BRPI0413132A - composições e compostos bicìclicos como inibidores de pdf - Google Patents

composições e compostos bicìclicos como inibidores de pdf

Info

Publication number
BRPI0413132A
BRPI0413132A BRPI0413132-0A BRPI0413132A BRPI0413132A BR PI0413132 A BRPI0413132 A BR PI0413132A BR PI0413132 A BRPI0413132 A BR PI0413132A BR PI0413132 A BRPI0413132 A BR PI0413132A
Authority
BR
Brazil
Prior art keywords
compositions
compounds
bicyclic compounds
pdf inhibitors
inhibitors
Prior art date
Application number
BRPI0413132-0A
Other languages
English (en)
Inventor
Valentina Molteni
Xiaohui He
Andreas Kreusch
Juliet Nabakka
Kunyong Yang
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of BRPI0413132A publication Critical patent/BRPI0413132A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSIçõES E COMPOSTOS BICìCLICOS COMO INIBIDORES DE PDF". A presente invenção refere-se a novos compostos bicíclicos, aos usos destes compostos em várias aplicações medicinais, incluindo tratar distúrbios receptivos a tratamento por inibidores de peptidil desformilase tais como tratamento de infecções bacterianas, e às composições farmacêuticas compreendendo estes compostos.
BRPI0413132-0A 2003-07-31 2004-07-30 composições e compostos bicìclicos como inibidores de pdf BRPI0413132A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49176503P 2003-07-31 2003-07-31
PCT/US2004/024938 WO2005011611A2 (en) 2003-07-31 2004-07-30 Bicyclic compounds and compositions as pdf inhibitors

Publications (1)

Publication Number Publication Date
BRPI0413132A true BRPI0413132A (pt) 2006-10-03

Family

ID=34115548

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413132-0A BRPI0413132A (pt) 2003-07-31 2004-07-30 composições e compostos bicìclicos como inibidores de pdf

Country Status (9)

Country Link
US (2) US7253164B2 (pt)
EP (1) EP1651643A4 (pt)
JP (1) JP2007500728A (pt)
CN (1) CN100471856C (pt)
AU (1) AU2004261283B2 (pt)
BR (1) BRPI0413132A (pt)
CA (1) CA2533824A1 (pt)
MX (1) MXPA06001081A (pt)
WO (1) WO2005011611A2 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002217999A1 (en) 2000-11-01 2002-05-15 Cor Therapeutics, Inc. Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides
US20070197512A1 (en) * 2006-01-27 2007-08-23 Japan Tobacco Inc. Carboxylic Acid Compounds and Use Thereof
WO2007086504A1 (ja) * 2006-01-27 2007-08-02 Japan Tobacco Inc. カルボン酸化合物及びその用途
JP2016147807A (ja) * 2013-06-04 2016-08-18 日本理化学工業株式会社 ヒドロキサム酸誘導体またはその塩
CN103550217B (zh) * 2013-10-31 2014-12-17 四川大学 一种靶向于细菌rna聚合酶的抗结核小分子化合物
JO3719B1 (ar) 2014-11-20 2021-01-31 Takeda Pharmaceuticals Co 4- أوكسو-4،3- داي هيدرو-3،2،1- بنزوترايازينات كمواد ضابطة لأجل gpr139
PL4031552T3 (pl) 2019-09-16 2025-03-17 Takeda Pharmaceutical Company Limited Pochodne azolowo-skondensowanych pirydazyn-3(2h)-onów
JP7697974B2 (ja) 2020-05-08 2025-06-24 武田薬品工業株式会社 Ｇｐｒ１３９アゴニストの置換ベンゾトリアジノン代謝物

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2863864A (en) * 1958-12-09 Chchjconh-
US2851457A (en) * 1956-04-09 1958-09-09 Searle & Co Amidinoalkylbenzothiazinones and processes
US2824102A (en) * 1956-09-13 1958-02-18 Searle & Co Aminoalkyl-2h, 1, 4-benzothiazin-3(4h)-ones
FR1438225A (fr) * 1964-09-24 1966-05-13 Centre Nat Rech Scient Dérivés de la benzothiazine et leur préparation
FR1469476A (fr) * 1965-08-11 1967-02-17 Centre Nat Rech Scient Dérivés de benzothiazine et de benzothiazépine et leur préparation
JPS54109985A (en) * 1978-02-10 1979-08-29 Sumitomo Chem Co Ltd 1,4-benzoazine derivative and bactericidal agent containing the same it component for agriculture and floriculture
US4721784A (en) * 1986-12-22 1988-01-26 Ortho Pharmaceutical Corporation 6-benzoxazinyl-2,3,4,5-tetrahydropyridazin-3-ones
DE3823576A1 (de) * 1988-07-12 1990-01-18 Boehringer Ingelheim Kg Substituierte 3-amino-3,4-dihydrocarbostyrile, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
ES2067744T3 (es) * 1989-06-09 1995-04-01 Upjohn Co Aminas heterociclicas con actividad sobre el sistema nervioso central.
JP3358069B2 (ja) * 1991-12-24 2002-12-16 武田薬品工業株式会社 三環性複素環類、その製造法及び剤
CA2166700C (en) * 1993-07-27 2000-04-18 Arthur G. Romero Heterocyclic amines having central nervous system activity
BR9506864A (pt) * 1994-02-04 1997-09-09 Smithkline Beecham Plc Processo para epoxidar olefinas proquirais e um catalisador para as mesmas e intermdiários para produzir o catalisador
GB9713726D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
WO1999007731A1 (en) * 1997-08-11 1999-02-18 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
US6207687B1 (en) * 1998-07-31 2001-03-27 Merck & Co., Inc. Substituted imidazoles having cytokine inhibitory activity
AU4249700A (en) 1999-04-19 2000-11-02 Sumitomo Pharmaceuticals Company, Limited Hydroxamic acid derivative
JP2003514022A (ja) * 1999-11-18 2003-04-15 アンテックスファーマ・インコーポレーテッド 置換された１−ベンズアゼピンとその誘導体
US20030105124A1 (en) * 2000-04-27 2003-06-05 Susan Beth Sobolov-Jaynes Substituted benzolactam compounds
JP2002128769A (ja) 2000-10-17 2002-05-09 Sumitomo Pharmaceut Co Ltd ベンゾチアジン−３−オン誘導体
GB0031088D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
ES2275621T3 (es) * 2000-12-21 2007-06-16 Glaxo Group Limited Antibioticos macrolidos.
JP2002332279A (ja) * 2001-05-10 2002-11-22 Senju Pharmaceut Co Ltd ベンゾチアゾリルヒドロキサム酸誘導体およびその用途
EP1392317A4 (en) * 2001-05-16 2005-10-19 Antexpharma Inc SUBSTITUTED 1-BENZAZEPINE AND DERIVATIVES THEREOF
US7504537B2 (en) 2001-12-27 2009-03-17 Dainippon Sumitomo Pharma Co., Ltd. Hydroxamic acid derivative and MMP inhibitor containing the same as active ingredient

Also Published As

Publication number Publication date
US20070259852A1 (en) 2007-11-08
WO2005011611A3 (en) 2005-11-03
WO2005011611A2 (en) 2005-02-10
CN100471856C (zh) 2009-03-25
JP2007500728A (ja) 2007-01-18
CN1860116A (zh) 2006-11-08
AU2004261283B2 (en) 2008-05-01
AU2004261283A1 (en) 2005-02-10
EP1651643A2 (en) 2006-05-03
MXPA06001081A (es) 2006-04-24
US7579363B2 (en) 2009-08-25
US7253164B2 (en) 2007-08-07
US20050197326A1 (en) 2005-09-08
EP1651643A4 (en) 2008-10-08
CA2533824A1 (en) 2005-02-10

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. C07D 417/00, 401/00, 279/00, 211/00; A61K 31/4985, 31/5415, 31/438; A61P 31/04

Ipc: C07D 417/00 (2011.01), C07D 401/00 (2011.01), C07D

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: CONFORME ARTIGO 10O DA RESOLUCAO 124/06, CABE SER ARQUIVADO REFERENTE AO NAO RECOLHIMENTO DA 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2138 DE 27/12/2011.