BRPI0413968A - composto de anel condensado e seu uso - Google Patents

composto de anel condensado e seu uso

Info

Publication number
BRPI0413968A
BRPI0413968A BRPI0413968-2A BRPI0413968A BRPI0413968A BR PI0413968 A BRPI0413968 A BR PI0413968A BR PI0413968 A BRPI0413968 A BR PI0413968A BR PI0413968 A BRPI0413968 A BR PI0413968A
Authority
BR
Brazil
Prior art keywords
sinusitis
compound
condensed ring
ring compound
pneumonia
Prior art date
Application number
BRPI0413968-2A
Other languages
English (en)
Inventor
Takeuchi Jun
Itadani Satohi
Itadani Satoshi
Nakayama Yoshisuke
Tatsumi Tadashi
Fujita Manabu
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of BRPI0413968A publication Critical patent/BRPI0413968A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C205/60—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms in ortho-position to the carboxyl group, e.g. nitro-salicylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSTO DE ANEL CONDENSADO E SEU USO". A presente invenção refere-se a um composto de fórmula (I): (onde todos os símbolos têm os mesmos significados conforme descritos anteriormente). O composto antagoniza cysLT~ 2~ e, por esta razão, é útil como um agente para a prevenção e/ou tratamento de doenças respiratórias tais como asma brónquica, doença pulmonar obstrutiva crónica, enfisema pulmonar, bronquite crónica, pneumonia (por exemplo, pneumonia intersticial, etc.), síndrome respiratória aguda grave (SARS), síndrome da angústia respiratória aguda (ARDS), rinite alérgica, sinusite (por exemplo, sinusite aguda, sinusite crónica, etc.), e semelhantes, ou como expectorante ou antitússico.
BRPI0413968-2A 2003-09-01 2004-08-31 composto de anel condensado e seu uso BRPI0413968A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003309232 2003-09-01
JP2003369547 2003-10-29
PCT/JP2004/012563 WO2005021518A1 (ja) 2003-09-01 2004-08-31 縮環化合物およびその用途

Publications (1)

Publication Number Publication Date
BRPI0413968A true BRPI0413968A (pt) 2006-10-31

Family

ID=34277677

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413968-2A BRPI0413968A (pt) 2003-09-01 2004-08-31 composto de anel condensado e seu uso

Country Status (14)

Country Link
US (2) US7763610B2 (pt)
EP (2) EP1661892B1 (pt)
JP (1) JP4720502B2 (pt)
KR (1) KR101135911B1 (pt)
AU (1) AU2004268865B8 (pt)
BR (1) BRPI0413968A (pt)
CA (1) CA2537355C (pt)
ES (1) ES2425746T3 (pt)
IL (1) IL173898A (pt)
MX (1) MXPA06002152A (pt)
NO (1) NO20061513L (pt)
NZ (1) NZ545666A (pt)
RU (1) RU2371436C2 (pt)
WO (1) WO2005021518A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ560513A (en) 2005-02-25 2010-07-30 Ono Pharmaceutical Co Indole compound and use thereof
TWI406664B (zh) * 2006-03-30 2013-09-01 Univ Kyoto 硫氧還蛋白（ｔｈｉｏｒｅｄｏｘｉｎ）產生促進劑
TWI469965B (zh) * 2008-12-22 2015-01-21 Ono Pharmaceutical Co 乙炔基吲哚化合物
MY162757A (en) * 2010-06-21 2017-07-14 Ono Pharmaceutical Co New Crystalline Forms of 4,4’-[4-Fluoro-7-({4-[4-(3-Fluoro-2-Methylphenyl) Butoxy] Phenyl}Ethynyl)-2-Methyl-1H-Indole-1, 3-Diyl] Dibutanoic Acid
WO2013066838A1 (en) * 2011-10-31 2013-05-10 Glaxosmithkline Llc Compounds and methods
US9603907B2 (en) 2012-02-01 2017-03-28 Protalix Ltd. Dry powder formulations of dNase I
WO2016057693A1 (en) 2014-10-10 2016-04-14 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhalation delivery of conjugated oligonucleotide

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE555319A (pt) 1956-03-21 1900-01-01
US3095355A (en) 1961-10-12 1963-06-25 Revlon Aerosol composition
US4618361A (en) * 1983-12-12 1986-10-21 Ciba-Geigy Corporation Acylamides and compositions for the protection of cultivated plants against the phytotoxic action of herbicides
CA1261835A (en) * 1984-08-20 1989-09-26 Masaaki Toda (fused) benz(thio)amides
CA2019335C (en) 1989-06-27 2000-08-01 Mitoshi Konno Phenylalkan (en)oic acids
GB8916774D0 (en) * 1989-07-21 1989-09-06 Bayer Ag New indole derivatives,a process for their preparation and their use in medicaments
US5468898A (en) * 1990-09-10 1995-11-21 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted naphthylene compounds exhibiting selective leukotriene B4 antagonist activity
US5696117A (en) * 1995-11-07 1997-12-09 Ortho Pharmaceutical Corporation Benzoxazine antimicrobial agents
GB9523946D0 (en) 1995-11-23 1996-01-24 Bayer Ag Leukotriene antagonistic benzoic acid derivatives
FR2766824B1 (fr) 1997-07-30 1999-09-10 Adir Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN101284773A (zh) * 2001-08-09 2008-10-15 小野药品工业株式会社 羧酸衍生物及以它为活性成分的药剂
US20040072802A1 (en) * 2002-10-09 2004-04-15 Jingwu Duan Beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha
DE10257785A1 (de) 2002-12-11 2004-07-01 Bayer Healthcare Ag Isophthalsäurederivate

Also Published As

Publication number Publication date
US8318952B2 (en) 2012-11-27
US7763610B2 (en) 2010-07-27
EP1661892A4 (en) 2009-02-18
IL173898A0 (en) 2006-07-05
JPWO2005021518A1 (ja) 2007-11-01
AU2004268865B8 (en) 2011-01-06
MXPA06002152A (es) 2006-05-22
WO2005021518A1 (ja) 2005-03-10
AU2004268865A1 (en) 2005-03-10
CA2537355A1 (en) 2005-03-10
EP2481732A1 (en) 2012-08-01
ES2425746T3 (es) 2013-10-17
RU2371436C2 (ru) 2009-10-27
AU2004268865B2 (en) 2010-12-16
KR20060119903A (ko) 2006-11-24
US20060194797A1 (en) 2006-08-31
CA2537355C (en) 2012-10-09
EP1661892B1 (en) 2013-07-24
JP4720502B2 (ja) 2011-07-13
RU2006110513A (ru) 2007-10-10
NO20061513L (no) 2006-06-01
KR101135911B1 (ko) 2012-04-16
EP1661892A1 (en) 2006-05-31
IL173898A (en) 2012-03-29
US20100234368A1 (en) 2010-09-16
NZ545666A (en) 2009-11-27

Similar Documents

Publication Publication Date Title
BRPI0606870A2 (pt) composto de indol e uso do mesmo
BR0107934A (pt) Carboxamidas de pirimidina úteis como inibidores de isozimas pde4
CR7043A (es) Derivados de eteres utiles como ganetes inhibidores de las isozimas pde4
BRPI0414886A (pt) composições de oligonucleotìdeo e métodos para o tratamento de doença incluindo condições inflamatórias
BR0009446A (pt) Composto, processo para preparar o mesmo, composição uso de um composto, e, métodos para o tratamento ou a prevenção de uma doença em um mamìfero, para o tratamento ou a prevenção de asma em um mamìfero e para o tratamento ou a prevenção de doença pulmonar obstrutiva crÈnica em um mamìfero
BRPI0507041A (pt) composto derivados de sulfonamida para o tratamento de doenças seus usos, processo para a preparação dos compostos e combinação de compostos
BRPI0610321B8 (pt) imidazoquinolinas como inibidores de lipídeo cinase, seu uso e seu processo de preparação, e preparação farmacêutica
ECSP088335A (es) Compuestos de pirimidina amida como inhibidores de pgds
CL2003002746A1 (es) Compuesto derivado de piridazin-3(2h)-ona sustituida en las posiciones 4,5,6; procedimiento de preparacion de dicho compuesto; compuesto intermediario; composicion farmaceutica; y el uso del compuesto para el tratamiento del asma, enfermedad pulmonar
NO20083501L (no) Azaindoler som er anvendelige som inhibitorer for Janus-kinaser
NO20091183L (no) Derivater av 4-(N-azacykloalkyl)-anilider, fremgangsmåte for fremstilling av slike forbindelser, preparater omfattende slike forbindelser samt anvendelse av slike forbindelser for forhindring eller behandling av sykdom
NO20005889D0 (no) Benzimidazolanaloger som ned-regulatorer av IgE
BRPI0507877A (pt) derivados de formamida, composição farmacêutica, uso dos mesmos e combinação
UY28958A1 (es) Nuevos derivados de piridazin-3(2h)-ona
NO20076093L (no) Substituerte amidderivater som proteinkinaseinhibitorer
NO20073722L (no) Farmasoystiske sammensetniger omfattende bendamustin
BRPI0408369A (pt) derivados de indol úteis para o tratamento de doenças
NO20061254L (no) Farmasoytiske blandinger
BR0211450A (pt) Método terapêutico
CL2011001977A1 (es) Compuestos derivados de triazolopiridina, inhibidores de proteinas cinasas activadas por mitogeno p38; composicion farmaceutica; y su uso para el tratamiento de neumonia eosinofilica cronica, asma, enfermedad pulmonar obstructiva cronica y sindrome de angustia respiratoria en adultos, entre otras enfermedades.
BRPI0413968A (pt) composto de anel condensado e seu uso
CL2008003495A1 (es) Compuestos derivados de pirazol; composicion farmaceutica, metodo de preparacion y; su uso para tratar una enfermedad mediada por 5-lo tal como asma, broncocontriccion, enfisema, enfermedades obstructivas o inflamatorias de las vias respiratorias, bronquitis, lesion pulmonar aguda, bronquiectasia, rinitis alergica, entre otras.
DE60225141D1 (de) Verfahren zur erhöhung der in vivo wirksamkeit vonugetieren
MX2009013926A (es) Compuestos de etinilindol.
BRPI0508177A (pt) composto, processo para a produção do composto, composição farmacêutica, uso do composto método para o tratamento de uma doença e produto de combinação

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE AO DESPACHO NA RPI 2269 NA 01/07/2014.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]