BRPI0413976A - análogos da prostaglandina ciclohexila como agonistas do receptor ep4 - Google Patents

análogos da prostaglandina ciclohexila como agonistas do receptor ep4

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Publication number
BRPI0413976A
BRPI0413976A BRPI0413976-3A BRPI0413976A BRPI0413976A BR PI0413976 A BRPI0413976 A BR PI0413976A BR PI0413976 A BRPI0413976 A BR PI0413976A BR PI0413976 A BRPI0413976 A BR PI0413976A
Authority
BR
Brazil
Prior art keywords
cyclohexyl
receptor agonists
prostaglandin analogues
prostaglandin
agonists
Prior art date
Application number
BRPI0413976-3A
Other languages
English (en)
Inventor
David W Old
Robert M Burk
Danny T Dinh
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BRPI0413976A publication Critical patent/BRPI0413976A/pt

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    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
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  • Neurology (AREA)
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Abstract

"ANáLOGOS DA PROSTAGLANDINA CICLOHEXILA COMO AGONISTAS DO RECEPTOR EP~ 4~". A invenção refere-se ao uso de novos análogos ciclohexila das prostaglandinas do tipo E como agonistas EP~ 4~, em geral, e, em particular, como hipotensivos oculares. Os análogos ciclohexila usados de acordo com a invenção são representados pela seguinte fórmula I, em que os segmentos ondulados representam ligação <244> ou <225>, linha tracejada representa a presença ou ausência de uma ligação W, Y, Z, R¬ 1¬, R¬ 2¬ e R¬ 3¬ são como definidos na especificação.
BRPI0413976-3A 2003-08-28 2004-08-16 análogos da prostaglandina ciclohexila como agonistas do receptor ep4 BRPI0413976A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/652,634 US7015243B2 (en) 2003-08-28 2003-08-28 Cyclohexyl prostaglandin analogs as EP4-receptor agonists
PCT/US2004/026607 WO2005023267A1 (en) 2003-08-28 2004-08-16 Cyclohexyl prostaglandin analogs as ep4-receptor agonists

Publications (1)

Publication Number Publication Date
BRPI0413976A true BRPI0413976A (pt) 2006-10-31

Family

ID=34217695

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413976-3A BRPI0413976A (pt) 2003-08-28 2004-08-16 análogos da prostaglandina ciclohexila como agonistas do receptor ep4

Country Status (7)

Country Link
US (3) US7015243B2 (pt)
EP (1) EP1660096A1 (pt)
JP (1) JP2007504134A (pt)
AU (1) AU2004270155A1 (pt)
BR (1) BRPI0413976A (pt)
CA (1) CA2537252A1 (pt)
WO (1) WO2005023267A1 (pt)

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CN101686985A (zh) 2007-05-08 2010-03-31 国立大学法人浜松医科大学 含有ep4激动剂的细胞毒性t细胞的活化剂
US7820661B2 (en) * 2008-04-24 2010-10-26 Allergan, Inc. Substituted gamma lactams as therapeutics agents
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CA2777479C (en) * 2009-04-28 2017-10-17 Ptc Therapeutics, Inc. Treatment of leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones
EA201101576A1 (ru) * 2009-04-28 2012-04-30 Эдисон Фармасьютикалз, Инк. Лекарственная форма токотриенол хинонов для лечения офтальмических (глазных) заболеваний
US20120190637A1 (en) 2009-10-14 2012-07-26 Gemmus Pharma, Inc. Combination therapy treatment for viral infections
CN103167875A (zh) * 2010-08-17 2013-06-19 阿勒根公司 用于治疗角膜浑浊的ep2或ep4激动剂
CA2920856C (en) 2013-08-09 2026-03-03 Ardelyx, Inc. Ph modulating compounds for inhibiting gastrointestinal phosphate uptake
EP3389646A1 (en) 2015-12-17 2018-10-24 BioElectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
EP4091672A4 (en) * 2020-02-18 2024-03-20 National University Corporation Hokkaido University STABLE BIOISOSTER OF RESOLVIN E2

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US7429615B2 (en) 2008-09-30
US7015243B2 (en) 2006-03-21
EP1660096A1 (en) 2006-05-31
AU2004270155A1 (en) 2005-03-17
US7473704B2 (en) 2009-01-06
US20050049227A1 (en) 2005-03-03
CA2537252A1 (en) 2005-03-17
US20060247215A1 (en) 2006-11-02

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