BRPI0411353A - moléculas de corina modificadas tendo seqüências de ativação substitutas e aplicações das mesmas - Google Patents

moléculas de corina modificadas tendo seqüências de ativação substitutas e aplicações das mesmas

Info

Publication number
BRPI0411353A
BRPI0411353A BRPI0411353-5A BRPI0411353A BRPI0411353A BR PI0411353 A BRPI0411353 A BR PI0411353A BR PI0411353 A BRPI0411353 A BR PI0411353A BR PI0411353 A BRPI0411353 A BR PI0411353A
Authority
BR
Brazil
Prior art keywords
molecules
modified
corina
applications
activation sequences
Prior art date
Application number
BRPI0411353-5A
Other languages
English (en)
Inventor
Qingyu Wu
Original Assignee
Schering Aktiengellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengellschaft filed Critical Schering Aktiengellschaft
Publication of BRPI0411353A publication Critical patent/BRPI0411353A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"MOLéCULAS DE CORINA MODIFICADAS TENDO SEQüêNCIAS DE ATIVAçãO SUBSTITUTAS E APLICAçõES DAS MESMAS". Esta invenção se refere a novas moléculas corina modificadas, ou fragmentos ou derivados das mesmas, compreendendo uma seqüência de ativação substituta. As moléculas corina modificadas são clivadas em uma seqüência de ativação substituta, deste modo produzindo moléculas corina ativadas, ou fragmentos ou derivados das mesmas, que apresentam a atividade funcional de moléculas corina selvagens, que ocorrem naturalmente. As moléculas corina modificadas podem ser usadas para tratar uma varidade de doenças ou distúrbios, inclusive falência cardíaca congestiva e enfarte agudo do miocárdio.
BRPI0411353-5A 2003-06-11 2004-06-09 moléculas de corina modificadas tendo seqüências de ativação substitutas e aplicações das mesmas BRPI0411353A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47768303P 2003-06-11 2003-06-11
PCT/US2004/018669 WO2004111225A1 (en) 2003-06-11 2004-06-09 Novel modified corin molecules having substitute activation sequences and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0411353A true BRPI0411353A (pt) 2006-07-11

Family

ID=33551745

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411353-5A BRPI0411353A (pt) 2003-06-11 2004-06-09 moléculas de corina modificadas tendo seqüências de ativação substitutas e aplicações das mesmas

Country Status (15)

Country Link
US (1) US7176013B2 (pt)
EP (1) EP1636356A1 (pt)
JP (1) JP2007502132A (pt)
KR (1) KR20060022683A (pt)
CN (2) CN1836037A (pt)
AU (1) AU2004248192A1 (pt)
BR (1) BRPI0411353A (pt)
CA (1) CA2527361A1 (pt)
IL (1) IL172095A0 (pt)
MX (1) MXPA05013321A (pt)
NO (1) NO20060144L (pt)
PL (1) PL379196A1 (pt)
RU (1) RU2006100035A (pt)
WO (1) WO2004111225A1 (pt)
ZA (1) ZA200600224B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026255A1 (en) * 2002-06-25 2005-02-03 Morser John Michael Corin, a serine protease
TW200723151A (en) * 2005-12-07 2007-06-16 Era Digital Media Co Business website method
US20110160128A1 (en) * 2008-03-28 2011-06-30 Qingyu Wu Corin for Treating Obesity and Diabetes
WO2010096658A1 (en) 2009-02-19 2010-08-26 The Cleveland Clinic Foundation Corin as a marker for heart failure
US10314894B2 (en) * 2014-02-12 2019-06-11 The Cleveland Clinic Foundation Treatment of cardio-renal disease using PCSK6
EP3895529B1 (en) * 2016-02-29 2026-04-29 Regeneron Pharmaceuticals, Inc. Rodents having a humanized tmprss gene
CN105734070A (zh) * 2016-04-11 2016-07-06 苏州大学 Corin基因变异体及其用途
CN108066286B (zh) * 2016-11-10 2021-06-29 复旦大学 炔丙基半胱氨酸纳米粒长循环脂质体及其制备方法和用途
CN118530307B (zh) * 2024-06-14 2025-09-09 中国人民解放军军事科学院军事医学研究院 一种阻断pts途径的多肽及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0292009A1 (en) * 1987-05-22 1988-11-23 Zymogenetics, Inc. Fibrinolytic proteins
US5869637A (en) * 1996-07-22 1999-02-09 Incyte Pharmaceuticals, Inc. Human Kallikrein
US5968782A (en) * 1996-12-04 1999-10-19 Brigham And Womens's Hospital, Inc. Mast cell protease that cleaves fibrinogen
US6479274B1 (en) * 1997-02-13 2002-11-12 Amrad Operations Pty., Ltd. DNA molecules encoding human HELA2 or testisin serine proteinases
ATE294869T1 (de) * 1997-08-22 2005-05-15 Roche Diagnostics Gmbh Autokatalytisch aktivierbare zymogene vorstufen von proteasen und deren verwendung
EP0927764B1 (de) * 1997-12-03 2004-05-26 Boehringer Mannheim Gmbh Chimäre Serinproteasen
ES2307338T3 (es) * 1998-06-05 2008-11-16 Bayer Schering Pharma Aktiengesellschaft Corina, una serina proteasa.
US6420157B1 (en) * 1999-04-30 2002-07-16 Ortho-Mcneil Pharmaceutical, Inc. Zymogen activation system
KR20020073576A (ko) * 2000-02-03 2002-09-27 코르바스 인터내셔날, 인코포레이티드 트랜스막 세린 프로테아제를 암호화하는 핵산 분자,암호화된 단백질 및 이에 기초한 방법
CA2408630A1 (en) * 2000-06-19 2001-12-27 Dyax Corp. Novel enterokinase cleavage sequences
CZ20021571A3 (cs) * 2000-09-04 2002-09-11 Hyo-Joon Kim Mimetické peptidy k epitopu apolipoproteinu B-110, jejich konkatemer a modifikované peptidy, a vakcinační přípravek, který je obsahuje
FR2831170B1 (fr) * 2001-10-19 2004-03-19 Inst Nat Sante Rech Med Proteines c modifiees activables directement par la thrombine
US20040132156A1 (en) * 2002-10-04 2004-07-08 Schering Aktiengesellschaft Modified hepsin molecules having a substitute activation sequence and uses thereof

Also Published As

Publication number Publication date
US7176013B2 (en) 2007-02-13
RU2006100035A (ru) 2006-08-27
CN1836037A (zh) 2006-09-20
US20050003416A1 (en) 2005-01-06
KR20060022683A (ko) 2006-03-10
WO2004111225A8 (en) 2006-04-06
AU2004248192A1 (en) 2004-12-23
IL172095A0 (en) 2009-02-11
CA2527361A1 (en) 2004-12-23
ZA200600224B (en) 2007-04-25
EP1636356A1 (en) 2006-03-22
NO20060144L (no) 2006-01-10
CN101109011A (zh) 2008-01-23
PL379196A1 (pl) 2006-07-24
WO2004111225A1 (en) 2004-12-23
MXPA05013321A (es) 2006-03-09
JP2007502132A (ja) 2007-02-08

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.