BRPI0411316A - uso de uma toxina clostrìdica para reduzir o apetite - Google Patents
uso de uma toxina clostrìdica para reduzir o apetiteInfo
- Publication number
- BRPI0411316A BRPI0411316A BRPI0411316-0A BRPI0411316A BRPI0411316A BR PI0411316 A BRPI0411316 A BR PI0411316A BR PI0411316 A BRPI0411316 A BR PI0411316A BR PI0411316 A BRPI0411316 A BR PI0411316A
- Authority
- BR
- Brazil
- Prior art keywords
- clostridial toxin
- reduce appetite
- appetite
- toxin
- reduce
- Prior art date
Links
- 230000036528 appetite Effects 0.000 title abstract 3
- 235000019789 appetite Nutrition 0.000 title abstract 3
- 231100001102 clostridial toxin Toxicity 0.000 title abstract 2
- 108030001720 Bontoxilysin Proteins 0.000 abstract 1
- 229940053031 botulinum toxin Drugs 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
"USO DE UMA TOXINA CLOSTRìDICA PARA REDUZIR O APETITE". A presente invenção refere-se a métodos para reduzir o apetite pela administração oral de uma toxina clostrídica, tal como toxina botulínica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/459,767 US20040253274A1 (en) | 2003-06-11 | 2003-06-11 | Use of a clostridial toxin to reduce appetite |
| PCT/US2004/017958 WO2005000343A1 (en) | 2003-06-11 | 2004-06-07 | Use of a clostridial toxin to reduce appetite |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0411316A true BRPI0411316A (pt) | 2006-07-18 |
Family
ID=33510866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0411316-0A BRPI0411316A (pt) | 2003-06-11 | 2004-06-07 | uso de uma toxina clostrìdica para reduzir o apetite |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20040253274A1 (pt) |
| EP (1) | EP1633393A1 (pt) |
| JP (1) | JP2007501285A (pt) |
| AU (1) | AU2004251708A1 (pt) |
| BR (1) | BRPI0411316A (pt) |
| CA (1) | CA2529010A1 (pt) |
| WO (1) | WO2005000343A1 (pt) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040226556A1 (en) | 2003-05-13 | 2004-11-18 | Deem Mark E. | Apparatus for treating asthma using neurotoxin |
| US7514088B2 (en) * | 2005-03-15 | 2009-04-07 | Allergan, Inc. | Multivalent Clostridial toxin derivatives and methods of their use |
| US7811584B2 (en) | 2004-06-30 | 2010-10-12 | Allergan, Inc. | Multivalent clostridial toxins |
| EP1982997B1 (en) | 2004-09-01 | 2012-08-08 | Allergan, Inc. | Degradable clostridial toxins |
| CA2518650A1 (en) * | 2004-09-10 | 2006-03-10 | Dimitrios Dimitrakoudis | Clostridium botulinum toxin formulation and method for reducing weight |
| US20060073208A1 (en) * | 2004-10-01 | 2006-04-06 | Allergan, Inc. | Cosmetic neurotoxin compositions and methods |
| CA2601592A1 (en) | 2005-03-15 | 2006-09-28 | Allergan, Inc. | Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems |
| JP5826450B2 (ja) | 2005-07-22 | 2015-12-02 | ザ ファウンドリー, エルエルシー | 治療薬の送達のためのシステムおよび方法 |
| US10052465B2 (en) | 2005-07-22 | 2018-08-21 | The Foundry, Llc | Methods and systems for toxin delivery to the nasal cavity |
| US9511210B2 (en) * | 2006-05-19 | 2016-12-06 | The Foundry, Llc | Apparatus for toxin delivery to the nasal cavity |
| US12433837B2 (en) | 2005-07-22 | 2025-10-07 | The Foundry, Llc | Systems and methods for delivery of a therapeutic agent |
| US7794386B2 (en) * | 2006-03-15 | 2010-09-14 | Allergan, Inc. | Methods for facilitating weight loss |
| US20080092910A1 (en) * | 2006-10-18 | 2008-04-24 | Allergan, Inc. | Apparatus and method for treating obesity using neurotoxins in conjunction with bariatric procedures |
| US20090149831A1 (en) * | 2007-12-05 | 2009-06-11 | Goldi Kaul | Polymeric Microspheres for Treatment of Obesity |
| US8483831B1 (en) | 2008-02-15 | 2013-07-09 | Holaira, Inc. | System and method for bronchial dilation |
| KR101719824B1 (ko) | 2008-05-09 | 2017-04-04 | 호라이라 인코포레이티드 | 기관지나무 치료용 시스템, 어셈블리 및 방법 |
| WO2011041483A2 (en) * | 2009-09-30 | 2011-04-07 | Toxcure, Inc. | Use of botulinum neurotoxin to treat substance addictions |
| CN107049479B (zh) | 2009-10-27 | 2020-10-16 | 努瓦拉公司 | 具有可冷却的能量发射组件的递送装置 |
| CN106618731B (zh) | 2009-11-11 | 2020-08-07 | 努瓦拉公司 | 用于处理组织和控制狭窄的系统、装置和方法 |
| US8911439B2 (en) | 2009-11-11 | 2014-12-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
| US9005628B2 (en) | 2012-10-04 | 2015-04-14 | Dublin City University | Biotherapy for pain |
| US9398933B2 (en) | 2012-12-27 | 2016-07-26 | Holaira, Inc. | Methods for improving drug efficacy including a combination of drug administration and nerve modulation |
| GB201312317D0 (en) | 2013-07-09 | 2013-08-21 | Syntaxin Ltd | Cationic neurotoxins |
| US9216210B2 (en) | 2013-12-23 | 2015-12-22 | Dublin City University | Multiprotease therapeutics for chronic pain |
| GB201517450D0 (en) | 2015-10-02 | 2015-11-18 | Ipsen Biopharm Ltd | Method |
| GB201607901D0 (en) | 2016-05-05 | 2016-06-22 | Ipsen Biopharm Ltd | Chimeric neurotoxins |
| EP3263710A1 (en) | 2016-07-01 | 2018-01-03 | Ipsen Biopharm Limited | Production of activated clostridial neurotoxins |
| EP3519430A1 (en) | 2016-09-29 | 2019-08-07 | Ipsen Biopharm Limited | Hybrid neurotoxins |
| US20210187194A1 (en) | 2018-02-26 | 2021-06-24 | Ipsen Biopharm Limited | Use of Ultrasound to Guide Injection of Non-cytotoxic Protease |
| GB201906835D0 (en) * | 2019-05-15 | 2019-06-26 | Ucb Biopharma Sprl | Dry microparticles |
| GB202103372D0 (en) | 2021-03-11 | 2021-04-28 | Ipsen Biopharm Ltd | Modified clostridial neurotoxins |
| US20250064906A1 (en) * | 2021-11-23 | 2025-02-27 | AEON Biopharma, Inc. | Neurotoxin compositions for use in treating digestive disorders |
| GB202318884D0 (en) | 2023-12-11 | 2024-01-24 | Ipsen Biopharm Ltd | Formulation |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL137652C (pt) * | 1962-07-11 | |||
| BE744162A (fr) * | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
| DE2010115A1 (de) * | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
| US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
| US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
| GB9120306D0 (en) * | 1991-09-24 | 1991-11-06 | Graham Herbert K | Method and compositions for the treatment of cerebral palsy |
| US5562907A (en) * | 1993-05-14 | 1996-10-08 | Arnon; Stephen S. | Method to prevent side-effects and insensitivity to the therapeutic uses of toxins |
| US5437291A (en) * | 1993-08-26 | 1995-08-01 | Univ Johns Hopkins | Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction |
| US5427291A (en) * | 1993-09-21 | 1995-06-27 | Smith; David S. | Ski carrier and method employing same |
| US6974578B1 (en) * | 1993-12-28 | 2005-12-13 | Allergan, Inc. | Method for treating secretions and glands using botulinum toxin |
| US6129685A (en) * | 1994-02-09 | 2000-10-10 | The University Of Iowa Research Foundation | Stereotactic hypothalamic obesity probe |
| US5766605A (en) * | 1994-04-15 | 1998-06-16 | Mount Sinai School Of Medicine Of The City University Of New York | Treatment of autonomic nerve dysfunction with botulinum toxin |
| US5670484A (en) * | 1994-05-09 | 1997-09-23 | Binder; William J. | Method for treatment of skin lesions associated with cutaneous cell-proliferative disorders |
| EP1086702B1 (en) * | 1994-05-09 | 2005-04-13 | BINDER, William J. | Presynaptic neurotoxins for treatment of migraine headache |
| GB9508204D0 (en) * | 1995-04-21 | 1995-06-07 | Speywood Lab Ltd | A novel agent able to modify peripheral afferent function |
| US6087129A (en) * | 1996-01-19 | 2000-07-11 | Betagene, Inc. | Recombinant expression of proteins from secretory cell lines |
| DE19715794C1 (de) * | 1997-04-16 | 1998-12-03 | Roehm Gmbh | Laminare Arzneiform und Verfahren zu ihrer Herstellung |
| EP1658858B2 (en) * | 1997-07-15 | 2014-03-26 | The Regents of the University of Colorado | Use of botulinum toxin for the treatment of recalcitrant voiding dysfunction |
| US6063768A (en) * | 1997-09-04 | 2000-05-16 | First; Eric R. | Application of botulinum toxin to the management of neurogenic inflammatory disorders |
| US6051239A (en) * | 1997-10-20 | 2000-04-18 | Thomas Jefferson University | Compositions and methods for systemic delivery of oral vaccines and therapeutic agents |
| EP1053014A4 (en) * | 1998-01-26 | 2004-11-10 | Univ Massachusetts | BIOLOGICALLY ACTIVE HEMAGGLUTININE TYPE A i (STRIDIUM BOTULINUM) AND METHOD FOR ITS USE |
| US6113915A (en) * | 1999-10-12 | 2000-09-05 | Allergan Sales, Inc. | Methods for treating pain |
| US6265379B1 (en) * | 1999-10-13 | 2001-07-24 | Allergan Sales, Inc. | Method for treating otic disorders |
| US6139845A (en) * | 1999-12-07 | 2000-10-31 | Allergan Sales, Inc. | Method for treating cancer with a neurotoxin |
| US6143306A (en) * | 2000-01-11 | 2000-11-07 | Allergan Sales, Inc. | Methods for treating pancreatic disorders |
| US6773711B2 (en) * | 2000-02-15 | 2004-08-10 | Allergan, Inc. | Botulinum toxin therapy for Hashimoto's thyroiditis |
| US6358513B1 (en) * | 2000-02-15 | 2002-03-19 | Allergan Sales, Inc. | Method for treating Hashimoto's thyroiditis |
| US6649161B1 (en) * | 2000-02-22 | 2003-11-18 | Allergan, Inc. | Method for treating hypocalcemia |
| US6464986B1 (en) * | 2000-04-14 | 2002-10-15 | Allegan Sales, Inc. | Method for treating pain by peripheral administration of a neurotoxin |
| US6299893B1 (en) * | 2000-04-17 | 2001-10-09 | Marvin Schwartz | Method to reduce hair loss and stimulate hair regrowth |
| AU2001259056A1 (en) * | 2000-05-17 | 2001-11-26 | Eli Lilly And Company | Method for selectively inhibiting ghrelin action |
| US6306423B1 (en) * | 2000-06-02 | 2001-10-23 | Allergan Sales, Inc. | Neurotoxin implant |
| US6306403B1 (en) * | 2000-06-14 | 2001-10-23 | Allergan Sales, Inc. | Method for treating parkinson's disease with a botulinum toxin |
| WO2002000172A2 (en) * | 2000-06-28 | 2002-01-03 | Ira Sanders | Methods for using tetanus toxin for benificial purposes in animals (mammals) |
| WO2002013854A1 (en) * | 2000-08-11 | 2002-02-21 | Temple University Of The Commonwealth System Of Higher Education | Obesity controlling method |
| US7737109B2 (en) * | 2000-08-11 | 2010-06-15 | Temple University Of The Commonwealth System Of Higher Education | Obesity controlling method |
| US6423319B1 (en) * | 2000-10-04 | 2002-07-23 | Allergan Sales, Inc. | Methods for treating muscle injuries |
| US6827931B1 (en) * | 2000-10-20 | 2004-12-07 | Allergan, Inc. | Method for treating endocrine disorders |
| EP1385879A4 (en) * | 2001-05-10 | 2005-02-02 | Univ Queensland | DIAGNOSIS AND THERAPY OF CANCER OF REPRODUCTIVE ORGANS |
| US6558400B2 (en) * | 2001-05-30 | 2003-05-06 | Satiety, Inc. | Obesity treatment tools and methods |
| US20050152905A1 (en) * | 2002-08-22 | 2005-07-14 | Omoigui Osemwota S. | Method of biochemical treatment of persistent pain |
| US7238357B2 (en) * | 2002-11-05 | 2007-07-03 | Allergan, Inc. | Methods for treating ulcers and gastroesophageal reflux disease |
| US20040086532A1 (en) * | 2002-11-05 | 2004-05-06 | Allergan, Inc., | Botulinum toxin formulations for oral administration |
| US20040115727A1 (en) * | 2002-12-11 | 2004-06-17 | Allergan, Inc., A Corporation | Evolved clostridial toxins with altered protease specificity |
| US7601740B2 (en) * | 2003-01-16 | 2009-10-13 | Acadia Pharmaceuticals, Inc. | Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases |
| EP1599213A4 (en) * | 2003-02-24 | 2009-07-15 | Ira Sanders | CELL MEMBRANE TRANSLOCATION OF SNARE R GUL S INHIBITORS, ASSOCIATED COMPOSITIONS AND PATHOLOGY TREATMENT PROCESSES |
| US20040204472A1 (en) * | 2003-03-04 | 2004-10-14 | Pharmacia Corporation | Treatment and prevention of obesity with COX-2 inhibitors alone or in combination with weight-loss agents |
| US20060015151A1 (en) * | 2003-03-14 | 2006-01-19 | Aldrich William N | Method of using endoscopic truncal vagoscopy with gastric bypass, gastric banding and other procedures |
| US20070025991A1 (en) * | 2003-03-19 | 2007-02-01 | Charalabos Pothoulakis | Use of antagonists of ghrelin or ghrelin receptor to treat intestinal inflammation |
| US20050129677A1 (en) * | 2003-12-10 | 2005-06-16 | Shengwen Li | Lipid rafts and clostridial toxins |
| KR101330775B1 (ko) * | 2004-03-03 | 2013-11-18 | 레반스 테라퓨틱스, 아이엔씨. | 보툴리눔 독소의 국소 적용 및 경피 전달을 위한 조성물 및 방법 |
| US7591806B2 (en) * | 2004-05-18 | 2009-09-22 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| CA2518650A1 (en) * | 2004-09-10 | 2006-03-10 | Dimitrios Dimitrakoudis | Clostridium botulinum toxin formulation and method for reducing weight |
| US20060088533A1 (en) * | 2004-10-08 | 2006-04-27 | Charalabos Pothoulakis | Methods of treating inflammatory bowel disease |
| EP1846039A2 (en) * | 2005-01-10 | 2007-10-24 | Research Development Foundation | Targeted chimeric molecules for cancer therapy |
| US7910116B2 (en) * | 2005-08-24 | 2011-03-22 | Allergan, Inc. | Use of a botulinum toxin to improve gastric emptying and/or to treat GERD |
-
2003
- 2003-06-11 US US10/459,767 patent/US20040253274A1/en not_active Abandoned
-
2004
- 2004-06-07 BR BRPI0411316-0A patent/BRPI0411316A/pt not_active IP Right Cessation
- 2004-06-07 EP EP04776328A patent/EP1633393A1/en not_active Withdrawn
- 2004-06-07 JP JP2006533579A patent/JP2007501285A/ja not_active Withdrawn
- 2004-06-07 WO PCT/US2004/017958 patent/WO2005000343A1/en not_active Ceased
- 2004-06-07 CA CA002529010A patent/CA2529010A1/en not_active Abandoned
- 2004-06-07 AU AU2004251708A patent/AU2004251708A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004251708A1 (en) | 2005-01-06 |
| US20040253274A1 (en) | 2004-12-16 |
| WO2005000343A1 (en) | 2005-01-06 |
| CA2529010A1 (en) | 2005-01-06 |
| JP2007501285A (ja) | 2007-01-25 |
| EP1633393A1 (en) | 2006-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0411316A (pt) | uso de uma toxina clostrìdica para reduzir o apetite | |
| BR0308261A (pt) | Métodos extrativos para puruficação de sucralose | |
| SG10201809390QA (en) | Modulators of indoleamine 2,3-dioxygenase and methods of using the same | |
| DE60314633D1 (de) | Substituierte 1,3-diphenylprop-2-en-1-on derivate, deren herstellung und anwendungen | |
| IL154888A0 (en) | Topical composition containing at least one vitamin d or one vitamin d analogue and at least one corticosteroid | |
| BR0316027A (pt) | Formulações de toxina botulina para administração oral | |
| BR0109703A (pt) | Derivados de piperazina | |
| MXPA06000921A (es) | Derivados de benzamidazoles como inhibidores de mek. | |
| CY1111470T1 (el) | Νεες φαρμακευτικες συνθεσεις που περιεχουν φλιβανσερινη πολυμορφη α | |
| MXPA06000407A (es) | Isomero c cci-779. | |
| UY27755A1 (es) | Nuevas composiciones farmacéuticas basadas en anticolinérgicos e inhibidores. | |
| BR0211972A (pt) | Composição oftálmica | |
| ATE370770T1 (de) | Hautreinigungsmittel | |
| MXPA06012961A (es) | Ficotoxinas y usos de las mismas. | |
| MY139228A (en) | Imidazolinylmethyl aralkylsulfonamides | |
| MX2024001889A (es) | Compuestos deuterados. | |
| MXPA06000636A (es) | Formulaciones semi-solidas para la administracion oral de taxoides. | |
| TNSN06012A1 (en) | Emulsifying systems containing azetidine derivatives | |
| PL380665A1 (pl) | Farmaceutyczne kompozycje | |
| BRPI0411820B8 (pt) | composição farmacêutica para administração parenteral, e seus usos | |
| UA81664C2 (ru) | Производные дифенилмочевины и их применение, как блокаторов хлоридных каналов | |
| TWI349545B (en) | Pharmaceutical composition | |
| BRPI0414423A (pt) | inibidores de pace4, suas composições farmacêuticas e respectivos usos | |
| DE602004022578D1 (de) | Antitumorale terpen-verbindungen | |
| DE60309926D1 (de) | Steroid-verbindungen mit anti-tumoraler wirkung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A, 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |