BRPI0412496A - fornecimento de um fármaco ativo para a parte posterior do olho através do fornecimento subconjuntival ou periocular de um pró-fármaco - Google Patents

fornecimento de um fármaco ativo para a parte posterior do olho através do fornecimento subconjuntival ou periocular de um pró-fármaco

Info

Publication number
BRPI0412496A
BRPI0412496A BRPI0412496-0A BRPI0412496A BRPI0412496A BR PI0412496 A BRPI0412496 A BR PI0412496A BR PI0412496 A BRPI0412496 A BR PI0412496A BR PI0412496 A BRPI0412496 A BR PI0412496A
Authority
BR
Brazil
Prior art keywords
active drug
delivery
prodrug
periocular
eye
Prior art date
Application number
BRPI0412496-0A
Other languages
English (en)
Inventor
Patrick M Hughes
Orest Olejnik
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BRPI0412496A publication Critical patent/BRPI0412496A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"FORNECIMENTO DE UM FáRMACO ATIVO PARA A PARTE POSTERIOR DO OLHO ATRAVéS DO FORNECIMENTO SUBCONJUNTIVAL OU PERIOCULAR DE UM PRó-FáRMACO". A presente invenção refere-se a um método de fornecimento sustentado de um fármaco ativo para uma parte posterior de um olho de um mamífero para tratar ou evitar uma doença ou condição afetando o referido mamífero, no qual a referida doença ou condição pode ser tratada ou evitada por ação do respectivo fármaco ativo sobre a referida parte posterior do olho, compreendendo a administração de uma quantidade eficaz de um éster ou pró-fármaco do fármaco ativo subconjuntivamente ou periocularmente. De preferência, o fármaco ativo é mais do que cerca de 10 vezes mais ativo do que o pró-fármaco. Outros aspectos desta invenção lidam com o tratamento de certas doenças pelo fornecimento periocular ou subconjuntival de um éster pró-fármaco, e certos produtos farmacêuticos contendo éster pró-fármaco para administração periocular ou subconjuntival.
BRPI0412496-0A 2003-07-10 2004-07-07 fornecimento de um fármaco ativo para a parte posterior do olho através do fornecimento subconjuntival ou periocular de um pró-fármaco BRPI0412496A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/617,468 US20050009910A1 (en) 2003-07-10 2003-07-10 Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug
PCT/US2004/021938 WO2005011741A2 (en) 2003-07-10 2004-07-07 Delivery of a drug via subconjuctival or periocular delivery of a prodrug in a polymeric microparticle

Publications (1)

Publication Number Publication Date
BRPI0412496A true BRPI0412496A (pt) 2006-09-19

Family

ID=33564972

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412496-0A BRPI0412496A (pt) 2003-07-10 2004-07-07 fornecimento de um fármaco ativo para a parte posterior do olho através do fornecimento subconjuntival ou periocular de um pró-fármaco

Country Status (16)

Country Link
US (2) US20050009910A1 (pt)
EP (1) EP1644047A2 (pt)
JP (1) JP2007528851A (pt)
KR (1) KR20060033008A (pt)
CN (1) CN1882362A (pt)
AU (1) AU2004260645B2 (pt)
BR (1) BRPI0412496A (pt)
CA (1) CA2531753A1 (pt)
IL (1) IL172583A (pt)
MX (1) MXPA06000408A (pt)
NO (1) NO20056174L (pt)
NZ (2) NZ544027A (pt)
PL (1) PL380169A1 (pt)
RU (1) RU2353393C2 (pt)
WO (1) WO2005011741A2 (pt)
ZA (1) ZA200510129B (pt)

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Also Published As

Publication number Publication date
ZA200510129B (en) 2007-02-28
IL172583A (en) 2011-02-28
EP1644047A2 (en) 2006-04-12
WO2005011741A2 (en) 2005-02-10
US20120157499A1 (en) 2012-06-21
US20050009910A1 (en) 2005-01-13
MXPA06000408A (es) 2006-03-17
IL172583A0 (en) 2006-04-10
NO20056174L (no) 2006-01-25
KR20060033008A (ko) 2006-04-18
AU2004260645B2 (en) 2010-03-11
RU2006104983A (ru) 2006-06-27
PL380169A1 (pl) 2007-01-08
RU2353393C2 (ru) 2009-04-27
WO2005011741A3 (en) 2005-04-14
JP2007528851A (ja) 2007-10-18
CN1882362A (zh) 2006-12-20
CA2531753A1 (en) 2005-02-10
AU2004260645A1 (en) 2005-02-10
NZ544027A (en) 2010-07-30
NZ582376A (en) 2012-02-24

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