BRPI0413679A - formulações de um inibidor seletivo da ciclooxigenase-2 e de um agente de modulação da serotonina para o tratamento da neoplasia - Google Patents
formulações de um inibidor seletivo da ciclooxigenase-2 e de um agente de modulação da serotonina para o tratamento da neoplasiaInfo
- Publication number
- BRPI0413679A BRPI0413679A BRPI0413679-9A BRPI0413679A BRPI0413679A BR PI0413679 A BRPI0413679 A BR PI0413679A BR PI0413679 A BRPI0413679 A BR PI0413679A BR PI0413679 A BRPI0413679 A BR PI0413679A
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitor
- treatment
- formulations
- neoplasia
- modulating agent
- Prior art date
Links
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title abstract 6
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 239000003795 chemical substances by application Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000009826 neoplastic cell growth Effects 0.000 title abstract 3
- 229940076279 serotonin Drugs 0.000 title abstract 3
- 229940093444 Cyclooxygenase 2 inhibitor Drugs 0.000 title abstract 2
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title abstract 2
- 208000035269 cancer or benign tumor Diseases 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"FORMULAçõES DE UM INIBIDOR SELETIVO DA CICLOOXIGENASE-2 E DE UM AGENTE DE MODULAçãO DA SEROTONINA PARA O TRATAMENTO DA NEOPLASIA". A presente invenção proporciona formulações e métodos para o tratamento de neoplasia em um indivíduo. Mais particularmente, a invenção proporciona uma terapêutica de associação para o tratamento de uma neoplasia compreendendo a administração a um indivíduo de um agente de modulação da serotonina associado a um inibidor seletivo da ciclooxigenase-2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49720203P | 2003-08-22 | 2003-08-22 | |
| PCT/US2004/027326 WO2005018569A2 (en) | 2003-08-22 | 2004-08-20 | Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin modulating agent for the treatment of neoplasia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0413679A true BRPI0413679A (pt) | 2006-10-24 |
Family
ID=34216096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0413679-9A BRPI0413679A (pt) | 2003-08-22 | 2004-08-20 | formulações de um inibidor seletivo da ciclooxigenase-2 e de um agente de modulação da serotonina para o tratamento da neoplasia |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050085477A1 (pt) |
| EP (1) | EP1660079A2 (pt) |
| JP (1) | JP2007503396A (pt) |
| BR (1) | BRPI0413679A (pt) |
| CA (1) | CA2536340A1 (pt) |
| MX (1) | MXPA06002112A (pt) |
| WO (1) | WO2005018569A2 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7153286B2 (en) | 2002-05-24 | 2006-12-26 | Baxter International Inc. | Automated dialysis system |
| US7175606B2 (en) | 2002-05-24 | 2007-02-13 | Baxter International Inc. | Disposable medical fluid unit having rigid frame |
| FR2888506A1 (fr) * | 2005-07-12 | 2007-01-19 | Cerenis Sa | Utilisation de la 4-(3,4-dichloro-phenyl)-1,2,3,4- tetrahydro-naphtalen-1-ylamine pour le traitement du cancer |
| FR2909283A1 (fr) * | 2006-11-30 | 2008-06-06 | Cerep Sa | Produit de combinaison contenant de la n-desmethylsertraline, ou un de ses sels, et un agent antineoplasique pour le traitement du cancer |
| AU2008299921B2 (en) | 2007-09-13 | 2012-03-01 | Concert Pharmaceuticals, Inc. | Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof |
| CA2666036C (en) * | 2008-05-16 | 2017-09-12 | Chien-Hung Chen | Novel compositions and methods for treating hyperproliferative diseases |
| EP2771341A4 (en) * | 2011-10-28 | 2015-09-23 | Univ Texas | NEW COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5189179A (en) * | 1990-08-29 | 1993-02-23 | Merrell Dow Pharmaceuticals Inc. | Serotonin 5ht1a agonists |
| US5618846A (en) * | 1990-12-17 | 1997-04-08 | University Of Manitoba | Treatment method for cancer |
| US5436246A (en) * | 1992-09-17 | 1995-07-25 | Merrell Dow Pharmaceuticals Inc. | Serotonin receptor agents |
| US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| US5633272A (en) * | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
| DK1288206T3 (da) * | 1996-04-12 | 2008-11-24 | Searle Llc | Substituerede benzensulfonamidderivater som prolægemidler af COX-2-inhibitorer |
| US6034256A (en) * | 1997-04-21 | 2000-03-07 | G.D. Searle & Co. | Substituted benzopyran derivatives for the treatment of inflammation |
| US6077850A (en) * | 1997-04-21 | 2000-06-20 | G.D. Searle & Co. | Substituted benzopyran analogs for the treatment of inflammation |
| US5972986A (en) * | 1997-10-14 | 1999-10-26 | G.D. Searle & Co. | Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia |
| US20040147581A1 (en) * | 2002-11-18 | 2004-07-29 | Pharmacia Corporation | Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy |
-
2004
- 2004-08-20 CA CA002536340A patent/CA2536340A1/en not_active Abandoned
- 2004-08-20 BR BRPI0413679-9A patent/BRPI0413679A/pt not_active Application Discontinuation
- 2004-08-20 EP EP04786557A patent/EP1660079A2/en not_active Withdrawn
- 2004-08-20 US US10/922,511 patent/US20050085477A1/en not_active Abandoned
- 2004-08-20 WO PCT/US2004/027326 patent/WO2005018569A2/en not_active Ceased
- 2004-08-20 MX MXPA06002112A patent/MXPA06002112A/es not_active Application Discontinuation
- 2004-08-20 JP JP2006524108A patent/JP2007503396A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06002112A (es) | 2006-05-17 |
| WO2005018569A3 (en) | 2005-11-03 |
| WO2005018569A2 (en) | 2005-03-03 |
| EP1660079A2 (en) | 2006-05-31 |
| JP2007503396A (ja) | 2007-02-22 |
| CA2536340A1 (en) | 2005-03-03 |
| US20050085477A1 (en) | 2005-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |