101160858B1 (ko) 2012-07-02
EP1621538A4 (en) 2009-07-29
US20060270632A1 (en) 2006-11-30
JP4009303B2 (ja) 2007-11-14

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014.