BRPI0412253A - nicotinamide derivatives useful as pde4 inhibitors - Google Patents

nicotinamide derivatives useful as pde4 inhibitors

Info

Publication number
BRPI0412253A
BRPI0412253A BRPI0412253-4A BRPI0412253A BRPI0412253A BR PI0412253 A BRPI0412253 A BR PI0412253A BR PI0412253 A BRPI0412253 A BR PI0412253A BR PI0412253 A BRPI0412253 A BR PI0412253A
Authority
BR
Brazil
Prior art keywords
pde4 inhibitors
nicotinamide derivatives
derivatives useful
nicotinamide
derivatives
Prior art date
Application number
BRPI0412253-4A
Other languages
Portuguese (pt)
Inventor
Simon Bailey
Christopher Gordon Barber
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BRPI0412253A publication Critical patent/BRPI0412253A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"DERIVADOS DE NICOTINAMIDA úTEIS COMO INIBIDORES DE PDE4". A presente invenção refere-se a derivados de nicotinamida de fórmula geral (I) em que X, Y, n, Z, L e R têm os significados aqui definidos e a processos para a preparação de intermediários usados na preparação de composições que contêm e ao uso de tais derivados."Useful NICOTINAMIDE DERIVATIVES AS PDE4 INHIBITORS". The present invention relates to nicotinamide derivatives of general formula (I) wherein X, Y, n, Z, L and R have the meanings defined herein and to processes for the preparation of intermediates used in the preparation of compositions containing and the use of such derivatives.

BRPI0412253-4A 2003-07-25 2004-07-13 nicotinamide derivatives useful as pde4 inhibitors BRPI0412253A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0317472.9A GB0317472D0 (en) 2003-07-25 2003-07-25 Nicotinamide derivatives useful as PDE4 inhibitors
PCT/IB2004/002376 WO2005009989A1 (en) 2003-07-25 2004-07-13 Nicotinamide derivatives useful as pde4 inhibitors

Publications (1)

Publication Number Publication Date
BRPI0412253A true BRPI0412253A (en) 2006-09-19

Family

ID=27772706

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412253-4A BRPI0412253A (en) 2003-07-25 2004-07-13 nicotinamide derivatives useful as pde4 inhibitors

Country Status (7)

Country Link
EP (1) EP1651635A1 (en)
JP (1) JP2006528659A (en)
BR (1) BRPI0412253A (en)
CA (1) CA2533663A1 (en)
GB (1) GB0317472D0 (en)
MX (1) MXPA06000989A (en)
WO (1) WO2005009989A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR049384A1 (en) 2004-05-24 2006-07-26 Glaxo Group Ltd PURINA DERIVATIVES
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
US8420647B2 (en) * 2010-01-21 2013-04-16 Hoffmann-La Roche Inc. 4-phenoxy-nicotinamide or 4-phenoxy-pyrimidine-5-carboxamide compounds
US20160214967A1 (en) * 2013-09-30 2016-07-28 The University Of Tokyo Activator of adiponectin receptor
EP4149929B1 (en) * 2020-05-12 2026-01-28 Bayer Aktiengesellschaft Triazine and pyrimidine (thio)amides as fungicidal compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861891A (en) * 1988-08-31 1989-08-29 Pfizer Inc. Antidepressant N-substituted nicotinamide compounds
TW429148B (en) * 1995-10-27 2001-04-11 Pfizer Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases
NZ337698A (en) * 1997-04-04 2001-07-27 Pfizer Prod Inc Nicotinamide derivatives for selective inhibition of phosphodiesterase type 4 (PDE4) and the production of tumour necrosis factor (TNF) useful for the treatment of respiratory, rheumatoid and allergic diseases
GB9715584D0 (en) * 1997-07-23 1997-10-01 Eisai Co Ltd Compounds
DE19854081A1 (en) * 1998-11-24 2000-05-25 Bayer Ag New 2-phenoxy-N-pyrazolyl-nicotinamide derivatives, useful as pre- or post-emergence, total or selective herbicides
KR100698982B1 (en) * 2002-02-11 2007-03-26 화이자 인코포레이티드 Nicotinamide Derivatives Useful as PDE4 Inhibitors

Also Published As

Publication number Publication date
WO2005009989A8 (en) 2006-03-02
GB0317472D0 (en) 2003-08-27
JP2006528659A (en) 2006-12-21
WO2005009989A1 (en) 2005-02-03
CA2533663A1 (en) 2005-02-03
MXPA06000989A (en) 2006-04-27
EP1651635A1 (en) 2006-05-03

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: A61K 31/4427 (2010.01), A61K 31/44 (2010.01), A61K

B15K Others concerning applications: alteration of classification

Ipc: A61K 31/44 (2006.01), A61K 31/4427 (2006.01), A61K