BRPI0412898A - unsubstituted indolyl-3-glyoxylic acid amides, their use as a medicament, and process for their production - Google Patents

unsubstituted indolyl-3-glyoxylic acid amides, their use as a medicament, and process for their production

Info

Publication number
BRPI0412898A
BRPI0412898A BRPI0412898-2A BRPI0412898A BRPI0412898A BR PI0412898 A BRPI0412898 A BR PI0412898A BR PI0412898 A BRPI0412898 A BR PI0412898A BR PI0412898 A BRPI0412898 A BR PI0412898A
Authority
BR
Brazil
Prior art keywords
production
medicament
acid amides
glyoxylic acid
unsubstituted indolyl
Prior art date
Application number
BRPI0412898-2A
Other languages
Portuguese (pt)
Inventor
Matthias Gerlach
Tilmann Schuster
Peter Schmidt
Silke Baasner
Eckhard Guenther
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of BRPI0412898A publication Critical patent/BRPI0412898A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"AMIDAS DE áCIDO INDOLIL-3-GLIOXìLICO N-SUBSTITUìDAS, SEU USO COMO UM MEDICAMENTO, E PROCESSO PARA SUA PRODUçãO". A invenção refere-se a novas amidas de ácido indolil-3-glioxílico N-substituídas de fórmula geral (I), sua produção, e seu uso como um medicamento, especialmente para o tratamento de tumores."N-REPLACED INDOLYL-3-GLIOXYLIC ACID AMIDS, ITS USE AS A MEDICINAL PRODUCT, AND PROCESS FOR THEIR PRODUCTION". The invention relates to novel N-substituted indolyl-3-glyoxylic acid amides of formula (I), their production, and their use as a medicament, especially for the treatment of tumors.

BRPI0412898-2A 2003-07-25 2004-07-09 unsubstituted indolyl-3-glyoxylic acid amides, their use as a medicament, and process for their production BRPI0412898A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10334040A DE10334040A1 (en) 2003-07-25 2003-07-25 Novel N-substituted indolyl-3-glyoxylic acid amides, their use as medicaments and process for their preparation
PCT/EP2004/007573 WO2005014542A2 (en) 2003-07-25 2004-07-09 Novel n-substituted indolyl-3-glyoxylic acid amides, use thereof as a medicament against cancer, and method for the production thereof

Publications (1)

Publication Number Publication Date
BRPI0412898A true BRPI0412898A (en) 2006-10-03

Family

ID=34129467

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412898-2A BRPI0412898A (en) 2003-07-25 2004-07-09 unsubstituted indolyl-3-glyoxylic acid amides, their use as a medicament, and process for their production

Country Status (18)

Country Link
EP (1) EP1651600A2 (en)
JP (1) JP2007503376A (en)
KR (1) KR20060037398A (en)
CN (1) CN1839129A (en)
AR (1) AR045928A1 (en)
AU (1) AU2004263238A1 (en)
BR (1) BRPI0412898A (en)
CA (1) CA2533433A1 (en)
DE (1) DE10334040A1 (en)
IL (1) IL173335A0 (en)
MX (1) MXPA06000995A (en)
NO (1) NO20060697L (en)
RS (1) RS20060049A (en)
RU (1) RU2317293C9 (en)
TW (1) TW200524863A (en)
UA (1) UA83498C2 (en)
WO (1) WO2005014542A2 (en)
ZA (1) ZA200601300B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2049520A4 (en) 2006-08-07 2011-01-05 Ironwood Pharmaceuticals Inc Indole compounds
AR084433A1 (en) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc FAAH INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19636150A1 (en) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituted indole-3-glyoxylamides with antiasthmatic, antiallergic and immunosuppressive / immunomodulating effects
AU2002324591A1 (en) * 2001-08-01 2003-02-17 The Ohio State University Clinical refractive instruments
AU2002323474B2 (en) * 2001-09-13 2006-10-05 Synta Pharmaceuticals Corp 3-glyoxlylamideindoles for treating cancer

Also Published As

Publication number Publication date
AU2004263238A1 (en) 2005-02-17
RS20060049A (en) 2008-08-07
CA2533433A1 (en) 2005-02-17
DE10334040A1 (en) 2005-03-10
MXPA06000995A (en) 2006-04-11
JP2007503376A (en) 2007-02-22
CN1839129A (en) 2006-09-27
RU2317293C2 (en) 2008-02-20
NO20060697L (en) 2006-02-14
WO2005014542A2 (en) 2005-02-17
IL173335A0 (en) 2006-06-11
TW200524863A (en) 2005-08-01
WO2005014542A3 (en) 2006-10-19
RU2317293C9 (en) 2008-05-10
ZA200601300B (en) 2007-03-28
AR045928A1 (en) 2005-11-16
EP1651600A2 (en) 2006-05-03
RU2006105708A (en) 2006-06-27
KR20060037398A (en) 2006-05-03
UA83498C2 (en) 2008-07-25

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. C07D 209/00; A61P 35/00

Ipc: C07D 209/00 (2011.01), A61P 35/00 (2011.01)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.